Combined effects of thermal stress and Cd on lysosomal biomarkers and transcription of genes encoding lysosomal enzymes and HSP70 in mussels, Mytilus galloprovincialis

The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants

“…Temperature stress has been associated with elevated ROS production and oxidative damage in other bivalves (Abele et al, 2002;Heise et al, 2003;Verlecar et al, 2007) including U. tumidus (Falfushynska et al, 2014b,a). Elevated ambient temperatures can also increase sensitivity of bivalves to the pollutants' toxicity by enhancing the oxidative injury (Lannig et al, 2006;Sokolova and Lannig, 2008;Katsikatsou et al, 2011;Ivanina et al, 2012), causing elevated levels of DNA strand breaks (Gagné et al, 2007), and exacerbating the negative effects of pollutants on lysosomal membrane stability and gene transcription (Negri et al, 2013;Izagirre et al, 2014).…”

Lysosomal responses to heat-shock of seasonal temperature extremes in Cd-exposed mussels

“…Likewise, mussels respond to pollution and other environmental stress sources in a way that can be measured through biological effect biomarkers; that is why they are widely used as sentinels in coastal ecosystem health assessment (UNEP/RAMOGE, 1999;ICES, 2012;Marigómez et al, 2013a). Besides, recent investigations have reported interactive effects of either elevated temperature or heat-shock with pollution (Sokolova, 2004;Baines et al, 2006;Lannig et al, 2006a,b;Sokolova and Lannig, 2008;Ivanina et al, 2009;Negri et al, 2013;Izagirre et al, 2014;Múgica et al, 2015).…”

“…Also, lysosomes play a key role in defence against oxidative stress (Moore et al, 2006), which is known to be induced during extreme thermal exposure (Abele et al, 1998). Both pollutant exposure (Lowe et al, 1981;Marigómez et al, 2005aMarigómez et al, ,b, 2006Marigómez et al, , 2013bMarigómez and Baybay-Villacorta 2003;Moore et al, 2007;Izagirre and Marigómez, 2009;Izagirre et al, 2014) and changes in natural factors such as, e.g., temperature (Moore 1976;Stickle et al, 1985;Abele et al, 1998;Tremblay et al, 1998;Izagirre et al, 2008Izagirre et al, , 2014Izagirre and Marigómez, 2009) elicit lysosomal enlargement and membrane destabilisation in mussel digestive cells. Interestingly, lysosomal responses to gradual temperature elevation have been reported to be seasondependent in mussels (Múgica et al, 2015).…”

“…respond against thermal stress . Within this context, the interactive effects of pollutants and elevated temperatures in aquatic ectotherms have been increasingly investigated during the last years (Piano et al, 2004;Sokolova, 2004;Hallare et al, 2005;Cherkasov et al, 2006;Lannig et al, 2006;Ivanina et al, 2009;Micovic et al, 2009;Negri et al, 2013;Izagirre et al, 2014). However, though the relevance of extreme temperature events is gaining recognition, the majority of the studies on the interactions between thermal stress and pollution deal with the consequences of either gradual temperature elevation or acclimatisation to high temperatures at mid-and long-term.…”

“…Global warming in a multiple stress scenario may pose a surplus threat for marine organisms inhabiting polluted areas because the susceptibility to pollutants can be strongly modified by SST and, vice versa, as the thermal stress window can be modified by the presence of pollutants (Lannig et al, 2006;Sokolova and Lannig, 2008;Sokolova et al, 2012;Izagirre et al, 2014). Higher temperatures may result in higher solubility of metal compounds, thus making them more bioavailable (Wang et al, 2005;Mubiana and Blust, 2006).…”