Combined Kidney-Islet Transplantation

Cavallari, Giuseppe; Neri, Flavia; Nardo, Bruno

doi:10.5772/17641

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Understanding the Complexities of Kidney Transplantation 2011

DOI: 10.5772/17641

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Combined Kidney-Islet Transplantation

Giuseppe Cavallari¹,

Flavia Neri²,

Bruno Nardo³

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2014

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Cited by 1 publication

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Pancreas Versus Islets After a Successful Kidney Transplant

2014

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The optimal endocrine transplant that should follow a successful kidney transplant in patients with type 1 diabetes is currently open to debate. Ideally, a combined kidney and pancreas transplant is carried out simultaneously from an optimal donor as there is clear immunological benefit. However, when a living donor kidney transplant occurs initially, either a pancreas after kidney or islet after kidney transplant may be considered. A pancreas after kidney transplant carries more surgical risk but provides more robust endocrine reserve compared to the alternative option of islet after kidney transplantation. Furthermore, islet transplantation is not universally available, requires specialized manufacturing facilities, and the costs associated with islet manufacture may not be reimbursable by healthcare. From a patient's perspective, however, islet after kidney transplantation is a highly attractive option to avoid further surgical risk and recovery. This paper discusses the merits and demerits of these alternative transplant options, and debates both competitive aspects and complementarity. We discuss current outcomes and ongoing clinical trials.

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Pancreas Versus Islets After a Successful Kidney Transplant

2014

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Combined Kidney-Islet Transplantation

Cited by 1 publication

References 40 publications

Pancreas Versus Islets After a Successful Kidney Transplant

Pancreas Versus Islets After a Successful Kidney Transplant

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