Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention

Yoshihara, Fumiki; Hosoda, Hiroshi; Doi, Takahito; Yoshida, Morikatsu; Kïtamura, Kazuo; Yamamoto, Haruko; Asaumi, Yasuhide; Ishibashi‐Ueda, Hatsue; Kishida, Masatsugu; Arisato, Tetsuya; Matsuo, Miki; Miyazato, Minoru; Yasuda, Satoshi

doi:10.1007/s10157-021-02113-9

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Statistical analyses defined high urinary L-FABP in the T12 sample as a predictor and the T72 sample as a significant discriminator for AKI cases. The obtained data are in hand with the previously reported significant differences between levels of urinary L-FABP estimated at 24 and 48-h after dye injection before cardiac surgery [ 37 ] and with the conclusion that estimation of urinary L-FABP levels improves early prediction of AKI in patients hospitalized at medical cardiac intensive care units [ 38 ] and after coronary angiography/PCI [ 39 ]. Also, these results are in line with the survey study that found cardiologists who introduced pre- and peri-cardiac interventions estimation of L-FABP into patient care were 2.9 times more likely to correctly identify their patients' risk for AKI and were more than twice as likely to treat AKI [ 40 ].…”

Section: Discussionsupporting

confidence: 74%

Biomarker array for prediction of acute kidney injury after percutaneous coronary intervention for patients who had acute ST segment elevation myocardial infarction

Alkassas,

Elbarbary,

Sherif

et al. 2023

Heart Vessels

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Acute kidney injury (AKI) is a common complication after Percutaneous Coronary Intervention (PCI) for ST segment elevation myocardial infarction (STEMI) and is associated with poor outcomes. AKI is diagnosed by the dynamic change of serum Cr, but it could not predict AKI. This study aimed to evaluate a biomarker array that may fulfill this shortage. Setting: Cardiology Department, Tanta University Hospital. Design: Prospective interventional study included 280 acute STEMI patients who underwent emergency PCI. Serial samples of blood and urine were obtained at the time of admission to the hospital (T0) and PCI unit (T1) and at 12 h and 72 h (T12 and T72) after coronary revascularization to estimate levels of serum Cr, creatine phosphokinase, and heart-type fatty acid-binding protein (H-FABP) and calculation of neutrophil/lymphocyte ratio (NLR) and urinary liver-type FABP (L-FABP). AKI was diagnosed according to the recommendations of the European Renal Best Practice as the times of increased serum Cr concerning baseline level. 85 patients developed AKI. Regression analyses defined a high NLR ratio in the T0 sample as the most significant predictor for early AKI diagnosed at T1 time, while high NLR and serum H-FABP levels in T1 samples as the significant predictors for AKI defined at T12 time. However, high urinary L-FABP levels in T12 samples and high NLR are significant predictors for AKI at T72 time. Combined estimations of serum H-FABP and urinary L-FABP with the calculation of NLR could predict the oncoming AKI and discriminate its pathogenesis. The study protocol was approved by the Local Ethical Committee at Tanta Faculty of Medicine by approval number: 35327/3/22. For blindness purposes, the authors will be blinded about the laboratory results till the end of 72 h after revascularization and the clinical pathologist will be blinded about the indication for the requested investigations.

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Section: Discussionsupporting

confidence: 74%

Biomarker array for prediction of acute kidney injury after percutaneous coronary intervention for patients who had acute ST segment elevation myocardial infarction

Alkassas,

Elbarbary,

Sherif

et al. 2023

Heart Vessels

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“…Guo et al found that within 24 h after PCI, elevated serum creatinine was usually strongly associated with postoperative mortality [ 19 ]. Fumiki found that the urinary liver-type fatty acid-binding protein/creatinine ratio could be a predictor and was related to worsening renal function in patients undergoing elective PCI [ 20 ]. What is more, the research showed that in patients with normal BMI undergoing PCI, low serum creatinine was associated with higher overall mortality and cardiovascular mortality [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatinine Levels on All-Cause Mortality

Yang,

Zhang,

Ding

et al. 2024

Med Sci Monit

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Background The correlation between serum creatinine levels and the long-term prognosis of patients undergoing percutaneous coronary intervention (PCI) has not yet been systematically investigated. This study aimed to evaluate the association between long-term prognosis and serum creatinine levels in patients after PCI. Material/Methods This was an observational cohort study of 2533 patients who received PCI and completed serum creatinine and other tests in China. The study’s primary prognostic indicators were the frequency of clinical adverse events, all-cause death, cardiac death, acute myocardial infarction, and stroke. All-cause death referred to death from all causes during the follow-up period, whereas cardiac death was death due to cardiac injury resulting in severe cardiac dysfunction or failure. Clinical events included death, ischemia, and stroke. Yao et al completed the entire study and uploaded the data to the DATADRYAD website. We used only this data for secondary analysis. Results The study involved 2533 participants, with a mean age of 59.9±11.1 years and a median follow-up of 29.8 months. The analysis, controlling for confounding factors, revealed a positive correlation between serum creatinine and all-cause death (OR: 2.178, 95% CI: 1.317–3.603, P <0.05), which was confirmed by the results of sensitivity analysis ( P for trend <0.05). However, no direct linear correlation was found between serum creatinine and acute myocardial infarction, cardiac death, or stroke. Conclusions There was a linear correlation between serum creatinine and all-cause death in the long-term prognosis of patients after PCI, independent of acute myocardial infarction, cardiac death, and stroke.

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Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention

Cited by 2 publications

References 36 publications

Biomarker array for prediction of acute kidney injury after percutaneous coronary intervention for patients who had acute ST segment elevation myocardial infarction

Biomarker array for prediction of acute kidney injury after percutaneous coronary intervention for patients who had acute ST segment elevation myocardial infarction

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatinine Levels on All-Cause Mortality

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