Combined endothelial and epithelial barrier disruption of the colon may be a contributing factor to the Ebola sepsis-like syndrome

Lynn, Lawrence A.

doi:10.1186/s13037-014-0048-z

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…Recently, intramedullary nailing has been considered the gold standard for the treatment of tibial shaft fractures [2], because it can provide good fracture reduction and early weight-bearing exercise. More importantly, intramedullary nail involves minimal surgical injury for preservation of blood supply to the fracture [3]. However, there are some disadvantages in traditional intramedullary nailing.…”

Section: Introductionmentioning

confidence: 99%

“…It carries no risk of damaging the patellar tendon and infrapatellar nerve, so it may reduce the rate of anterior knee pain [5]. This method helps to reduce varus and valgus deformities because the semi extended position may eliminate the extension force of the quadriceps [3]. The suprapatellar approach is controversial for it may lead to injury to the joint involvement and the cartilage.…”

Section: Introductionmentioning

confidence: 99%

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A meta-analysis of suprapatellar versus infrapatellar intramedullary nailing for the treatment of tibial shaft fractures

Xu¹,

Fu-shun

Xin

et al. 2019

Heliyon

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BackgroundWhether the optimal treatment for tibial shaft fractures is suprapatellar intramedullary nailing or infrapatellar approach is controversial.Materials and methodsPubMed, Embase, Cochrane, Web of science and CNKI, Wan fang Chinese databases were retrieved from their establishment to April 26, 2017. Seven studies (three randomized and four clinical controlled trials) were included in the final analysis. This meta-analysis included 683 patients with tibial shaft fracture (suprapatellar: 341; infrapatellar: 342).ResultsThere was significant difference between suprapatellar and infrapatellar approach surgery in the incidence of knee pain (P = 0.003). The malalignment of the sagittal and coronal plane in suprapatellar surgery was more serious than in the infrapatellar approach (sagittal plane: P < 0.00001; coronal plane:P = 0.07). The infrapatellar approach surgery was more time-consuming than suprapatellar surgery (P = 0.01), with no significant difference in knee function score (P = 0.35).ConclusionsSuprapatellar intramedullary nailing reduced the incidence of knee pain and the average malalignment of fractures compared to infrapatellar intramedullary nailing. It also reduced the operation time and fluoroscopy time. The results of the study should be interpreted with caution due to the heterogeneity of the study designs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A meta-analysis of suprapatellar versus infrapatellar intramedullary nailing for the treatment of tibial shaft fractures

Xu¹,

Fu-shun

Xin

et al. 2019

Heliyon

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“…11–13 Furthermore, the application of this approach increases patients’ confidence in the final decision and enhances both patient and physician comfort in proceeding with surgery involving potential risks. 14, 15 Thus, patient concerns, preferences, and the perceived impact of treatment on quality of life must be considered when discussing treatment options to improve patient satisfaction with the shared treatment decision.…”

Section: Introductionmentioning

confidence: 99%

Multifactor Influences of Shared Decision-Making in Acoustic Neuroma Treatment

Nellis

Sharon

Pross

et al. 2017

Otology &Amp; Neurotology

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Objective To identify factors associated with treatment modality selection in acoustic neuromas. Study Design Prospective observational study Setting Tertiary care neurotology clinic Patients Data was prospectively collected from patients initially presenting to a tertiary care neurotology clinic between 2013 and 2016. Patients who did not have MRI, demographic, psychometric, or audiometric data were excluded from analysis. Intervention Demographic information, clinical symptoms, tumor characteristics, and psychometric data were collected to determine factors associated with undergoing acoustic neuroma surgical resection using univariate and multiple logistic regression analysis. Main Outcome Measure The decision to pursue acoustic neuroma surgical resection versus active surveillance. Results A total of 216 patients with acoustic neuroma (mean age 55 years, 58% female) were included. 98 patients (45.4%) pursued surgical resection, 118 patients (54.6%) pursued active surveillance. Surgical treatment was significantly associated with patient age < 65, higher grade tumors, growing tumors, larger volume tumors, lower word discrimination scores, Class D hearing, headache and vertigo as presenting symptoms, higher number of total symptoms, and higher headache severity scores (p<0.05). There was no significant association between surgical intervention and preoperative quality of life, depression, and self-esteem scores. On multiple logistic regression analysis, the likelihood of undergoing surgical resection significantly decreased for patients older than age 65 (OR 0.19; 0.05-0.69) and increased in patients with medium (OR 4.34; 1.36-13.81), moderately large (OR 33.47; 5.72-195.83), large grade tumors (OR 56.63; 4.02-518.93), tumor growth present (OR 4.51; 1.66-12.28), Class D hearing (OR 3.96; 1.29-12.16), and higher headache severity scores (OR 1.03;95% CI 1.01-1.05). The likelihood of undergoing surgical resection was completely predictive for giant grade tumors and not significant for small grade tumors and Class B or C hearing. Conclusions Non-elderly acoustic neuroma patients with larger tumors, growing tumors, significant hearing loss, and worse headaches are more likely to pursue surgical resection rather than active surveillance. Psychological factors such as quality of life, depression, and self-esteem do not seem to influence decision-making in this patient population.

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“…However, no signs of cardiogenic shock, severe chemical transaminitis corresponding to hepatic ischemia or necrosis, or severe hemolysis were observed at 5 dpi in EBOV Kikwit–infected NHPs or at 7 dpi in EBOV Makona–infected NHPs. One possibility is that the NHPs were experiencing either intestinal and/or mesenteric ischemia or necrosis, conditions that have been seen in other viral infections ( 39 , 40 ) and which may, as postulated by Lynn ( 41 ), precipitate late Ebola sepsis-like syndrome.…”

Section: Discussionmentioning

confidence: 99%

Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates

Reisler¹,

Yu²,

D’Onofrio³

et al. 2017

Emerg. Infect. Dis.

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The Ebola virus (EBOV) outbreak in West Africa during 2013–2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.

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Combined endothelial and epithelial barrier disruption of the colon may be a contributing factor to the Ebola sepsis-like syndrome

Cited by 7 publications

References 5 publications

A meta-analysis of suprapatellar versus infrapatellar intramedullary nailing for the treatment of tibial shaft fractures

A meta-analysis of suprapatellar versus infrapatellar intramedullary nailing for the treatment of tibial shaft fractures

Multifactor Influences of Shared Decision-Making in Acoustic Neuroma Treatment

Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates

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