Combined lung‐sound and reflux‐monitoring: a pilot study of a novel approach to detect nocturnal respiratory symptoms in gastro‐oesophageal reflux disease

Kunsch, Steffen; Groß, Volker; Neeße, Albrecht; Sohrabi, Keyvan; Nell, Christoph; Gress, Thomas M.; Ellenrieder, Volker; Koehler, Ulrich

doi:10.1111/j.1365-2036.2010.04559.x

Cited by 14 publications

(12 citation statements)

References 42 publications

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“…As might be expected, studies using ambulatory acoustic systems to record cough sounds [38,39] have reported greater prevalence for both reflux-cough and cough-reflux associations than other techniques, such as manometry [20,21,40]. This is probably because it easier to identify single coughs using acoustic systems than manometry, where a single rapid pressure changes could represent either cough or artefact, such as clearing of the throat, and thus be rejected on a cautionary level by the observer.…”

Section: Introductionmentioning

confidence: 72%

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Smith

Houghton

2013

Cough

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Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed.

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Section: Introductionmentioning

confidence: 72%

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Smith

Houghton

2013

Cough

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“…However when the precise timing of cough and reflux events has been interrogated, up to 48% of patients with chronic cough display significant temporal associations (positive symptom association probability), with reflux events preceding cough more frequently than would be expected by chance alone [27–31]. These associations have been described for reflux events in the distal esophagus and therefore support the notion that a neuronal mechanism might explain the link between reflux and cough events.…”

Section: Jaclyn a Smith Against The Motionmentioning

confidence: 81%

“…Together with use of the SAP, these technologies greatly improve the objectivity of the analysis. All recent studies utilizing one or another variation of these enhancements have consistently demonstrated that in a substantial proportion of chronic cough patients (20–48%) cough follows reflux more frequently than expected by chance [27–31]. Furthermore, the pH of the reflux events preceding cough does not matter; reflux events of pH> 4 are equally important as those with pH italic>4 [30–31].…”

Section: Peter J Kahrilas For the Motionmentioning

confidence: 99%

“…All recent studies utilizing one or another variation of these enhancements have consistently demonstrated that in a substantial proportion of chronic cough patients (20–48%) cough follows reflux more frequently than expected by chance [27–31]. Furthermore, the pH of the reflux events preceding cough does not matter; reflux events of pH> 4 are equally important as those with pH italic>4 [30–31]. The most sophisticated and convincing of these studies (ironically published by my antagonist in this debate) enrolled chronic cough patients irrespective of concomitant diagnoses that might also explain cough and utilized acoustic monitoring coupled with computer analysis to detect coughs [30].…”

Section: Peter J Kahrilas For the Motionmentioning

confidence: 99%

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A Causal Relationship Between Cough and Gastroesophageal Reflux Disease (GERD) has been Established: A Pro/Con Debate

Kahrilas

Smith

Dicpinigaitis

2013

Lung

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Along with upper airway cough syndrome (formerly, postnasal drip syndrome) and eosinophilic airway inflammation (asthma, non-asthmatic eosinophilic bronchitis), gastroesophageal reflux disease (GERD) is generally considered among the most common etiologies of chronic cough. Indeed, cough management guidelines published by numerous respiratory societies worldwide recommend evaluation and treatment of GERD as an integral component of the diagnostic/therapeutic algorithm for the management of chronic cough. However, a significant number of patients with chronic cough presumed due to GERD do not report improvement despite aggressive acid-suppressive therapy. Some of these refractory cases may be due to the recently appreciated entity of non-acid or weakly acidic reflux. Further contributing to the controversy are recent studies demonstrating that patients with chronic cough do not have excessive reflux events relative to healthy volunteers. Although a temporal relationship between cough and reflux events has been suggested by studies utilizing impedance-pH monitoring of reflux events and objective cough recording, consensus is lacking in terms of whether this temporal relationship proves a causal link between reflux and cough. The 4th American Cough Conference, held in New York in June, 2013, provided an ideal forum for the debate of this issue between two internationally recognized experts in the field of reflux and chronic cough.

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“…(1) Various studies have supported this documentation and shown a relationship between these two disorders. (2,3) Chronic cough significantly affects the quality of life of these patients. (4) Case Report A 65 years old male presented with chronic cough, sputum and respiratory difficulty with repeated attacks of respiratory distress since 18 months having strong relationship with sleep and heavy meals.…”

Section: Introductionmentioning

confidence: 99%

Severe Bronchial asthma induced by Gastro esophageal reflux disease – a case report

2017

AGEMS

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Gastroesophageal events remain an important factor in the pathogenesis of patients with asthma with the reported prevalance ranging from 32-82%. The esophageal bronchial reflux plays a greater role in the pathophysiology of reflex associated cough. Gastroesophageal reflux either singly or in association with postnasal drip and or asthma is a thought to be a cause of chronic cough. People with asthma are twice as likely to have GERD as those people who don't have asthma. GERD may worsen asthma symptoms, however asthma and some asthma medications may worsen GERD symptoms. Although these two disorders often occur together, the relationship between GERD and asthma remains unclear.

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Combined lung‐sound and reflux‐monitoring: a pilot study of a novel approach to detect nocturnal respiratory symptoms in gastro‐oesophageal reflux disease

Cited by 14 publications

References 42 publications

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

A Causal Relationship Between Cough and Gastroesophageal Reflux Disease (GERD) has been Established: A Pro/Con Debate

Severe Bronchial asthma induced by Gastro esophageal reflux disease – a case report

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