Combined hamartoma of the retina and retinal pigment epithelium

Abstract

We report two cases of combined hamatoma of the retina and retinal pigment epithelium (CHR-RPE), illustrated with ultrasonography, optical coherence tomography, fundus fluorescein angiography and indocyanine green angiography images. CHR-RPE could clinically mimic several other retinal conditions. Failure to distinguish it from serious malignancies such as choroidal melanoma or retinoblastoma has led to unnecessary enucleation in the past. Through these case reports and a review of literature, we show the diagnostic features of CHR-RPE, its key differential diagnoses and the management options.

Combined hamartoma of the retina and retinal pigment epithelium – MRI features of a rare paediatric intraocular tumour

“…It consists of a proliferation of glial and vascular elements in combination with sheets of pigmented epithelial cells. 2,3 Punctate foci of calcification have been reported in longstanding disease. Variations in the relative proportions of these components contribute to a heterogeneous clinical appearance.…”