Combined mapping of human auditory EEG and MEG responses

Huotilainen, Minna; Winkler, István; Alho, Kimmo; Escera, Carles; Virtanen, Juha; Ilmoniemi, Risto J.; Jä̈askëlainen, Iiro P.; Pekkonen, Eero; Näätänen, Risto

doi:10.1016/s0168-5597(98)00017-3

Cited by 134 publications

(92 citation statements)

References 39 publications

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“…The N1 and P2 dipoles localized to the supratemporal plane, consistent with generators in the primary and non-primary auditory cortices [10,11,16,22,[24][25][26]. It should be noted that the N1 and P2 activities are likely generated by several cortical sources and were not confined to one point as reported here.…”

Section: Discussionsupporting

confidence: 80%

“…Specifically, we aimed to clarify whether the enhanced P2 auditory evoked response in EEG compared to MEG reported for spectrally complex piano sounds by Shahin et al [13] can be accounted for by the presence of radial sources detected in EEG. Previous studies have shown imaging modality effects (differences and similarities between EEG and MEG) when investigating the N1 and P2 responses [3,[14][15][16]. Neukirch et al [3] showed that the N1 in EEG increased in amplitude and localized deeper as intensity of sounds increased, while the N1 in MEG localized more lateral with increased intensity of sounds and increased in amplitude initially and tended to plateau for the highest intensities.…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity of EEG and MEG to the N1 and P2 Auditory Evoked Responses Modulated by Spectral Complexity of Sounds

et al. 2007

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Acoustic complexity of a stimulus has been shown to modulate the electromagnetic N1 (latency ~110 ms) and P2 (latency ~190 ms) auditory evoked responses. We compared the relative sensitivity of electroencephalography (EEG) and magnetoencephalography (MEG) to these neural correlates of sensation. Simultaneous EEG and MEG were recorded while participants listened to three variants of a piano tone. The piano stimuli differed in their number of harmonics: the fundamental frequency (f 0 ), only,or f 0 and the first two or eight harmonics. The root mean square (RMS) of the amplitude of P2 but not N1 increased with spectral complexity of the piano tones in EEG and MEG. The RMS increase for P2 was more prominent in EEG than MEG, suggesting important radial sources contributing to the P2 only in EEG. Source analysis revealing contributions from radial and tangential sources was conducted to test this hypothesis. Source waveforms revealed a significant increase in the P2 radial source amplitude in EEG with increased spectral complexity of piano tones. The P2 of the tangential source waveforms also increased in amplitude with increased spectral complexity in EEG and MEG. The P2 auditory evoked response is thus represented by both tangential (gyri) and radial (sulci) activities. The radial contribution is expressed preferentially in EEG, highlighting the importance of combining EEG with MEG where complex source configurations are suspected.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Sensitivity of EEG and MEG to the N1 and P2 Auditory Evoked Responses Modulated by Spectral Complexity of Sounds

et al. 2007

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“…The dipole analysis was conducted by using a rotating dipole model (mirror dipoles). Seed points were set for all of the subjects in the same location in the bilateral superior temporal gyri (28)(29)(30). The maximal distance from the seed points was 30 mm, and the minimal distance between two dipoles was 90 mm.…”

Section: Methodsmentioning

confidence: 99%

Opposite patterns of hemisphere dominance for early auditory processing of lexical tones and consonants

Luo¹,

Ni²,

Li³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

133

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In tonal languages such as Mandarin Chinese, a lexical tone carries semantic information and is preferentially processed in the left brain hemisphere of native speakers as revealed by the functional MRI or positron emission tomography studies, which likely measure the temporally aggregated neural events including those at an attentive stage of auditory processing. Here, we demonstrate that early auditory processing of a lexical tone at a preattentive stage is actually lateralized to the right hemisphere. We frequently presented to native Mandarin Chinese speakers a meaningful auditory word with a consonant-vowel structure and infrequently varied either its lexical tone or initial consonant using an odd-ball paradigm to create a contrast resulting in a change in word meaning. The lexical tone contrast evoked a stronger preattentive response, as revealed by whole-head electric recordings of the mismatch negativity, in the right hemisphere than in the left hemisphere, whereas the consonant contrast produced an opposite pattern. Given the distinct acoustic features between a lexical tone and a consonant, this opposite lateralization pattern suggests the dependence of hemisphere dominance mainly on acoustic cues before speech input is mapped into a semantic representation in the processing stream.hemispheric specialization ͉ mismatch negativity ͉ preattentive auditory processing

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“…Specifically, the P1 is thought to be generated in the superior temporal gyrus, and is associated with auditory inhibition and sensory gating (Huotilainen, et al, 1998;Thoma, et al, 2003;Waldo, Gerhardt, Baker, Drebing, Adler, & Freedman, 1992). The N1 component is thought to reflect stimulus characteristics such as intensity and timing (Naatanen & Picton, 1987), and may be generated by activity in the superior temporal plane as well as other sources in the temporal and frontal lobes (Knight, Scabini, Woods, & Clayworth, 1988; Papanicolaou, Bau-mann, Rogers, Saydjari, Amparo, & Eisenberg, 1990;Scherg, Vajsar, & Picton, 1989).…”

