Combined intrathymic and intravenous injection of mesenchymal stem cells can prolong the survival of rat cardiac allograft associated with decrease in miR-155 expression

Huang, Haoyue; He, Jigang; Teng, Xiaochun; Yang, Yunsheng; Ye, Wenxue; Hu, Yanqiu; Shen, Zhenya

doi:10.1016/j.jss.2013.06.015

Cited by 18 publications

(15 citation statements)

References 31 publications

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“…Bartholomew et al [75] first reported that using MSCs can prolong skin graft survival in organ transplantation. In rat and primate models, MSCs can effectively suppress immune rejection; induce immune tolerance; and prolong graft survival in the liver, heart, kidney, pancreas, and other solid organs for transplantation [76][77][78] . These results might result from the shifting of the Th1/Th2 cell balance in favor of the latter, thereby increasing the level of Tregs and inhibiting the function of DCs through MSCs.…”

Section: Paracrine Actionmentioning

confidence: 99%

Mesenchymal stem cells: Potential role in corneal wound repair and transplantation

Li¹

2014

WJSC

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Corneal diseases are a major cause of blindness in the world. Although great progress has been achieved in the treatment of corneal diseases, wound healing after severe corneal damage and immunosuppressive therapy after corneal transplantation remain problematic. Mesenchymal stem cells (MSCs) derived from bone marrow or other adult tissues can differentiate into various types of mesenchymal lineages, such as osteocytes, adipocytes, and chondrocytes, both in vivo and in vitro . These cells can further differentiate into specific cell types under specific conditions. MSCs migrate to injury sites and promote wound healing by secreting anti-inflammatory and growth factors. In addition, MSCs interact with innate and acquired immune cells and modulate the immune response through their powerful paracrine function. Over the last decade, MSCs have drawn considerable attention because of their beneficial properties and promising therapeutic prospective. Furthermore, MSCs have been applied to various studies related to wound healing, autoimmune diseases, and organ transplantation. This review discusses the potential functions of MSCs in protecting corneal tissue and their possible mechanisms in corneal wound healing and corneal transplantation.

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Section: Paracrine Actionmentioning

confidence: 99%

Mesenchymal stem cells: Potential role in corneal wound repair and transplantation

Li¹

2014

WJSC

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“…According to Huang et al . reported that combined intrathymic and intravenous injections of mesenchymal stem cells can prolong the survival of rat cardiac allografts, which may be associated with down-regulating miR-155 expression, a shift in the Th1/Th2 balance, and up-regulation of Treg cells expression9. Li F et al .…”

Section: Discussionmentioning

confidence: 99%

“…Huang H et al . reported that a combination of intrathymic and intravenous injections of mesenchymal stem cells can prolong the survival of rat cardiac allografts9. Studies of liver transplantations have found that some hosts were tolerant to grafts and no longer needed immunosuppressive agents after liver transplantation1011.…”

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confidence: 99%

Treatment of surgical brain injury by immune tolerance induced by intrathymic and hepatic portal vein injection of brain antigens

Yang

Liu

et al. 2016

Sci Rep

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Surgical brain injury (SBI) defines complications induced by intracranial surgery, such as cerebral edema and other secondary injuries. In our study, intrathymic and hepatic portal vein injection of allogeneic myelin basic protein (MBP) or autogeneic brain cell suspensions were administered to a standard SBI model. Serum pro-inflammatory IL-2, anti-inflammatory IL-4 concentrations and the CD4+T/CD8+T ratio were measured at 1, 3, 7, 14 and 21 d after surgery to verify the establishment of immune tolerance. Furthermore, we confirmed neuroprotective effects by evaluating neurological scores at 1, 3, 7, 14 and 21 d after SBI. Anti-Fas ligand (FasL) immunohistochemistry and TUNEL assays of brain sections were tested at 21 d after surgery. Intrathymic injections of MBP or autogeneic brain cell suspensions functioned by both suppressing secondary inflammatory reactions and improving prognoses, whereas hepatic portal vein injections of autogeneic brain cell suspensions exerted a better effect than MBP. Intrathymic and hepatic portal vein injections of MBP had equal effects on reducing secondary inflammation and improving prognoses. Otherwise, hepatic portal vein injections of autogeneic brain cell suspensions had better outcomes than intrathymic injections of autogeneic brain cell suspensions. Moreover, the benefit of injecting antigens into the thymus was outweighed by hepatic portal vein injections.

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“…On the other hand, intracoronary injection route may also impact stem cell survival by causing poor initial cell retention in the myocardial tissue, however it causes minimal inflammation [53]. In addition, intravenous injection does not allow proper cell recruitment into the heart, consequently providing inadequate cell number; however combined intravenous and intrathymic injection has been shown to prolong survival of cardiac allograft [54]. Although, epicardial placement of ‘cell sheets’ allows successful cell engraftment, defective integration into cardiac tissue appears to be a major problem that may influence long term cell viability.…”

Section: The Strategy Of Cell Transplantationmentioning

confidence: 99%

Stem cell death and survival in heart regeneration and repair

Abdelwahid¹,

Kalvelytė

Stulpinas

et al. 2015

Apoptosis

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Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart failure. Delineating the regulatory signaling pathways that orchestrate cell survival in the heart has significant therapeutic implications. Cardiac tissue has limited capacity to regenerate and repair. Stem cell therapy is a successful approach for repairing and regenerating ischemic cardiac tissue; however, transplanted cells display very high death percentage, a problem that affects success of tissue regeneration. Stem cells display multipotency or pluripotency and undergo self-renewal, however these events are negatively influenced by upregulation of cell death machinery that induces the significant decrease in survival and differentiation signals upon cardiovascular injury. While efforts to identify cell types and molecular pathways that promote cardiac tissue regeneration have been productive, studies that focus on blocking the extensive cell death after transplantation are limited. The control of cell death includes multiple networks rather than one crucial pathway, which underlies the challenge of identifying the interaction between various cellular and biochemical components. This review is aimed at exploiting the molecular mechanisms by which stem cells resist death signals to develop into mature and healthy cardiac cells. Specifically, we focus on a number of factors that control death and survival of stem cells upon transplantation and ultimately affect cardiac regeneration. We also discuss potential survival enhancing strategies and how they could be meaningful in the design of targeted therapies that improve cardiac function.

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Combined intrathymic and intravenous injection of mesenchymal stem cells can prolong the survival of rat cardiac allograft associated with decrease in miR-155 expression

Cited by 18 publications

References 31 publications

Mesenchymal stem cells: Potential role in corneal wound repair and transplantation

Mesenchymal stem cells: Potential role in corneal wound repair and transplantation

Treatment of surgical brain injury by immune tolerance induced by intrathymic and hepatic portal vein injection of brain antigens

Stem cell death and survival in heart regeneration and repair

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