Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report

Hayashi, Satoshi; Kitada, Masahiro; Ishibashi, Keiichiro; Matsuda, Yoshinari; Miyokawa, Naoyuki

doi:10.1186/1477-7819-11-205

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…Combined large cell neuroendocrine carcinoma of the lungs with giant cell carcinoma is extremely rare, with a high malignant potential. [ 13 ] It has already been reported that malignant small round cell tumors are generally characterized by small, round and relatively undifferentiated cells. [ 14 ] This morphologic class of tumors contains representatives from almost all major categories of neoplasms, including carcinomas, sarcomas, lymphomas and neuroendocrine–neuroectodermal tumors.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphometric analysis of keratinized round cells in human oral carcinoma

Mohanta

Mohanty

Parida

2015

J Cytol

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Aim:During the present investigation, two types of keratinized round cells (KRCs), large keratinized round cells (LKRCs) and small keratinized round cells (SKRCs), were observed in the exfoliated buccal smears of oral cancer patients. Therefore, the aim of the present study was to determine the practical utility of KRCs during difficult diagnosis and in the early detection of oral squamous cell carcinoma (OSCC) through cytomorphometric analysis.Materials and Methods:In a hospital-based case control study, exfoliated scrape smears were collected from 136 patients clinically diagnosed as suffering from pre-cancerous lesions and OSCC and a parallel set of 136 samples were also collected from non-addicted and non-cancerous healthy individuals from different regions of Odisha, and this was considered as the control group. Wet-fixed smears were stained by adopting Papanicolaou's staining protocol and counter-stained with Giemsa's solution. One thousand cells were screened and keratinized round cells along with other cytological atypia were scored. Cytomorphometry was carried out using a computer-assisted Cat Cam 1.30 (1.3 Mega Pixel) microscope camera. The findings were statistically analyzed and interpreted with respect to oral sites, age groups and sexes.Results:Cytomorphometrically, the nucleus to cytoplasmic ratio of the LKRCs was 1:4.7 in males and 1:4.3 in females, and in SKRCs it was calculated to be 1:4.6 in males and 1:5.2 in females.Conclusion:Cellular keratinization, hyperchromasia and increased N/C ratios in both LKRCs and SKRCs indicates the state of malignancy and thus the present finding has a practical value in early detection and diagnosis of OSCC patients.

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Section: Discussionmentioning

confidence: 99%

Cytomorphometric analysis of keratinized round cells in human oral carcinoma

Mohanta

Mohanty

Parida

2015

J Cytol

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“…In support of this, mere case reports exist in the literature. 6 , 7 Given the lack of any large series of reports, our study represents a good resource for the study of this rare disease.…”

Section: Discussionmentioning

confidence: 99%

“…The mixed form of NET in the lung is rarely discussed, and to the best of our knowledge, mere case reports are available. 6 , 7 In this report, we conducted a retrospective study to analyze the clinical features, occurrence, treatment, and prognosis of these patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of the mixed form of neuroendocrine tumor in the lung: A retrospective study in 2501 lung cancer cases

Wang

Chen

et al. 2015

Thoracic Cancer

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BackgroundA neuroendocrine tumor (NET) is a special kind of epithelial tumor with predominant neuroendocrine differentiation, which arises throughout the body, including the lung. A subpopulation of lung cancer patients suffer from the mixed (combined) form of NET with components of non-neuroendocrine carcinoma. However, the clinical characteristics of the mixed form of NET are not well established.MethodsWe analyzed 2501 consecutive cases of primary lung cancer from 2009 to 2011. The diagnosis, histology, therapy, and outcome were collected.ResultsA total of 22 patients were enrolled. The occurrence rate of lung cancer was 0.9%. Neither gender (1.2% and 0.3% for male and female, respectively, P = 0.35) nor age (0.6% and 1.3% for patients aged ≤60 and >60, respectively, P = 0.13) was associated with the onset of this disease; however it has become more frequent in recent years (0.6% and 1.6% at the time ≤ and >2010 respectively, P = 0.03). This cohort of 22 patients had a median survival of 60.0 months (95% confidence interval: 14.3–105.6 months). Patients with metastatic disease (60 months and not reached [NR], P = 0.18) or a small-cell lung cancer component tended to have a shorter survival (35 months and NR, P = 0.16). Patients who underwent surgery had a significantly longer survival period (NR and 17.0 months, P = 0.001).ConclusionsA mixed form of NET in the lung is a rare disease. While stage and histology might influence prognosis, surgery is the critical factor for long-term survival.

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“…As 2 O 3 shows polyploid cells and giant cells; whereas, metanil yellow documents no polyploid cells but with variable shaped giant cells suggesting that endoreduplication may not be the cause of giant cell formation. Hayashi et al (2013) opined that giant cells are the outcome of chaotic mitotic activity due to physiological stresses. Furthermore, such cells are not observed in any squash preparation of untreated control.…”

Section: Cytotoxicity Induced By Arsenic Trioxide and Metanil Yellowmentioning

confidence: 99%

Assessment of Cytotoxicity Induced by Heavy Metal Arsenic Trioxide and Azo-Dye Metanil Yellow in <i>Allium cepa</i> Assay and Aqueous Plant Extracts Mediated Amelioration

et al. 2019

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Allium cepa (2n=16) assay is used to determine cytotoxicity of environmental pollutants like heavy metal arsenic (in the form of arsenic trioxide concentration used: 0.010, 0.050, 0.075 and 0.100 mg L 1 for 24 h duration) and azo-dye metanil yellow (concentration used: 100, 150, 200 and 400 mg L 1 for 24 h duration) with an objective to understand the toxic effects of the test materials on cells and chromosomes of a plant-based system. Assessment of cytotoxicity reveals that arsenic trioxide can induce chromosomal breakages, affects spindle organization and causes cellular metabolic defects; whereas, metanil yellow predominantly affects cellular metabolism. Cytological disturbances are mostly dose-dependent, and arsenic trioxide depicts pronounced effectivity in inducing mitotic aberrations in root tip cells of A. cepa than metanil yellow (in relation to employed doses). Furthermore, aqueous plant extracts (used due to its operational simplicity and cost-effectivity) of the leaf (Coriandrum sativum L., Ocimum tenuiflorum L., and Pteris vittata L.) and seed (Nigella sativa L.) samples are used to ascertain their amelioration potentiality against the environmental toxicants. The ameliorative study (decrement in their observed values) involves attributes like mitotic index, total abnormal dividing cell frequency and frequency of giant and anucleate cells in resting stages. Results suggest that all the employed extracts are ameliorative, and can be explored further for their role in bioremediation.

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Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report

Cited by 11 publications

References 9 publications

Cytomorphometric analysis of keratinized round cells in human oral carcinoma

Cytomorphometric analysis of keratinized round cells in human oral carcinoma

Clinical characteristics of the mixed form of neuroendocrine tumor in the lung: A retrospective study in 2501 lung cancer cases

Assessment of Cytotoxicity Induced by Heavy Metal Arsenic Trioxide and Azo-Dye Metanil Yellow in <i>Allium cepa</i> Assay and Aqueous Plant Extracts Mediated Amelioration

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