Combined Infiltrative Macroscopic Growth Pattern and Infiltrative Microscopic Tumor Border Status Is a Novel Surrogate Marker of Poor Prognosis in Patients With Pancreatic Neuroendocrine Tumor

Ahn, Bokyung; Kim, Joo Young; Hong, Seung‐Mo

doi:10.5858/arpa.2021-0475-oa

Cited by 2 publications

(1 citation statement)

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“…In the current study, tumor cells in the inner nodule showed an infiltrative growth pattern. One recent study has reported a microscopic infiltrative tumor border in about 40% of surgically resected PanNETs, which was associated with higher tumor grades, larger tumors, more metastatic lymph nodes, higher American Joint Committee on Cancer stage groups, and the presence of lymphovascular and perineural invasions [ 7 ]. However, the clinicopathologic significance of a microscopic infiltrative tumor border in a PNEMT is currently unknown.…”

Section: Discussionmentioning

confidence: 99%

Malignant potential of neuroendocrine microtumor of the pancreas harboring high-grade transformation: lesson learned from a patient with von Hippel-Lindau syndrome

Lee,

Hwang

et al. 2024

J Pathol Transl Med

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Pancreatic neuroendocrine microtumor (PNEMT) is a neuroendocrine tumor (NET) < 0.5 cm in diameter, and it is considered benign. We report a PNEMT with high-grade transformation (HGT). A man in his 60s with von Hippel-Lindau syndrome underwent surgical resection of a NET. A second sub-centimeter nodule with a nodule-in-nodule pattern was discovered. The 0.4 cm outer nodule contained clear columnar cells with round nuclei and indistinct nucleoli, while the 0.1 cm inner nodule had eosinophilic cells with an increased nuclear to cytoplasmic ratio, vesicular nuclei, and prominent nucleoli. Tumor cells in the outer and inner nodules were synaptophysin and chromogranin positive. Only the inner nodule was p53 positive, while the outer nodule was exclusively positive for carbonic anhydrase 9 and vimentin. The Ki-67 labeling indices for the outer and inner nodules were 2.1% (grade 1) and 44.3% (grade 3), respectively. This nodule was determined to be a PNEMT with HGT. Our findings suggest that a PNEMT may not always be benign and can undergo HGT.

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Section: Discussionmentioning

confidence: 99%