Combined effects of high‐frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome

Abstract

Our data indicate that HFV, especially in combination with surfactant therapy, may be superior to CV for treatment of respiratory failure in this animal model of meconium aspiration syndrome.

Erythropoietin may attenuate lung inflammation in a rat model of meconium aspiration syndrome

“…This process results in the significant increase of NF-κB-dependent pro-inflammation cytokines, and these cytokines eventually promote lung tissue barrier permeability and enhances inflammatory cell recruitment to the area of injury. [29] Moreover, Ji et al showed that rhEPO pretreatment inhibited NF-κB p65 and the release of proinflammatory cytokines. [14] Likewise, attenuation of cytokines was observed with rhEPO pretreatment in meconium-instilled rats in our study.…”

“…In experimental meconium aspiration, although inflammatory lung changes with ultrastructural signs of cellular injury had been seen earliest within 3 hours, [29] these changes have usually been observed within 6 hours, with a maximum of 12 to 48 hours after exposure. [5,21,30,31] This may be why rhEPO has no statistically significant effect on the lung tissue MPO activity in the meconium-exposed lung areas.…”

Dexamethasone Alleviates Meconium‐Induced Airway Hyperresponsiveness and Lung Inflammation in Rabbits

“…Recently, we combined exogenous surfactant administration and high-frequency ventilation. 6,7 Also seemingly of promise is the coadministration of exogenous surfactant and nonionic polymers, 8 inhaled nitric oxide, 9 or liquid ventilation. 10 However, these approaches do not directly influence the inflammation process generated in lungs after meconium aspiration.…”

Effects of Surfactant Lavage Combined With Intratracheal Budesonide Instillation on Meconium-Injured Piglet Lungs

“…Bolus surfactant supplementation with different ventilatory strategies has been studied as a means of alleviating this problem (11)(12)(13)(14). Among developing therapies, effective meconium debris removal without inactivating or washing out surfactant, namely, therapeutic bronchoalveolar lavage (BAL) with exogenous surfactant, is considered to be more effective because of the simultaneous removal of meconium debris in parallel with surfactant replacement (15)(16)(17)(18)(19).…”