Combined effects of sex hormone‐binding globulin and sex hormones on risk of incident type 2 diabetes

Hu, Jinbo; Zhang, Aiping; Wang, Yue; Goswami, Richa; Huang, Zhou; Zhang, Yi; Wang, Zhihong; Li, Rong; Cheng, Qingfeng; Zhen, Qianna; Li, Qifu

doi:10.1111/1753-0407.12322

Cited by 34 publications

(27 citation statements)

References 32 publications

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“…A significant correlation (r ¼ 0.971) was confirmed between the BPA values measured by the ELISA and the high-performance liquid chromatography [31]. In recent years, commercially available ELISA kits were well designed for the determination of human serum BPA concentration, and were widely used in epidemiological studies [12,17]. The kidneys are the major organs for the excretion of BPA, and renal excretion of BPA is dependent on GFR, renal tubular secretion, and reabsorption [12].…”

Section: Discussionmentioning

confidence: 91%

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Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension

Wang

Xiang

et al. 2016

Journal of Hypertension

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Section: Discussionmentioning

confidence: 91%

“…This was a prospective observational study conducted on patients attending the Environment, Inflammation, and Metabolic Diseases Study (EIMDS) [16,17]. The EIMDS aimed at evaluating the influence of environmental and inflammatory factors on metabolic diseases such as obesity, type 2 diabetes, hypertension, and CKD.…”

Section: Study Populationmentioning

confidence: 99%

Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension

Wang

Xiang

et al. 2016

Journal of Hypertension

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“…In men with obesity, metabolic syndrome and DM2, the activity of the male HPG axis and the T production are decreased, which lead to androgen deficiency [95][96][97]. Along with this, in diabetic men the plasma level of estrogens and the ratio of estrogen/T are significantly increased, which due to the increased activity of aromatase and the altered production of sex hormone-binding globulin [98][99][100][101]. The elevated concentrations of reactive oxygen species and inflammatory factors lead to the damage in Leydig cells and reduce their steroidogenic activity [97,102].…”

Section: Leptin Regulation Of the Male Gonadal Axis And Steroidogenesmentioning

confidence: 99%

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

Шпаков¹,

Ryzhov²,

Bakhtyukov³

et al. 2018

Advances in Testosterone Action

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There is evidence that the mass and metabolic status of the adipose tissue that produces adipokines significantly affect the activity of the hypothalamic-pituitary-gonadal (HPG) axis and the synthesis of testosterone. This is due to the fact that adipokines, such as leptin, adiponectin, visfatin and resistin have an important role in the regulation of the male HPG axis and steroidogenesis in the testes. The regulation of the HPG axis by adipokines can be carried out both through the changes the plasma levels of adipokines (a systemic regulation) and through the changes in the expression and activity of adipokines in the pituitary and testes, the components of the HPG axis (an autonomous regulation). This review presents the comprehensive analysis of the involvement of leptin, adiponectin, resistin and visfatin in the regulation of the male HPG axis and the testosterone production, as well as of the possible mechanisms of this regulation. The role of adipokines in the dysregulation of the male reproductive system and the impaired steroidogenic activity in the testes in obesity and type 2 diabetes mellitus are also discussed.

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“…The EIMDS aimed at evaluating the influence of environmental and inflammatory factors on metabolic diseases such as obesity, type 2 diabetes, hypertension and chronic kidney disease [9,10]. Essential hypertension was defined as an average blood pressure ≥140/90 mmHg on at least two different occasions, without any evidence of secondary hypertension.…”

Section: Patientsmentioning

confidence: 99%

Association Between Serum Cortisol and Chronic Kidney Disease in Patients with Essential Hypertension

Xiang²,

Hu³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Serum cortisol level is elevated in patients with essential hypertension. We aimed at investigating the association of serum cortisol levels with parameters of renal function in essential hypertension. Methods: One hundred and seventy-eight patients with essential hypertension participated in the study. Fasting serum samples were collected at 8:00 am. Renal function was measured as estimated glomerular filtration rate (eGFR) calculated by the Chronic Kidney Disease Epidemiology Collaboration creatinine- cystatin C equation (eGFRcr-cys). Correlation analysis and stepwise regression analysis were used to detect the relationship between cortisol and eGFRcr-cys. The distributions of serum cortisol were split by the tertiles and subjects were stratified into those with low, median and high levels accordingly. Results: Serum cortisol levels were significantly higher in subjects whose eGFRcr-cys<90 ml/min/1.73 m² than subjects whose eGFRcr-cys>90 ml/min/1.73 m² (394.0±93.4 vs. 343.2±98.4 nmol/L, P=0.001). Age, systolic blood pressure, and serum total cholesterol, uric acid, cortisol levels were significantly associated with eGFRcr-cys, serum levels of creatinine and cystatin C. After adjusting for clinical factors, serum cortisol level had a statistically significant negative association with the eGFRcr-cys (β=-0.19, P=0.027), and positive associations with cystatin C (β=0.31, P=0.001) and creatinine (β=0.14, P=0.044). With the increment of cortisol tertile, the eGFRcr-cys significantly decreased (93.18±14.36 vs. 84.61±14.67 vs. 81.29±12.36 ml/min/1.73 m² for low, median and high tertile, respecively, P=0.001). Conclusion: Serum cortisol level was negatively correlated with eGFRcr-cys in subjects with essential hypertension. Further studies are needed to investigate whether cortisol plays a role in hypertensive nephropathy development.

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Combined effects of sex hormone‐binding globulin and sex hormones on risk of incident type 2 diabetes

Abstract: Low SHBG in conjunction with high estradiol has an additive detrimental effect on the risk of T2D in men.

Cited by 34 publications

References 32 publications

Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension

Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

Association Between Serum Cortisol and Chronic Kidney Disease in Patients with Essential Hypertension

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