Combined effects of mulch film-derived microplastics and atrazine on oxidative stress and gene expression in earthworm (Eisenia fetida)

Cheng, Yali; Zhu, Lusheng; Song, Wenhui; Jiang, Chunying; Li, Bing; Du, Zhongkun; Wang, Jinhua; Wang, Jun; Li, Dengtan; Zhang, Kaihua

doi:10.1016/j.scitotenv.2020.141280

Cited by 125 publications

(37 citation statements)

References 62 publications

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“…To the best of our knowledge, only very few papers report data on reproductive toxicity mediated by OS and which are related to joint exposure to MPs/NPs and other xenobiotics. The four-week exposure to MPs and pesticide atrazine in earthworm (Eisenia fetida) determined ROS accumulation and MDA production and a decrease in SOD, CAT, and GST activity [132]. Deng et al [24] showed that phthalates esters (PAEs) may strengthen MP-induced reproductive impairment in mice and hypothesized that the effect is related to OS.…”

Section: Reproductive Toxicity Of Micro/nanoplastics In Combination With Other Chemical Pollutants Mediated By Oxidative Stressmentioning

confidence: 99%

“…To date, the role of the combined exposure to MPs/NPs and other chemical pollutants on reproductive toxicity has been rarely investigated. Cheng et al [ 132 ] reported an increase of annetocin mRNA expression in earthworms ( Eisenia fetida ) exposed to MPs and atrazine with respect to each pollutant alone. Annetocin is considered a regulating gene involved in the reproduction process of soil earthworms.…”

Section: Effects Of Micro/nanoplastics On Reproductionmentioning

confidence: 99%

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The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress

et al. 2022

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Micro- and nanoplastics (MPs/NPs) are among the most widely distributed pollutants in the environment. It has been suggested that exposure to MPs/NPs can trigger toxicity pathways among which inflammation and oxidative stress (OS) play a pivotal role. Once absorbed, MPs/NPs may act locally or access the bloodstream and, following the translocation process, reach several organs and tissues, including the gonads. Notably, MPs/NPs can bioaccumulate in human and murine placenta, opening new scenarios for toxicological evaluations. We review recent studies on the effects of MPs/NPs on the reproductive health in aquatic and terrestrial organisms of both sexes, focusing on the role of OS and the antioxidant defence system failure as the main underlying mechanisms. Alterations in gametogenesis, embryonic and offspring development, and survival have been shown in most studies and often related to a broken redox balance. All these detrimental effects are inversely related to particle size, whereas they are closely linked to shape, plastic polymer type, superficial functionalization, concentration, and time of exposure. To date, the studies provide insights into the health impacts, but no conclusions can be drawn for reproduction toxicity. The main implication of the few studies on antioxidant substances reveals their potential role in mitigating MP-induced toxic effects.

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Section: Reproductive Toxicity Of Micro/nanoplastics In Combination With Other Chemical Pollutants Mediated By Oxidative Stressmentioning

confidence: 99%

Section: Effects Of Micro/nanoplastics On Reproductionmentioning

confidence: 99%

The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress

et al. 2022

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“…Similar to the studies on single exposure to microplastics, combined exposures of earthworms to microplastics and chemicals caused changes in the biomarkers related to stress. 38,39,[43][44][45][46] Combined exposure to chemicals and microplastics could also damage the nerve transmission process of earthworms 39) , as observed with the earthworms exposed to only microplastics. 33) Most studies did not report direct relationship between exposure to microplastics and death of earthworms, but some reported reducted weight and growth of earthworms 40,43,45) and increased mortality.…”

Section: Combined Exposure To Microplastics and Chemicalsmentioning

confidence: 88%

Current Research Trends on the Effects of Microplastics in Soil Environment Using Earthworms: Mini-Review

