Combined modality radioprotection: enhancement of survival and hematopoietic recovery in gamma-irradiated mice by the joint use of liposomal muramyl tripeptide phosphatidylethanolamine (mtp-pe) and indomethacin

Fedoročko, Peter; Macková, N

doi:10.1016/0192-0561(96)00023-9

Cited by 14 publications

(7 citation statements)

References 32 publications

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“…The combination with additional treatment strategies, namely administration of meloxicam and G-CSF or IB-MECA, an adenosine A 3 receptor agonist, increased the effect on hematopoiesis and survival rate in comparison to the treatment with each single drug [ 121 ]. A similar effect was observed for other NSAIDs as well; e.g., for indomethacin in combination with muramyl tripeptidephosphatidyl ethanolamine [ 122 ] or broncho-vaxom [ 123 ]. Meloxicam was investigated also in a glioblastoma multiforme tumor model because rapid recurrence of this malignancy after resection of the primary tumor has been related to the radiation induced stimulation of infiltration of glioma cells into healthy brain tissue and attributed partially to neuro-inflammatory processes.…”

Section: Cox-2 Inhibitors As Radiosensitizers and Radioprotectorssupporting

confidence: 66%

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

2016

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Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects on tumor tissue have been described for several compounds of this structurally diverse class. This review aims to substantiate the hypothesis that antioxidant COX-2 inhibitors are promising radioprotectants because of intercepting radiation-induced oxidative stress and inflammation in normal tissue, especially the vascular system. For this, literature reporting on COX inhibitors exerting radioprotective and/or radiosensitizing action as well as on antioxidant COX inhibitors will be reviewed comprehensively with the aim to find cross-points of both and, by that, stimulate further research in the field of radioprotective agents.

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Section: Cox-2 Inhibitors As Radiosensitizers and Radioprotectorssupporting

confidence: 66%

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

2016

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“…This has Pabst/Beranova-Giorgianni/Krueger been successful with indomethacin [122] or ibuprofen [123] to control fever and chills.…”

Section: Limitations Of Macrophage Activationmentioning

confidence: 99%

“…Besides their antitumor effects, muramyl peptides can also rebuild blood cell populations after chemotherapy or radiation [122]. This job is now done with recombinant cytokines.…”

Section: Resistance To Neoplasmsmentioning

confidence: 99%

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Effects of Muramyl Peptides on Macrophages, Monokines, and Sleep

Pabst

Beranová-Giorgianni

Krueger

1999

Neuroimmunomodulation

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Muramyl peptides are fragments of peptidoglycan from the cell walls of bacteria. Because of their unique chemistry, the immune system recognizes that muramyl peptides are products of bacteria, and it responds by becoming activated to resist infection. This resistance to infection is nonspecific, and extends to unrelated species of bacteria, fungi, and viruses. A key mechanism of the resistance to infection is activation of macrophages. Macrophage activation results in increased production of microbicidal oxygen radicals like superoxide and peroxide, and in increased secretion of inflammatory cytokines like interleukin-1β and tumor necrosis factor-α. These cytokines, besides activating neutrophils, B lymphocytes, and T lymphocytes, act on the central nervous system to induce physiological responses like fever and sleep. These physiological responses also aid in combating infection. Muramyl peptides also activate macrophages and other cells of the immune system to kill cancer cells. Muramyl peptides and similar agents will become more important as therapeutic agents in the future, due to increasing resistance of microbes to antibiotics, and increasing numbers of patients with immunodeficiencies.

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“…Moreover, diclofenac was observed to potentiate haematopoiesisstimulating effects of an immunomodulator glucan when the two drugs were administered concommitantly either before a single dose of gamma-rays [35] or before each radiation dose in repeatedly irradiated mice [36]. Mutually potentiating haematological effects were also found when diclofenac or indomethacin were given in a protective pre-irradiation regimen concurrently with immunomodulators muramyl tripeptide phosphatidylethanolamine [37,38] or broncho-vaxom [39]. Concommitant administration of indomethacin or diclofenac with the chemical radioprotectors cystamine or WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) was observed to enhance the haematopoiesis-stimulating efficiency of the chemical radiprotectors [40][41][42].…”

Section: Hematopoiesis and Non-selective Cyclooxygenase Inhibitorsmentioning

confidence: 99%

Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production — promising therapeutic strategy

Höfer

Pospı́šil

2006

Open Life Sciences

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Abstract:Inhibitors of prostaglandin production, designated as classical non-steroidal antiinflammatory drugs (NSAIDs) and acting on the base of non-selective inhibition of cyclooxygenases, have been found in numerous studies to potentiate recovery of perturbed haematopoiesis by removing the negative feedback control mediated by prostaglandins. However, classical NSAIDs show pronounced undesirable gastrointestinal side effects, which limits the possibility of their utilization for various pathophysiological states including myelosuppression. Specific cyclooxygenase-2 (COX-2) inhibitors, targeted at selective inhibition of this inducible cyclooxygenase isoform and having much better gastrointestinal side effect profile, have been found in recent studies to retain the haematopoiesisstimulating effects of classical NSAIDs. These results suggest that the indication spectrum of selective COX-2 inhibitors may be extended to the indication of myelosuppression of various etiology. Combining the anti-tumour and haematopoiesis-stimulating activities in a single COX-2 inhibitor may have a positive clinical impact.

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Combined modality radioprotection: enhancement of survival and hematopoietic recovery in gamma-irradiated mice by the joint use of liposomal muramyl tripeptide phosphatidylethanolamine (mtp-pe) and indomethacin

Cited by 14 publications

References 32 publications

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

Effects of Muramyl Peptides on Macrophages, Monokines, and Sleep

Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production — promising therapeutic strategy

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