2008
DOI: 10.1016/j.bone.2008.07.251
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Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1–34) in metaphyseal bone healing

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Cited by 49 publications
(31 citation statements)
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“…Some studies have delivered PTH with cells, including periodontal ligament cells (Wolf et al, 2012), BMSCs (Pettway et al, 2005) and MSCs (Yu et al, 2012b). Together, these studies have demonstrated increased bone formation between 1.3 (Morgan et al, 2008) and 4.1 fold (Kempen et al, 2010) in small animals following dosages from 10 to 90 μg/ kg/day. One large animal study demonstrated between 2 and 4 fold following dosages of 0.015 µmol/kg (Delmas et al, 1995).…”
Section: Direct Administration Of Pthmentioning
confidence: 96%
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“…Some studies have delivered PTH with cells, including periodontal ligament cells (Wolf et al, 2012), BMSCs (Pettway et al, 2005) and MSCs (Yu et al, 2012b). Together, these studies have demonstrated increased bone formation between 1.3 (Morgan et al, 2008) and 4.1 fold (Kempen et al, 2010) in small animals following dosages from 10 to 90 μg/ kg/day. One large animal study demonstrated between 2 and 4 fold following dosages of 0.015 µmol/kg (Delmas et al, 1995).…”
Section: Direct Administration Of Pthmentioning
confidence: 96%
“…Alternatively, combinations with VEGF or TGF-β3 (Ripamonti et al, 2010) constitute mutualistic approaches where the angiogenic factor induces vessel ingrowth into the defect (2 fold (Zhang et al, 2010a)), the chondrogenic factor induces cartilaginous matrix production to fill the defect void, and the osteogenic factor induces resultant callus mineralisation and eventual bone formation (three lineages important for recapitulation of the in vivo bone healing cascade). Other factors and compounds used in combination with BMP-7 include BBP , FGF-2 , insulin-like growth factor 1 (IGF-1) , pamidronate (Yu et al, 2010a), PDGF (Zhang et al, 2012a), PTH (1-34) (Morgan et al, 2008), TGF-β1 (Ripamonti et al, 2001b) and thrombospondin 1 (TSP-1) (Gelse et al, 2011). Taken together these combinations have demonstrated increased defect regeneration from 1.4 to 5.3 fold in large animals (Ripamonti et al, 2010;Zhang et al, 2009b), and 1.2 to 15 fold in small animals Zhang et al, 2012a).…”
Section: Combination Administration Of Bmp-7mentioning
confidence: 99%
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“…Additionally, the use of parathyroidal hormone (PTH), growth hormone, steroids, calcitonin and vitamin D in systemic applications has also been shown to advance bone healing through stimulating osteogenesis, angiogenesis and osteoblast differentiation [27][28][29][30]. Various combinations of biomolecules have also been extensively evaluated in pre-clinical models with mostly positive results [27,[31][32][33][34][35][36][37].…”
Section: Biomoleculesmentioning
confidence: 99%
“…However, mechanical stability, a crucial requirement of bone healing, may not be achieved immediately. Combining bone stimulating growth factors with angiogenic factors [11,18], parathyroid hormone [15] and mesenchymal stem cells [8,11] is promising. The need to combine musculoskeletal growth factors with others, however, emphasizes the lack of independence of these mediators.…”
mentioning
confidence: 99%