Section: Author Manuscriptmentioning

confidence: 99%

“…Therefore, the P1-N1-P2 is particularly well suited for studying a number of acoustic cues important for the perception of speech, including silent gaps. These peaks occur approximately 50 ms (P1), 100 ms (N1), and 200 ms (P2) after stimulus onset and are thought to represent synchronous neural firing in the thalamic-cortical segment of the central auditory system in response to the onset of acoustic change (for review see Key, Dove, & Maguire, 2005; also Naatanen & Picton, 1987;Wolpaw & Penry, 1975;Woods, 1995).Specifically, the P1 is thought to be generated in the superior temporal gyrus, and is associated with auditory inhibition and sensory gating (Huotilainen, et al, 1998;Thoma, et al, 2003;Waldo, Gerhardt, Baker, Drebing, Adler, & Freedman, 1992). The N1 component is thought to reflect stimulus characteristics such as intensity and timing (Naatanen & Picton, 1987), and may be generated by activity in the superior temporal plane as well as other sources in the temporal and frontal lobes (Knight, Scabini, Woods, & Clayworth, 1988; Papanicolaou, Bau-mann, Rogers, Saydjari, Amparo, & Eisenberg, 1990;Scherg, Vajsar, & Picton, 1989).…”

mentioning

confidence: 99%

Cortical Evoked Response to Gaps in Noise: Within-Channel and Across-Channel Conditions

2007

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Objectives-The objective of this study was to describe the cortical evoked response to silent gaps in a group of young adults with normal hearing using stimulus conditions identical to those used in psychophysical studies of gap detection. Specifically, we sought to examine the P1-N1-P2 auditory evoked response to the onsets of stimuli (markers) defining a silent gap for withinchannel (spectrally identical markers) and across-channel (spectrally different markers) conditions using four perceptually-equated gap durations. It was hypothesized that (1) P1, N1, and P2 would be present and consistent for 1st marker (before the gap) onsets; (2) for within-channel markers, P1, N1, and P2 would be present for 2nd marker (after the gap) onsets only when the gap was of a duration equal to or larger than the behaviorally measured gap detection threshold; and (3) for the across-channel conditions, P1, N1, and P2 would be present for 2nd marker onsets regardless of gap duration. This is expected due to the additional cue of frequency change following the gap.Design-Twelve young adults (mean age 26 years) with normal hearing participated. Withinchannel and across-channel gap detection thresholds were determined using an adaptive psychophysical procedure. Next, cortical auditory evoked potentials (P1-N1-P2) were recorded with a 32-channel Neuro-scan™ electroencephalogram system using within-channel and acrosschannel markers identical to those used for the psychophysical task and four perceptually weighted gap durations: (1) individual listener's gap detection threshold; (2) above gap detection threshold; (3) below gap detection threshold; and (4) a 1-ms gap identical to the gap in the standard interval of the psychophysical task. P1-N1-P2 peak latencies and amplitudes were analyzed using repeated-measures analyses of variance. A temporal-spatial principal component analysis was also conducted.Results-The latency of P2 and the amplitude of P1, N1, and P2 were significantly affected by the acoustic characteristics of the 2nd marker as well as the duration of the gap. Larger amplitudes and shorter latencies were generally found for the conditions in which the acoustic cues were most salient (e.g., across-channel markers, 1st markers, large gap durations). Interestingly, the temporal-spatial principal component analysis revealed activity elicited by gap durations equal to gap detection threshold in the latency regions of 167 and 183 ms for temporal-parietal and rightfrontal spatial locations.Address for correspondence: Jennifer Lister, Department of Communication Sciences and Disorders, University of South Florida, 4202 E. Fowler Ave. PCD 1017, Tampa, FL 33620. jlister@cas.usf.edu.. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptConclusions-The cortical response to a silent gap is unique to specific marker characteristics and gap durations among young adults with normal hearing. Specifically, when the onset of the 2nd marker is perceptually salient, the amplitude of the P1-N1-P2 re...

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Combined mapping of human auditory EEG and MEG responses

Cited by 134 publications

References 39 publications

Sensitivity of EEG and MEG to the N1 and P2 Auditory Evoked Responses Modulated by Spectral Complexity of Sounds

Sensitivity of EEG and MEG to the N1 and P2 Auditory Evoked Responses Modulated by Spectral Complexity of Sounds

Opposite patterns of hemisphere dominance for early auditory processing of lexical tones and consonants

Cortical Evoked Response to Gaps in Noise: Within-Channel and Across-Channel Conditions

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