Combined folliculotropic/syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications

Jacobs, Micah A.; Kocher, William; Murphy, Gëorge F.

doi:10.1016/s0046-8177(03)00401-5

Cited by 21 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Folliculotropic MF is considered to be a closely related condition, as some cases of syringotropic MF demonstrate lymphocytic infiltration involving both eccrine glands and hair follicles (23,24). On the other hand, lymphoid infiltrates around the eccrine glands without syringometaplasia can be observed in biopsies of conventional MF usually in the tumour stage (22,25,26).…”

Section: Discussionmentioning

confidence: 99%

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hattori¹,

Uchiyama²,

Tago³

et al. 2013

Acta Derm Venerol

View full text Add to dashboard Cite

Mycosis fungoides usually follows an indolent clinical course. We report here a rapidly progressive case of mycosis fungoides with peculiar clinical and histological features, presenting as a haematoma-like mass on the thigh accompanied by multiple reddish brown erythematous lesions on the trunk and extremities. Histopathologically, the erythematous lesions showed epidermotropism of atypical T lymphocytes expressing CD4 and prominent syringotropism without syringometaplasia. The haematoma-like lesion consisted of diffuse and dense infiltrates of medium-to-large-sized pleomorphic lymphocytic cells expressing CD30, suggesting that CD30+ large-cell transformation had occurred. Mycosis fungoides presenting as a haematoma-like lesion is rare and may be a poor prognostic sign.

show abstract

Section: Discussionmentioning

confidence: 99%

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hattori¹,

Uchiyama²,

Tago³

et al. 2013

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

“…9,14 As far as eccrine/ apocrine units are concerned, their infiltration and some degree of hyperplasia can be encountered in the so-called syringotropic variant, sometimes with the appearances reminiscent of a spiradenoma. 6,15,37,42 Syringotropic infiltrates and syringometaplasia have been reported in lymphomatoid papulosis. 12 Marginal zone lymphoma is another entity wherein so-called lymphoepithelial lesions can be seen, 35 but these can also occur in pseudolymphomas.…”

mentioning

confidence: 99%

Hyperplasia of Hair Follicles and Other Adnexal Structures in Cutaneous Lymphoproliferative Disorders

Kazakov¹,

Белоусова

Kacerovská³

et al. 2008

American Journal of Surgical Pathology

View full text Add to dashboard Cite

We studied 53 cutaneous lymphoproliferative disorders, all of which manifested hair follicle hyperplasia. There were 42 cases conforming to the description of pseudolymphomatous folliculitis (PLF) and 11 cases of authentic lymphomas including mycosis fungoides, CD30+ anaplastic large cell lymphoma, diffuse large B-cell lymphoma, B-cell small cell lymphoma/leukemia, and peripheral T-cell lymphoma, not otherwise specified. All patients with PLF clinically presented with a solitary nodule preferentially involving the face. Beside hair follicle hyperplasia, the typical features were a dense infiltrate of small well-differentiated lymphocytes, lymphoplasmacytoid cells, plasma cells, and epithelioid histiocytes forming tiny granulomas. Some unusual or worrisome features recognized included eccrine/apocrine duct hyperplasia, subcutis/muscle infiltration, lymphocyte "smudging," single file infiltration, and large atypical cells. Immunohistochemically, T-cell predominant cases dominated in the series. All 34 tested cases revealed a polyclonal pattern of kappa and lambda immunoglobulin (Ig) light chain expression. In 4 cases, scattered CD30+ cells were identified. Monoclonal rearrangements of T-cell receptor (TCR) and IgH genes were detected in 19 and 3 cases respectively, including 1 case with dual T-cell receptor/IgH rearrangement. Three of 30 tested cases proved positive for herpes simplex virus-1, whereas herpes simplex virus-2 always tested negative. Of 31 cases tested for Borrelia burgdorferi, 30 specimens were negative. In 9 cases, fluorescent in situ hybridization for t(11;18) and t(14;18) revealed none of the above translocations. The most common treatment modality was surgical removal. Forty patients with a mean follow-up of 3.7 years included 39 patients with no evidence of disease and 1 individual with local recurrence. The comparison of "clonal cases of PLF" and those with polyclonal population or in which clonality remained undetermined revealed no differences between the 2 groups in the clinical presentation, pathologic, and immunohistochemical features. We conclude that hyperplasia of hair follicles and other adnexa can be seen not only in the condition currently known as PLF, but also in genuine cutaneous lymphomas and may be just a happenstance secondary to a basic pathologic process.

show abstract

“…3,4 It is reported that SCTCL could occur at sites of actinic exposure, theorizing that the relative depletion of Langerhan cells caused by sun damage could curtail immune surveillance and lead to this condition. 5 Diagnosis of SCTCL is based on skin microscopy, immunohistochemical staining of T cells in the infiltrate, and the demonstration of T-cell receptor gene rearrangement by polymerase chain reaction analysis. 6 SCTCL is characterized microscopically by lymphocytic infiltration of eccrine glands by T lymphocytes, often associated with eccrine hypertrophy and hyperplasia, and obliteration of the glandular lumen.…”

Section: Discussionmentioning

confidence: 99%

“…Some patients demonstrate lymphocytic infiltration involving both eccrine glands and hair follicles. 5 Reactive mucin deposition can occur in the external root sheath and sebaceous glands with a loss of follicular keratinocytes and alopecia. 7 Epidermotropism and Pautrier's microabscesses, which are typically observed in CTCL, are seen in neither condition, though it could manifest late in the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

A case of syringotropic cutaneous T-cell lymphoma treated with local radiotherapy

Jacob

Scala

Fung

2009

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Combined folliculotropic/syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications

Cited by 21 publications

References 19 publications

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hyperplasia of Hair Follicles and Other Adnexal Structures in Cutaneous Lymphoproliferative Disorders

A case of syringotropic cutaneous T-cell lymphoma treated with local radiotherapy

Contact Info

Product

Resources

About