Hur¹,

Jho²

2021

J Korean Soc Environ Eng

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Objectives : The increase in the amount of plastics used has brought convenience to human life, but has also caused various environmental problems such as problems related to microplastics. Microplastics are defined as small plastic particles with a size of under 5 mm. As of now, research on microplastics has been largely focusing on the marine environment, and studies on microplastics in soil environment are on the rise in very recent years. Thus, the environmental impact of microplastics on the soil environment are insufficient than those on the marine environment, and there is a need for more studies. Therefore, this mini-review attempts to examine the studies on microplastics in soil environment focusing on the studies using earthworms as a test species.Methods : Published studies on microplastics in soil environment were identified by searching Web of Science. The focus of this mini-review was to gather the published articles reporting the effect of microplastics on earthworms in the absence and presence of other chemical contaminants.Results and Discussions : The number of studies evaluating the effect of microplastics in soil are significantly increasing, and earthworms are being mostly used as the test species. Experimental conditions were divided into two types: Single exposure to microplastics and combined exposure to microplastics and other chemicals. In most studies, changes in the biomarkers which are related to oxidation stress of earthworms were confirmed, and direct damage to intestinal tissues of earthworms was also observed. However, in the case of the changes of the biomarkers of earthworms, their patterns were different depending on the experimental conditions (i.e., concentrations of microplastics and chemicals, microplastics size and type, exposure period, etc.). Also, the avoidance behavior of earthworms and the internal accumulation of microplastics and co-existing chemicals were not consistent among the studies. Thus, the effects of microplastics on earthworms are not clear yet, although they seem to have some adverse effects.Conclusions : This study showed that the interest in the impact of microplastics in the soil environment has been increased recently, and earthworms are being used mostly in the studies. Yet, there is no standardized method to study the effect of microplastics on earthworms. Studies so far confirmed that microplastics induced changes in and outside of earthworm bodies. However, due to various experimental conditions, it seemed that consistent results could not be confirmed in those researches. For that reason, this study suggests that standardized research methods for microplastics researches using earthworms as a test species need to be established and need to be applied to further studies.

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“…Due to the extensive and long-term application of ATZ, the water environment is generally polluted, and the environmental concentration is expected to reach 2.667 mg/L [ 12 ]. Growing evidence has recently shown ATZ to have different adverse effects on the endpoint of DNA damage [ 13 ], oxidative stress [ 14 , 15 , 16 ], behavior [ 17 ], endocrine disruption [ 18 ] and immune toxicity [ 19 ] in zebrafish and other aquatic organisms. In animals, glutathione transferases (GSTs) and cytochrome P450, which are responsible for metabolism, are located in the liver and can metabolize ATZ to a variety of products, including desisopropyl atrazine (DIP), desethyl atrazine (DE), atrazine-glutathione (ATZ-SG), atrazine−mercapturate (ATZ−mercap) and diaminochlorotriazine (DACT) [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Atrazine Exposure Induces Hepatic Metabolism Disorder in Male Adult Zebrafish

Zhang

Wang

Qian

et al. 2022

Toxics

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Atrazine (ATZ) is a herbicide used in agricultural production and has been detected in surface water due to its widespread use worldwide. This may pose a threat to the health of aquatic animals. To explore the ATZ−induced hepatic metabolism disorder, male zebrafish were exposed to 300 and 1000 μg/L ATZ for 21 days, respectively. The results revealed that ATZ exposure significantly reduced hepatic triglyceride (TG) levels, while significantly (p < 0.05) increased pyruvate (PYR) and total cholesterol (TC) levels. In addition, the liver sample from the 1000 μg/L ATZ−treated group was used for GC/MS metabolomic analysis. The principal component analysis (PCA) model showed significant separation of the 1000 μg/L ATZ group from the control group, indicating that ATZ exposure altered hepatic metabolism in male adult zebrafish. A total of 29 significantly (p < 0.05) different metabolites were observed and identified in the ATZ−treated group. Moreover, the most disturbed pathways by ATZ were the arginine and proline metabolic pathways, followed by the glutathione metabolic pathway. Three and two metabolites were significantly altered in the arginine and proline metabolic pathways and glutathione metabolic pathway, respectively. Based on these results, we suggested that ATZ was capable of altering liver metabolism in zebrafish and that its ecological risk to aquatic organisms cannot be ignored.

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Combined effects of mulch film-derived microplastics and atrazine on oxidative stress and gene expression in earthworm (Eisenia fetida)

Cited by 125 publications

References 62 publications

The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress

The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress

Current Research Trends on the Effects of Microplastics in Soil Environment Using Earthworms: Mini-Review

Atrazine Exposure Induces Hepatic Metabolism Disorder in Male Adult Zebrafish

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