Combined efficacy of Vigna radiata (L.) R. Wilczek and Amorphophallus paeoniifolius (Dennst.) Nicolson on serum lipids in albino rats

Abstract

Coronary Artery Disease (CAD) is a major killer disease throughout the world. Dyslipidemia is a major contributor to the risk of CAD. Several dietary articles traditionally used in India and other South Asian countries reduced dyslipidemia. The present study was undertaken to evaluate the combined effect of Mung bean () and Elephant foot yam () on serum lipids and atherogenic indices in albino rats and to compare it with a standard drug Cholestyramine. Thirty healthy albino rats of both sexes (150-200 g) were randomized to 5 groups of 6 animals each. The grouping were done based on the following criteria: Group I: Normal Control Group, Group II: (Standard Group): Cholestyramine resin 5 mg/kg bw, Group III: (Half Dose Group): Drug powder at 540 mg/kg bw, Group IV: (Effective Dose Group): Drug powder at 1080 mg/kg bw, and Group V: (Double Dose Group): Drug powder at 2160 mg/kg bw. Lipid profile was estimated at the beginning and after 30 days of treatment. The Effective and Double doses of the drug reduced Total cholesterol along with levels of Triglycerides, Low density lipoprotein and Very low density lipoprotein levels significantly (p < 0.01) along with a significant (p < 0.01) increase in high density lipoproteins (HDL) in rats. There was also significant (p < 0.01) improvement in atherogenic indices like Castelli Risk Index I, Non HDL C/HDL, Castelli risk Index II, TG/HDL, Atherogenic coefficient and Atherogenic Index of Plasma. The combination of powdered sprouted mung bean and yam powder have excellent lipid lowering potential.

Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

“…of this mixture was administered to albino mice models, which was caused by lowering the hormone leptin levels. The hypolipidemic activity of A. paeoniifolius glucomannan was comparable to that of statins, involving the competitive inhibition of HMG-CoA reductase and reduced LDL production [96]. In another study, Safitri et al [97] demonstrated that Porang glucomannan administered at doses between 25 and 100 mg/200 g b.w.…”

Scientometric Study on Dyslipidaemia

“…The combination of powdered sprouted mung bean (green gram ) and yam powder (Amorphophallus paeoniifolius) have significantly reduced the serum lipid levels as well as the atherogenic indices in albino rats in comparison to the, bile acid sequestering agent, Cholestyramine as standard. Thus use of this combination could help in reducing high CAD risk among Asians [22].…”