Abstract:Rapid and accurate detection of MTB (Mycobacterium tuberculosis) is key to eliminating tuberculosis. Metagenomic sequencing combining host depletion can significantly improve the diagnostic performance for tuberculosis. Here we compared the performance for diagnosis of 98 suspected pulmonary tuberculosis (PTB) among mycobacterial culture, Xpert, metagenomic next-generation sequencing (mNGS), mNGS of depletion human DNA (mNGS-DH), and nanopore sequencing of depletion human DNA (Nanopore-DH). In the 82 cases of … Show more
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