Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, Devasena; Müller, David C.; Λάγιου, Παγώνα; Ahrens, Wolfgang; Holcátová, Ivana; Merletti, Franco; Kjærheim, Kristina; Polesel, Jerry; Simonato, Lorenzo; Canova, Cristina; Castellsagué, Xavier; Macfarlane, Tatiana V.; Znaor, Ariana; Thomson, Peter; Robinson, Max; Conway, David I.; Healy, Claire M.; Tjønneland, Anne; Westin, Ulla; Ekström, Johanna; Chang‐Claude, Jenny; Kaaks, Rudolf; Overvad, Kim; Drogan, Dagmar; Hallmans, Göran; Laurell, Göran; Bueno-De-Mesquita, H. Bas; Peeters, Petra H.M.; Agudo, Antonio; Larrañaga, Nerea; Travis, Ruth C.; Palli, Domenico; Barricarte, Aurelio; Trichopoulou, Antonia; George, Saitakis; Trichopoulos, Dimitrios; Quiŕos, J. Ramón; Grioni, Sara; Sacerdote, Carlotta; Navarro, Carmen; Sánchez, María José; Tumino, Rosario; Severi, Gianluca; Boutron-Ruault, Marie Christine; Clavel‐Chapelon, Françoise; Panico, Salvatore; Weiderpass, Elisabete; Lund, Eiliv; Gram, Inger Torhild; Riboli, Elio; Pawlita, Michael; Waterboer, Tim; Kreimer, Aimée R.; Johansson, Mattias

doi:10.1093/ije/dyw069

Cited by 73 publications

(70 citation statements)

References 27 publications

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“…Recent studies support the view that HPV and smoking act as independent risk factors for oropharyngeal cancer. It has also been shown that the prevalence of oropharyngeal cancer increases with smoking for both HPV‐16‐positive and HPV‐16‐negative persons .…”

Section: Oral Squamous Cell Carcinomamentioning

confidence: 99%

Oral manifestations of human papillomavirus infections

Syrjänen

2018

European J Oral Sciences

109

120

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Papillomaviruses are one of the oldest viruses known, dating back 330 million years. During this long evolution, human papillomaviruses (HPV) have developed into hijackers of human cellular and immune systems in which they replicate and remain silent. Systematic studies on oral HPV infections and their outcomes are still scarce. Oral HPV infections have been linked to sexual behaviour, but recent evidence supports their horizontal, mouth‐to‐mouth, transmission. Most HPV infections in infants are acquired vertically from the mother during the intrauterine period, during delivery, or later via saliva. The best‐known benign clinical manifestations of HPV infection are oral papilloma/condyloma and focal epithelial hyperplasia. Evidence is emerging which suggests that some oral HPV infections might persist. Persistent HPV infection is mandatory for HPV‐associated malignant transformation. However, progression of HPV‐induced lesions to malignancy requires additional cofactors. In the early 1980s, we provided the first evidence that a subset of oral cancers and other head and neck cancers might be causally linked to HPV infection. This review summarizes current knowledge on the virus itself, its transmission modes, as well as the full spectrum of oral HPV infections – from asymptomatic infections to benign, potentially malignant oral lesions, and squamous cell carcinoma.

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Section: Oral Squamous Cell Carcinomamentioning

confidence: 99%

Oral manifestations of human papillomavirus infections

Syrjänen

2018

European J Oral Sciences

109

120

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“…In the same study, the combined effect of heavy smoking and alcohol consumption with HPV16 infection increased the OPSCC risk further (OR = 48.76; 95% CI 15.83–150.17 and OR = 50.60; 95% CI 15.96–160.40, respectively) [68]. Smoking is also consistently associated with an increased risk of OPSCC in models stratified by HPV16 seropositivity [69]. …”

Section: Risk Factors Of Hpv-associated Hnsccmentioning

confidence: 99%

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

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Background: The association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSCC) was first described in 1982–1983 by the authors of this review. Prompted by this discovery 35 years ago, an entirely new field of HPV research has emerged, resulting in a paradigm shift from smoking and alcohol as the only etiological factors to confirmation of HNSCC as an important group of HPV-related human malignancies. Summary: In this review, the authors first describe the scope (i.e., HNSCC) by the anatomic sites of the tumors. Their important site-specific differences in epidemiology are emphasized, and the misconceptions caused by the adopted practice of pooling all tumors from these divergent anatomic sites as a single entity (HNSCC) are pinpointed. The convincing evidence of the established risk factors (smoking and alcohol) is briefly addressed, before entering in the discussion on the causal role of HPV in HNSCC pathogenesis. The global HPV prevalence in different subsets of HNSCC is summarized using the data extracted from all meta-analyses published since 2010. Of all HNSCC subsets, oropharyngeal SCC has an HPV profile distinct form all the other subsets, and the possible mechanisms explaining this intimate association with HPV are discussed. Key Messages: Recent global trends show a constant increase in HNSCC rates particularly among younger age groups. The evidence on cigarette smoking and alcohol consumption as the prime risk factors of HNSCC is overwhelming. During the past 35 years, however, increasing evidence has accumulated implicating an important causal role of HPV in HNSCC. These data have important clinical implications, HPV detection and tailored treatment strategies for HPV-positive HNSCCs currently being an integral part of the oncological management practices of HNSCC.

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“…Conversely, non‐oropharyngeal HNC, malignancies arising in the oral cavity, hypopharynx, and larynx, are typically HPV‐negative and associated with heavy smoking, alcohol use, and poor oral hygiene but not with sexual behavior . Recent evidence does, however, support complex interactions between the effects of HPV, alcohol, and tobacco exposure in modifying the risk of OPC …”

Section: Introductionmentioning

confidence: 99%

Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

Faraji

Eisele

Fakhry

2017

Laryngoscope Investig Oto

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ObjectiveTo review recent literature on human papillomavirus‐related (HPV‐positive) oropharyngeal squamous cell carcinoma (OPC) and focus on implications of recurrent and metastatic disease.MethodsPrimary articles from 1990 to 2016 indexed in MEDLINE (1) pertaining to the epidemiology of HPV‐positive OPC and (2) providing clinical insight into recurrent and metastatic OPC.ResultsThe incidence of HPV‐positive OPC is increasing globally. HPV‐positive OPC is a subtype with distinct molecular and clinical features including enhanced treatment response and improved overall survival. While disease recurrence is less common in patients with HPV‐positive OPC, up to 36% of patients experience treatment failure within eight years. Recurrent and metastatic OPC has historically signified poor prognosis, however recent data are challenging this dogma. Here, we discuss recurrent and metastatic OPC in the context of HPV tumor status.ConclusionHPV‐positive OPC exhibits distinct genetic, cellular, epidemiological, and clinical features from HPV‐negative OPC. HPV tumor status is emerging as a marker indicative of improved prognosis after disease progression in both locoregionally recurrent and distant metastatic OPC.Level of EvidenceN/A.

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Combined effects of smoking and HPV16 in oropharyngeal cancer

Cited by 73 publications

References 27 publications

Oral manifestations of human papillomavirus infections

Oral manifestations of human papillomavirus infections

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

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