Combined Lamivudine and Interferon-α Therapy for Chemotherapy-Induced Reactivation of Hepatitis B Virus

Hepatitis B virus (HBV) reactivation is a frequent complication in inactive HBV carriers at time of chemotherapy or following this chemotherapy. This complication appeared during or after chemotherapy and was not increased by the use of rituximab alone or combined with chemotherapy. This is a severe complication most frequently seen in lymphoma patients. Lamivudine have efficacy to treat the patients once the clinical disease is present. However, lamivudine prophylaxis beginning before chemotherapy and until at least 6 months after the end of chemotherapy is recommended for all HBV carriers. Hepatitis C virus is usually not associated with reactivation and prophylaxis should not be used.

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Adefovir Dipivoxil to Prevent Exacerbation of Lamivudine-resistant Hepatitis B Infection during Chemotherapy for Non-Hodgkin's Lymphoma

Enomoto

Nishiguchi

Seki

et al. 2004

Am J Gastroenterology

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Combined Lamivudine and Interferon-α Therapy for Chemotherapy-Induced Reactivation of Hepatitis B Virus

Cited by 3 publications

References 10 publications

Hepatitis B Virus Reactivation After Cytotoxic Chemotherapy: The Disease and Its Prevention

Hepatitis B Virus Reactivation After Cytotoxic Chemotherapy: The Disease and Its Prevention

Hepatitis B Virus Reactivation in Patients Receiving Chemotherapy for Cancer Treatment: Role of Lamivudine Prophylaxis

Adefovir Dipivoxil to Prevent Exacerbation of Lamivudine-resistant Hepatitis B Infection during Chemotherapy for Non-Hodgkin's Lymphoma

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