Combined light- and electron-microscopic study of the rat saphenous nerve

Alpsan, D.; Lal, S.

doi:10.1159/000145175

Cited by 7 publications

(11 citation statements)

References 15 publications

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“…Information on the size of fascicles of the saphenous nerve is not available in the literature, either for humans or for experimental animals. Despite that the number of myelinated fibers was described by Alpsan andLal (1980), Lynn (1984) and Carter and Lisney (1987), with similar values of the present study (Table 1), no information on the myelinated fiber density is yet described. In experimental studies, usually a small endoneural area is morphometrically investigated (Jakobsen and Lundbaek, 1976;Unger et al, 1998;Kovacic et al, 2003).…”

Section: Discussionsupporting

confidence: 72%

“…The only information available on the myelinated fiber distribution is that described by Alpsan and Lal (1980). These authors described a bimodal distribution, with peaks at 4.0 and 6.5 m in diameter.…”

Section: Discussionmentioning

confidence: 99%

“…Jeronimo et al (2005) also showed an unimodal distribution for the myelinated fibers of the sural nerves of rats aged 30 days. On the other hand, Alpsan and Lal (1980) also discussed that the methodology used for measurements of the myelinated fibers diameter also significantly influences the shape of the histogram. In the present study, the same methodology (semi-automated computer morphometry) used by Jeronimo et al (2005) was applied, what makes the present data comparable to the obtained in that study.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the same methodology (semi-automated computer morphometry) used by Jeronimo et al (2005) was applied, what makes the present data comparable to the obtained in that study. Alpsan and Lal (1980) used a totally manual technique to perform the morphometric study of the myelinated fiber. It is well known that manual morphometry is tedious, time consuming, difficult to perform correctly and subject to many sources of errors (Vita et al, 1992;Auer, 1994;Silva et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Alpsan and Lal (1980) described the number of the myelinated fibers of the adult rat saphenous nerve, as well as their diameter spectrum, with myelin thickness and g-ratio studies according to this spectrum. Nevertheless, no information about mean values for these parameters is available.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Morphometry of saphenous nerve in young rats

Campos¹,

Sanada²,

Sato³

et al. 2008

Journal of Neuroscience Methods

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Morphometry of saphenous nerve in young rats

Campos¹,

Sanada²,

Sato³

et al. 2008

Journal of Neuroscience Methods

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Specific paucity of unmyelinated C‐fibers in cutaneous peripheral nerves of the African naked‐mole rat: Comparative analysis using six species of bathyergidae

Smith

Purfürst

Grigoryan

et al. 2012

J of Comparative Neurology

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In mammalian peripheral nerves, unmyelinated C-fibers usually outnumber myelinated A-fibers. By using transmission electron microscopy, we recently showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber deficit manifested as a substantially lower C:A-fiber ratio compared with other mammals. Here we determined the uniqueness of this C-fiber deficit by performing a quantitative anatomical analysis of several peripheral nerves in five further members of the Bathyergidae mole-rat family: silvery (Heliophobius argenteocinereus), giant (Fukomys mechowii), Damaraland (Fukomys damarensis), Mashona (Fukomys darlingi), and Natal (Cryptomys hottentotus natalensis) mole-rats. In the largely cutaneous saphenous and sural nerves, the naked mole-rat had the lowest C:A-fiber ratio (∼1.5:1 compared with ∼3:1), whereas, in nerves innervating both skin and muscle (common peroneal and tibial) or just muscle (lateral/medial gastrocnemius), this pattern was mostly absent. We asked whether lack of hair follicles alone accounts for the C-fiber paucity by using as a model a mouse that loses virtually all its hair as a consequence of conditional deletion of the β-catenin gene in the skin. These β-catenin loss-of function mice (β-cat LOF mice) displayed only a mild decrease in C:A-fiber ratio compared with wild-type mice (4.42 compared with 3.81). We suggest that the selective cutaneous C-fiber deficit in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack of skin hair follicles. Possible mechanisms contributing to this unique peripheral nerve anatomy are discussed. J. Comp. Neurol. 520:2785–2803, 2012. © 2012 Wiley Periodicals, Inc.

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Nerve regenerating effect of short‐course administration of cyclosporine after fresh peripheral nerve allotransplantation in the rat: Comparison of nerve regeneration using different forms of donor nerve allografts

1995

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There is almost universal agreement that if cyclosporine (CsA), which is a potent immunosuppressant, is temporarily administered after surgery, regenerated axons will be maintained even after withdrawal of CsA following peripheral nerve allotransplantation. Thus, this experimental study was conducted to investigate whether a difference in donor nerve form, including thickness and length, influences nerve regeneration after withdrawal of immunosuppression with CsA. The findings suggest that as a result of immunosuppression with CsA, large-diameter nerve grafts are better able to induce nerve regeneration than small-diameter grafts, and after withdrawal of the immunosuppressant, thick nerve grafts are also better able to preserve regenerated axons against the rejection reaction than thin grafts. With regard to the length of the grafted nerve, short nerve allografts yield higher axon counts than long ones, the same as with autografts. The best way to induce nerve regeneration appears to be to transplant a short, thick nerve allograft, which is definitely capable of inducing many regenerated axons.

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Combined light- and electron-microscopic study of the rat saphenous nerve

Cited by 7 publications

References 15 publications

Morphometry of saphenous nerve in young rats

Morphometry of saphenous nerve in young rats

Specific paucity of unmyelinated C‐fibers in cutaneous peripheral nerves of the African naked‐mole rat: Comparative analysis using six species of bathyergidae

Nerve regenerating effect of short‐course administration of cyclosporine after fresh peripheral nerve allotransplantation in the rat: Comparison of nerve regeneration using different forms of donor nerve allografts

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