Combined IgA and alpha-1-antitrypsin deficiency in a boy with severe respiratory tract infections and asthma

Østergaard, Poul Aabel

doi:10.1007/bf00442338

Eur J Pediatr

1982

DOI: 10.1007/bf00442338

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Combined IgA and alpha-1-antitrypsin deficiency in a boy with severe respiratory tract infections and asthma

Poul Aabel Østergaard

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1984

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Cited by 3 publications

References 11 publications

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Alpha-1-antitrypsin levels and clinical symptoms in forty-eight children with selective IgA deficiency

Østergaard

1984

Eur J Pediatr

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Previous studies in adult patients with selective IgA deficiency have pointed towards a possible connection between combined IgA and alpha-1-antitrypsin deficiency and the development of bronchiectasis. Thus, investigations were conducted of serum alpha-1-antitrypsin levels and clinical symptoms in 48 children with selective IgA deficiency. However, alpha-1-antitrypsin deficiency was not found in this group of patients. Furthermore, radiographic signs of recurrent pneumonia restricted to certain fields of the lungs, suggestive of bronchiectasia, were not observed in the patients. Thus, although a highly selected group of children with selective IgA deficiency was studied, a connection between IgA deficiency and alpha-1-antitrypsin deficiency was not obvious.

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Alpha-1-antitrypsin levels and clinical symptoms in forty-eight children with selective IgA deficiency

Østergaard

1984

Eur J Pediatr

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The IgA immune system in epileptics on anticonvulsant therapy

Meissner

Joubert

et al. 1984

Eur J Clin Pharmacol

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Disturbances in IgA have often been reported in white epileptics on anticonvulsant therapy. The clinical significance of these disorders is of interest as this aspect does not appear to have been sufficiently explored. In a previous study neither African nor Caucasian epileptics on treatment showed a deficiency of serum IgA. Since secretory IgA is the main defence factor in protecting mucosal surfaces, the object of the present study was simultaneously to determine serum and salivary IgA in suitable subjects and to monitor related clinical events. A similar elevation of salivary IgA level was found in Black and White epileptics on treatment. Clinical events were rare and were not related either to serum or secretory IgA concentrations. It is concluded that at present epileptics do not seem to require special immunological or clinical monitoring.

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The IgA immune system in epileptics on anticonvulsant therapy

Meissner

Joubert

et al. 1984

Eur J Clin Pharmacol

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Combined IgA and alpha-1-antitrypsin deficiency in a boy with severe respiratory tract infections and asthma

Cited by 3 publications

References 11 publications

Alpha-1-antitrypsin levels and clinical symptoms in forty-eight children with selective IgA deficiency

Alpha-1-antitrypsin levels and clinical symptoms in forty-eight children with selective IgA deficiency

The IgA immune system in epileptics on anticonvulsant therapy

The IgA immune system in epileptics on anticonvulsant therapy

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