2021
DOI: 10.1002/bit.27799
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Combined local delivery of tacrolimus and stem cells in hydrogel for enhancing peripheral nerve regeneration

Abstract: The application of scaffold-based stem cell transplantation to enhance peripheral nerve regeneration has great potential. Recently, the neuroregenerative potential of tacrolimus (a U.S. Food and Drug Administration-approved immunosuppressant) has been explored. In this study, a fibrin gel-based drug delivery system for sustained and localized tacrolimus release was combined with rat adipose-derived mesenchymal stem cells (MSC) to investigate cell viability in vitro. Tacrolimus was encapsulated in poly(lactic-c… Show more

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Cited by 9 publications
(4 citation statements)
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“…Hydrogel-based codelivery of MSCs and bioactive factors has also been applied for the treatment of nerve injuries. Fibrin hydrogels loaded with ADSCs and microspheres containing tacrolimus have been reported to enhance peripheral nerve regeneration via immunomodulatory actions [ 297 ]. In another study, on the basis of the acidic microenvironment at injury sites, pH-responsive IL-4 plasmid-loaded liposomes have been incorporated into PLA electrospun fibers to treat acute spinal cord injury (SCI) [ 292 ] (Fig.…”
Section: Biomaterials Involved In the Regulation Of The Immune Microe...mentioning
confidence: 99%
“…Hydrogel-based codelivery of MSCs and bioactive factors has also been applied for the treatment of nerve injuries. Fibrin hydrogels loaded with ADSCs and microspheres containing tacrolimus have been reported to enhance peripheral nerve regeneration via immunomodulatory actions [ 297 ]. In another study, on the basis of the acidic microenvironment at injury sites, pH-responsive IL-4 plasmid-loaded liposomes have been incorporated into PLA electrospun fibers to treat acute spinal cord injury (SCI) [ 292 ] (Fig.…”
Section: Biomaterials Involved In the Regulation Of The Immune Microe...mentioning
confidence: 99%
“…Moreover, researchers are gradually paying attention to the low survival rate of transplanted stem cells due to immune rejection, and are trying to use immunosuppressive agents in synergy with delivery platforms to improve the survival rate of transplanted stem cells and achieve therapeutic effects. Saffari and colleagues [ 106 ] designed a fibrin gel-based drug delivery platform. Tacrolimus was packed into poly (lactic-co-glycolic acid) (PLGA) microspheres and co-delivered with ADSCs in a hydrogel to the site of peripheral nerve injury for synergistic treatment.…”
Section: Hydrogels Combined With Stem Cells For Peripheral Nerve Injurymentioning
confidence: 99%
“…The delivery of antibiotics [ 194 , 195 , 196 , 197 , 198 ] and chemotherapeutics [ 199 , 200 , 201 , 202 , 203 , 204 ] using PLGA has been well-studied. Dopamine agonists [ 205 ], anticonvulsants [ 206 ], statins [ 207 ], and immunosuppressants [ 208 ] have also been delivered using PLGA. Furthermore, growth factors [ 209 ], various proteins [ 210 , 211 , 212 ], hormones [ 213 , 214 ], genetic material [ 215 ], and vaccines [ 216 ] have been delivered using PLGA.…”
Section: Synthetic Biopolymer Scaffolds For Therapeutic Ev Deliverymentioning
confidence: 99%