Combined effects of noise and ototoxic drugs.

Falk, Stephen A.

doi:10.1289/ehp.72025

Cited by 36 publications

(9 citation statements)

References 59 publications

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“…Noise has also been implicated as causal of hearing loss, especially in patients concomitantly receiving ototoxic drugs such as aminoglycosides. 13,14 Additionally, noise has been implicated in contributing to critical care nurse burnout. 15 The purpose of the current study was to determine the causes of noise pollution in the hospital setting and to determine if behavior modification could have an impact on noise in the ICU.…”

Section: P Revious Investigations At Our Institution Havementioning

confidence: 99%

Identification and Modification of Environmental Noise in an ICU Setting

Kahn

Cook

Carlisle

et al. 1998

Chest

194

140

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Section: P Revious Investigations At Our Institution Havementioning

confidence: 99%

Identification and Modification of Environmental Noise in an ICU Setting

Kahn

Cook

Carlisle

et al. 1998

Chest

194

140

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“…Long et al [4] noticed changes in oxygenation and intracerebral pressure accompanying noise bursts and Gadeke et al [7] observed infant sleep disturbances: these observations are important, because sudden changes in intracerebral perfusion may lead to cerebral haemorrhage [8] and disturbances in sleep cycles due to noise may provoke abnormal hormone production [9]. Loud or prolonged sounds can produce hearing loss in the frequency range of the damaging sound [10]: speech for example, is a low-frequency sound and hearing damage in this range has an enormous impact on language development and communication [3].…”

Section: Introductionmentioning

confidence: 99%

Use of Sound-Absorbing Panel to Reduce Noisy Incubator Reverberating Effects

Bellieni

Buonocore²,

Pinto³

et al. 2003

Neonatology

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Objectives: To assess the amplification and distortion of noise in incubators by measuring noise levels from various sources under various conditions. Study Design: We recorded sound pressure levels (SPL) of background noise, baby crying, alarms and porthole closing with the incubator hood open or closed. Then we tried to reduce the sound level in the incubator by applying a sound absorbing panel to the ceiling of the hood. Results: The sound sources analysed produced very high SPL. In free field baby crying and porthole noise were, respectively, 81–83 dB and 70–71 dB, closing the hood they raised to 84–87 and 73–74 dB: this means that the noise perceived by a baby in the incubator had twice the SPL of the same noise emitted in a free field; alarm noise was 56–57 dB inside incubators. Sound emitted inside the hood was also distorted, i.e. it had different features from the same source in a free field. The insulating panel prevented amplification and distortion due to the hood and reduced the SPL of alarms. Only background noise did not decrease with the panel. Sound absorbing panel reduced baby’s crying, porthole noise and alarm noise SPL to 82–85, 70–71 and 50–51 dB, respectively. Conclusions: Incubators are reverberating environments, which amplify the baby’s cry and other noises produced inside the hood. The frequency components of noises are altered by the hood. The sound absorbing panel reduced this phenomenon.

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“…The frequency spectrum of the acoustic exposure determines the location of maximum damage to the organ of Corti, whereas its intensity and duration control the severity of damage (Davis et al, 1953;Stockwell et al, 1969;Falk, 1972). In our previous study, the damage from tonal stimulation similar to that of the present experiment (i.e., 95 dB SPL tone at 2 kHz) but used for a longer period was characterized by cell damage limited to the second turn, i.e., to the segments 7 to 11 mm from the apex , and it affected outer as well as inner hair cells.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of cochlear hair cell loss by acoustic stimulus and gentamicin in the guinea pig

Bhattacharyya

Dayal

1991

Anat. Rec.

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We explored the possibility of synergism between a pure-tone stimulus and gentamicin in causing cochlear injury by analyzing hair cell loss. Guinea pigs receiving daily injections of gentamicin (200 mg/kg body wt.) for 1 week were exposed to a 2 kHz tone (95 dB SPL, 2 hours daily). Surface preparations of the spiral organ were studied by phase contrast microscopy, and the extent of hair cell loss in the entire organ of Corti was recorded in cytocochleograms. Gentamicin by itself was slightly ototoxic, damaging the innermost row of outer hair cells, whereas exposure to sound alone caused no hair cell loss. Combined antibiotic and acoustic exposure produced extensive cochlear damage. A few animals showed massive hair cell degeneration and collapse of the organ of Corti, except in the apical turn. The site of damage was possibly determined by the frequency of the sound stimulus. Thus, an intermittent tonal stimulus such as that used in the present experiment can be harmless by itself, but causes injury to cochlear hair cells in guinea pigs when administered in combination with gentamicin.

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Combined effects of noise and ototoxic drugs.

Abstract: Images FIGURE 1. FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. FIGURE 14.

Cited by 36 publications

References 59 publications

Identification and Modification of Environmental Noise in an ICU Setting

Identification and Modification of Environmental Noise in an ICU Setting

Use of Sound-Absorbing Panel to Reduce Noisy Incubator Reverberating Effects

Potentiation of cochlear hair cell loss by acoustic stimulus and gentamicin in the guinea pig

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