COMBINED IgG2, IgG4 AND IgA DEFICIENCY: LOW C1Q CONCENTRATIONS AND THE PRESENCE OF EXCESS C1R AND C1S IN AN ADULT PATIENT WITH RECURRENT PNEUMOCOCCAL INFECTIONS
Abstract:The complement (C) profile was investigated in an adult patient with combined IgG2, IgG4 and IgA deficiency and recurrent pneumococcal infections. The analysis revealed no gross impairment of the classic and alternative pathways of C activiation. However, the concentrations of circulating C1q were persistently decreased, and the sera contained an excess of C1r‐C1s complexes, resembling the C1 aberrations previously found in children with recurrent acute otitis media. The concentrations of C4 in the patient wer… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.