Combined intra-arterial infusion and systemic chemoradiotherapy for stage IV squamous cell carcinoma of the mandibular gingiva

Nakasato, Tatsuhiko; Izumisawa, Mitsuru; Akahane, Akio; Kikuchi, Kazuko; Ehara, Shigeru; Shoji, Satoru; Kogi, Shintaro; Mizuki, Harumi; Sugiyama, Yoshiki

doi:10.1007/s11604-012-0122-3

Cited by 7 publications

(10 citation statements)

References 26 publications

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“…For CIS, the first dose consisted of 5 mg/kg and the second 2.5 mg/kg (Havelka, Berndtsson, Olofsson, Shoshan, & Linder, ). These doses were a proportional adaptation to rats from the protocol used for cancer treatment in humans, which is determined by body surface (FDA; Nakasato et al., ).…”

Section: Methodsmentioning

confidence: 99%

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Cisplatin chemotherapy impairs the peri‐implant bone repair around titanium implants: An in vivo study in rats

Matheus

Ervolino

Faleiros

et al. 2017

J Clinic Periodontology

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Section: Methodsmentioning

confidence: 99%

“…I G U R E 1 Clinical images showing the exposure of the tibial metaphysis (a), the drilled alveolus (b), the implant insertion (c) and bicortical fixation of the implant with sufficient amount of bone at the site (d) , which is determined by body surface (FDA;Nakasato et al, 2012).…”

mentioning

confidence: 99%

Cisplatin chemotherapy impairs the peri‐implant bone repair around titanium implants: An in vivo study in rats

Matheus

Ervolino

Faleiros

et al. 2017

J Clinic Periodontology

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show abstract

“…Nakasato et al 23 reported a survival rate of 70% at 5 years for SCC. However, this rate decreases to 30.8% in the presence of metastases in the regional lymph area 24 .…”

Section: Palate Cancermentioning

confidence: 99%

Survival and mortality from oral cancer by anatomical location. A narrative review.

Candia¹,

Fernández²,

Kraemer³

2016

J Oral Res

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“…Gingival SCC is relatively rare and represents < 10% of all oral cancers in the United States [14] , while gingival SCC is the second-most common oral cancer in Japan [15] . Surgical resection (marginal or segmental mandibulectomy) for SCC of the mandible is usually the preferred primary treatment because systemic chemotherapy is regarded as inadequate against a tumor with extensive bone destruction [16] . Despite clinical trials of various treatment strategies, prognosis and locoregional control remain poor in advanced cases of SCC in the mandible because involvement of the retromandibular trigone is more likely to be associated with multidirectional invasion [16] .…”

Section: Introductionmentioning

confidence: 99%

Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in predicting pathological response to preoperative super-selective intra-arterial chemoradiotherapy for advanced squamous cell carcinoma of the mandible

Shibasaki

Iwai

Oguri

et al. 2018

Journal of Bone Oncology

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IntroductionAlthough chemoradiotherapy (CRT) for oral squamous cell carcinoma (SCC) has been shown to preserve organ function and improve cosmetic results, site-specific data, especially mandible, are limited. The aim of this study was to evaluate the predictability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on response to super-selective intra-arterial CRT for advanced SCC of the mandible.MethodsFifteen patients with advanced SCC of the mandible underwent super-selective intra-arterial CRT followed by radical resection. Maximum standardized uptake value (SUVmax) of the mandibular lesion was evaluated with FDG-PET/CT before and after CRT. The SUVmax before and after CRT was defined as pre-SUVmax and post-SUVmax, respectively. The difference between pre- and post-SUVmax was calculated as SUVmax reduction rate to evaluate treatment response of the mandibular lesion. Each SUVmax reduction rate and surgical specimen of the corresponding lesion was analyzed to evaluate an accuracy of the modality for predicting pathological response.ResultsThe median of pre-SUVmax was significantly lower than that of post-SUVmax (p = 0.001). Of the 15 patients, 6 had a pathological complete response (pCR) and 9 had a non-pCR. Neither pCR patients nor non-pCR patients showed significant difference of the median of SUVmax between pre- and post-CRT (pre-CRT p = 0.099 post-CRT p =0.074). The SUVmax reduction rate in patients with pCR was significantly higher than that with non-pCR (p = 0.002). Receiver operating characteristic analysis revealed that the optimal cut-off point of the reduction rate was 64.7%, with 83% sensitivity and 100% specificity.ConclusionsThese results concluded that SUVmax reduction rate can predict pathological complete response of preoperative super-selective intra-arterial CRT for advanced SCC of the mandible.

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Combined intra-arterial infusion and systemic chemoradiotherapy for stage IV squamous cell carcinoma of the mandibular gingiva

Abstract: Combined intra-arterial infusion and systemic chemoradiotherapy may be an effective treatment for patients with stage IV mandibular gingival cancer.

Cited by 7 publications

References 26 publications

Cisplatin chemotherapy impairs the peri‐implant bone repair around titanium implants: An in vivo study in rats

Cisplatin chemotherapy impairs the peri‐implant bone repair around titanium implants: An in vivo study in rats

Survival and mortality from oral cancer by anatomical location. A narrative review.

Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in predicting pathological response to preoperative super-selective intra-arterial chemoradiotherapy for advanced squamous cell carcinoma of the mandible

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