Combined Exposure to Hypercapnia and Hypoxia Provides Its Maximum Neuroprotective Effect During Focal Ischemic Injury in the Brain

Tregub, Pavel; Kulikov, V. V.; Motin, Yuri; Bespalov, A. G.; Osipov, Ilya

doi:10.1016/j.jstrokecerebrovasdis.2014.09.003

Cited by 27 publications

(14 citation statements)

References 33 publications

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“…If swelling is present, which can dampen vascular flow, the damaging effects on healthy cells may even be more pronounced due to osmotic shock, changes in pH, ionic/amino acid spillage, and CO 2 accumulation (Dreier et al., ; Hartings et al., ). Slight imbalances in ionic state, specifically [K + ] and pH/CO 2 , may contribute to the onset of epilepsy and other neurological diseases (Kaila & Ransom, ; Nedergaard, Kraig, Tanabe, & Pulsinelli, ; Mellergard & Siesjo, ; Mahad, Trapp, & Lassmann, ; Tregub, Kulikov, Motin, Bespalov, & Osipov, ; Andrianopoulos et al., ). In such individuals, additional insults may have an additive or synergistic effect.…”

Section: Discussionmentioning

confidence: 99%

The effects of potassium and muscle homogenate on proprioceptive responses in crayfish and crab

et al. 2017

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Proprioception of limbs and joints is a basic sensory function throughout most of the animal kingdom. It is important to understand how proprioceptive organs and the associated sensory neurons function with altered environments such as increased potassium ion concentrations ([K]) from diseased states, ionic imbalances, and damaged tissues. These factors can drastically alter neuronal activity. To assess this matter, we used the chordotonal organ in a walking leg of a blue crab (Callinectes sapidus) and the muscle receptor organ of the crayfish (Procambarus clarkii). These organs serve as tractable models for the analysis of proprioception. The preparations can help serve as translational models for these effects, which may be observed in other invertebrate species as well as mammalian species (including humans). When extracellular potassium concentration ([K]) is increased to 20 mM in both preparations, mixed results are observed with activity increasing in some preparations and decreasing in others after mechanical displacement. However, when [K] is increased to 40 mM, activity drastically decreases in all preparations. Additionally, proprioceptor sensory activity declines upon exposure to a diluted muscle homogenate, which contains a host of intracellular constituents. The robust effects of altered [K] on proprioception in these models illuminate the potential detriments on neuronal function in cases of severe tissue damage as well as altered [K].

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Section: Discussionmentioning

confidence: 99%

The effects of potassium and muscle homogenate on proprioceptive responses in crayfish and crab

et al. 2017

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“…Several studies suggested that routine oxygen delivery is associated with a small improvement in neurological recovery and a decrease in the frequency of episodes of desaturation (24)(25)(26)(27). On the other hand, recent studies suggested that hypoxia and hypercapnia, or hypercapnia alone, might provide neuroprotective effects (28,29).…”

Section: Shared Pathophysiological Mechanismsmentioning

confidence: 99%

“…It also decreases the number of nocturnal desaturations which may be one of the risk factor for seizures in stroke patients (26,27). But there is also data suggesting that hypoxia and hypercapnia, or hypercapnia alone, provides neuroprotective effects (28,29).…”

Section: Impact Of Copd Treatment On Strokementioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Stroke

Corlăteanu

Covanţev

Mathioudakis

et al. 2018

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world and its incidence and prevalence is on the rise. It is evident that COPD is linked to cardiovascular disease. In the last years, several studies demonstrated that COPD may also be a risk factor for stroke, another major cause of death worldwide. Taking in consideration that COPD has multiple comorbidities it is hard to say whether COPD is an independent risk factor for stroke or it is due to confounding effect. This review is aimed to discuss current data on COPD and stroke, potential links, therapy, and prevention. Current data suggest that COPD may increase the risk of hemorrhagic stroke. The incidence of other stroke subtypes may also be increased in COPD or may be due to confounding effect. However, COPD patients who have stroke are at risk for pulmonary and extrapulmonary complications. We conclude that more studies are needed to further clarify the links between COPD and stroke. The management of COPD as well as the use of prevention therapy is essential to decrease the risk for stroke and should be at special attention in pulmonary medicine and neurology.

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“…[11,12] However, some studies have demonstrated that TJ proteins of cerebral microvessels are down-regulated in response to hypoxia/aglycemia. [13,14] Hypercapnia has been shown to have a signi cant therapeutic effect on brain injury, [15][16][17] and arterial blood CO 2 tension (PaCO 2 ) at 60-100 mmHg had a protective impact on the brain during ischemic injury. [18][19][20] In our previous study, hypercapnia exerted bene cial effects under mild to moderate hypoxemia and augmented the detrimental effects on the brain during severe hypoxemia in a rat model of hypoxiaischemia.…”

mentioning

confidence: 99%

Neuroprotection by hypercapnia in brain ischemic injury followed by persistent hypoxia: an in vivo and in vitro experimental study

Yang¹,

Wang²,

Wu³

et al. 2020

Preprint

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Backgrounds: Therapeutic hypercapnia was shown to have a potential neuroprotective role in our previous studies in a rat model of ischemia followed by hypoxia; however, it is unknown how hypercapnia affects blood-brain barrier (BBB) function under hypoxic conditions in cerebral ischemia. We aimed to observe the BBB permeability changes in response to cerebral ischemia followed by acute hypoxia or hypercapnic hypoxia using in vivo and in vitro models.Methods: Adult rats underwent unilateral common carotid artery ligation, at 60 min of ligation, they were exposed to systemic hypoxia with ventilation of 15% oxygen (O2) combined with 8% carbon dioxide (CO2) for 180 min. Cerebral blood flow, BBB integrity, infarct volume and behavior were assessed in this study. In vitro, rat brain microvascular endothelial cells (BMECs) were isolated and cultured under O2 (1% or 21%) with or without 15% CO2 for 6 h. Cell viability and transendothelial electrical resistance (TEER) were measured. The ZO-1 and occludin protein levels were explored in BMECs by Western blotting.Results: Arterial blood O2 (PaO2) tensions averaged 56.1 mmHg during simple hypoxia, and arterial blood CO2 tensions (PaCO2) were maintained at normal values or 60–80 mmHg. Hypercapnia treatment significantly reduced brain infarct volume and pathophysiological changes in hypoxic ischemia rats. Furthermore, in the in vitro experiment, hypercapnia significantly improved the growth condition of BMECs, reduced endothelial cell permeability and attenuated the loss of ZO-1 and occludin protein in BMECs induced by hypoxia. Conclusions: Hypercapnia exerts beneficial effects on the BBB permeability in the rat model of hypoxic-ischemic injury and recovers the neurologic status especially within one week, possibly by preventing the loss of tight junction proteins.

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Combined Exposure to Hypercapnia and Hypoxia Provides Its Maximum Neuroprotective Effect During Focal Ischemic Injury in the Brain

Cited by 27 publications

References 33 publications

The effects of potassium and muscle homogenate on proprioceptive responses in crayfish and crab

The effects of potassium and muscle homogenate on proprioceptive responses in crayfish and crab

Chronic Obstructive Pulmonary Disease and Stroke

Neuroprotection by hypercapnia in brain ischemic injury followed by persistent hypoxia: an in vivo and in vitro experimental study

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