Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies
Chinmaya U. Joisa,
Kevin A. Chen,
Samantha Beville
et al.
Abstract:Protein kinases are a primary focus in targeted therapy development for cancer, owing to their role as regulators in nearly all areas of cell life. Kinase inhibitors are one of the fastest growing drug classes in oncology, but resistance acquisition to kinase-targeting monotherapies is inevitable due to the dynamic and interconnected nature of the kinome in response to perturbation. Recent strategies targeting the kinome with combination therapies have shown promise, such as the approval of Trametinib and Dabr… Show more
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