Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

Østergaard, Jane Nautrup; Grønbæk, Morten; Schnohr, Peter; Sørensen, Thorkild I A; Heitmann, Berit Lilienthal

doi:10.1038/ijo.2009.274

Cited by 28 publications

(13 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent data suggest that LBM, similar to proposed effects of fat mass in breast cancer progression, may exert a powerful endocrine, immune and hormonal influence within the body (38). Of note, the association of weight loss with increased mortality has also been reported in several recent observational studies that have not been restricted to only breast cancer survivors (39–42). …”

Section: Discussionsupporting

confidence: 58%

Weight Change and Survival after Breast Cancer in the After Breast Cancer Pooling Project

Caan

Kwan

Shu

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

115

155

View full text Add to dashboard Cite

Background Weight change after a breast cancer diagnosis has been linked to lower survival. To further understand effects of post-diagnostic weight variation on survival, we examined the relationship by comorbid status and initial BMI. Methods The current analysis included 12,915 breast cancer patients diagnosed between 1990 and 2006 with Stage I–III tumors from four prospective cohorts in the US and China Hazard ratios (HR) and 95% confidence intervals (CI) representing the associations of five weight change categories (within <5% [reference]; 5–<10% and ≥10% loss and gain) with mortality were estimated using Cox proportional hazards models. Results Mean weight change was 1.6 kg. 14.7% of women lost and 34.7% gained weight. Weight stability in the early years post-diagnosis was associated with the lowest overall mortality risk. Weight loss ≥10% was related to a 40% increased risk of death (HR=1.41; 95% CI: 1.14, 1.75) in the US and over three times the risk of death (HR=3.25; 95% CI: 2.24, 4.73) in Shanghai. This association varied by pre-diagnosis BMI, and in the US lower survival were seen for women who lost weight and had comorbid conditions. Weight gain ≥10% was associated with a non-significant increased risk of death. Conclusions Prevention of excessive weight gain is a valid public health goal for breast cancer survivors. Although intentionality of weight loss could not be determined, women with comorbid conditions may be particularly at risk of weight loss and mortality. Impact Weight control strategies for breast cancer survivors should be personalized to the individual’s medical history.

show abstract

Section: Discussionsupporting

confidence: 58%

Weight Change and Survival after Breast Cancer in the After Breast Cancer Pooling Project

Caan

Kwan

Shu

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

115

155

View full text Add to dashboard Cite

show abstract

“…It was shown that overweight adults who lost weight over 9 years had more favorable (lower) total and LDL cholesterol levels compared to normal-weight control, but less favorable BG levels [32]. In other studies weight loss was associated with excess mortality when compared with weight stability, even when controlled for confounding due to diseases known to cause both weight loss and increased mortality [33, 34]. …”

Section: Discussionmentioning

confidence: 99%

Dynamic Determinants of Longevity and Exceptional Health

Yashin

Arbeev

Akushevich

et al. 2010

Current Gerontology and Geriatrics Research

View full text Add to dashboard Cite

It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of age trajectories of the physiological indices could also be important contributors to morbidity and mortality risks. In this paper we use data on longitudinal changes in body mass index, diastolic blood pressure, pulse pressure, pulse rate, blood glucose, hematocrit, and serum cholesterol in the Framingham Heart Study participants, to investigate this possibility in depth. We found that some of the variables describing individual dynamics of the age-associated changes in physiological indices influence human longevity and exceptional health more substantially than the variables describing physiological state. These newly identified variables are promising targets for prevention aiming to postpone onsets of common elderly diseases and increase longevity.

show abstract

“…The question whether loss of FM or FFM in older persons increases the risk of mortality is important in order to target therapeutic strategies. The loss of FM can theoretically be prevented by hypercaloric diets, while the loss of FFM can be limited by appropriate calorie and protein intakes (23) and the addition of physical activity (13,24). Furthermore, if the loss of both FM and FFM increases the risk of mortality in older persons, it would suggest that any hypocaloric diet, even voluntary, should be avoided in these persons.…”

Section: Introductionmentioning

confidence: 99%

Impact of body composition changes on risk of all-cause mortality in older adults

Herrmann

Spoerri

et al. 2016

Clinical Nutrition

View full text Add to dashboard Cite

show abstract

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

Abstract: Objective: To estimate the excess deaths associated with weight loss in combination with leisure time physical activity among overweight or obese people. Design: Prospective cohort study.

Cited by 28 publications

References 60 publications

Weight Change and Survival after Breast Cancer in the After Breast Cancer Pooling Project

Weight Change and Survival after Breast Cancer in the After Breast Cancer Pooling Project

Dynamic Determinants of Longevity and Exceptional Health

Impact of body composition changes on risk of all-cause mortality in older adults

Contact Info

Product

Resources

About