Combined effects of hepatitis B virus infection and elevated alanine aminotransferase levels on dyslipidemia

Liu, Peng-Tzu; Hwang, An Chun; Chen, Jong-Dar

doi:10.1016/j.metabol.2012.07.022

Cited by 40 publications

(52 citation statements)

References 27 publications

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“…For “Elevated TG”, the pooled OR was from 14 studies [10–16, 26, 28, 30, 31, 33–35], and the SMD was from 14 studies [10, 16, 17, 26, 31, 34, 36, 37, 39, 42, 44–47]. They are not identical.…”

Section: Resultsmentioning

confidence: 99%

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Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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Background and aimAs there is conflicting evidence for the relationship between hepatitis B virus surface antigen (HBsAg) positivity and the prevalence of metabolic syndrome (MetS), we performed a meta-analysis to investigate whether HBsAg positivity affects the incidence of MetS.MethodsObservational studies on the relationship between HBsAg positivity and MetS were obtained from PubMed, Web of Science, and the Cochrane Library in April 2016. The pooled odds ratios (ORs) of MetS and its components (central obesity, increased fasting glucose, increased blood pressure, dyslipidemia) for subjects with or without HBsAg positivity were synthesized. The standardized mean difference of MetS components between HBsAg-positive participants and healthy controls was calculated. Heterogeneity was explored with subgroup analysis and sensitivity analysis. Publication bias was detected using Egger’s test and Begg’s test.ResultsThirty studies were eligible for meta-analysis. The MetS OR for HBsAg-positive participants was significantly decreased compared with the controls [OR = 0.80, 95% confidence interval (CI), 0.70–0.90]. The negative effect of HBsAg positivity on elevated triglycerides (OR = 0.62, 95% CI, 0.59–0.64) was strong, while that for increased fasting blood glucose was weak (OR = 0.94, 95% CI, 0.90–0.98). The pooled ORs of central obesity (OR = 0.97, 95% CI, 0.91–1.04), reduced high-density lipoprotein cholesterol (OR = 0.98, 95% CI, 0.83–1.14), and elevated blood pressure (OR = 1.00, 95% CI, 0.80–1.25) for HBsAg-positive participants were all not significantly different compared with the controls. No publication bias was detected.ConclusionsSerum HBsAg positivity is inversely associated with the prevalence of MetS. Among the five components of MetS, elevated triglycerides had the strongest inverse relationship with HBsAg positivity.

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Section: Resultsmentioning

confidence: 99%

“…For “Elevated BP”, the pooled OR was from 11 studies [10–15, 28, 30, 31, 33, 42]; the SMD of systolic BP was from 10 studies [10, 11, 17, 31, 33, 36, 37, 42, 44, 45], and the SMD of diastolic BP was from nine studies [10, 11, 17, 31, 33, 36, 37, 42, 45]. …”

Section: Resultsmentioning

confidence: 99%

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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“…The liver is a highly resilient organ that plays a vital role in nutrition and detoxification (Schmid, 1976), and surrogate markers for liver disease, such as elevated ALT (e-ALT) (Liu et al, 2012;Mohammad Ebrahim Ghamar-Chehreh, 2012;Ruhl & Everhart, 2009), are normalized within a relatively short period following liver repair (Bruckner et al, 1986;Duncan et al, 1998;Hoet et al, 2002;Jones et al, 1995;Venkateswara Rao, 2006;Watanapa, 1996). Therefore, the exposure to hazards in the workplace raises concerns when they are present as barriers to the normalization of e-ALT.…”

Section: Introductionmentioning

confidence: 99%

Long-term day-and-night rotating shift work poses a barrier to the normalization of alanine transaminase

Lin

Hsieh

Chen

2013

Chronobiology International

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To evaluate the impact of day-and-night rotating shift work (RSW) on liver health, we performed a retrospective analysis of the association between long-term RSW exposure and the normalization of plasma alanine transaminase (ALT) levels over a five-year period. The data from physical examinations, blood tests, abdominal sonographic examinations, personal histories, and occupational records were collected from a cohort of workers in a semiconductor manufacturing company. The sample population was divided into three subgroups for analysis, according to self-reported shift work status over the five-year interval: persistent daytime workers, workers exposed intermittently to RSW (i-RSW), and workers exposed persistently to RSW (p-RSW). Records were analyzed for 1196 male workers with an initial mean age of 32.5 years (SD 6.0 years), of whom 821 (68.7%) were identified as rotating shift workers, including 374 i-RSW (31.3%) and 447 p-RSW workers (37.4%). At the beginning of the follow-up, 275 were found to have elevated ALT (e-ALT): 25.1% daytime workers, 23.0% i-RSW workers, and 21.3% p-RSW workers (p = 0.098). Of those with e-ALT at the beginning, 101 workers showed normalized serum ALT levels at the end of five-year follow-up: 40 (10.7%) of 375 daytime workers, 32 (8.6%) of 374 i-RSW workers, and 29 (6.5%) of 447 p-RSW workers (p = 0.016). Compared with the workers having persistent e-ALT at the end of follow-up, the workers normalized serum ALT levels had significantly lesser exposures to RSW during follow-up. By performing multivariate logistic regression analyses, and comparing with the persistent daytime co-workers, after controlling for confounding variables (age, occupational factors, educational levels, lifestyle factors, metabolic syndrome, hepatovirus infection, and fatty liver), analysis indicated that the workers exposed to p-RSW were 46% less likely (OR, 0.54; 95% CI, 0.30-0.95; p = 0.03) to attain normal ALT levels within a five-year interval. These observations demonstrate that persistent day-and-night RSW pose a vigorous obstacle to the normalization of e-ALT among workers with preexisting abnormal liver function. We suggest that workers and managers approach with caution the consideration of assigning or accepting long-term day-and-night RSW when an employee health screening shows evidence of abnormal liver function.

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“…It has been demonstrated that HBV carriers have decreased levels of total cholesterol, high-density lipoprotein, and lowdensity lipoprotein, suggesting that HBV infection counteracts dyslipidemia [7][8][9][10] . Moreover, LS in chronic HBV patients is associated with changes in anthropometric indices and metabolic factors but not HBV itself 11 .…”

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confidence: 99%

Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers

Nau

Soares

Shiozawa

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Combined effects of hepatitis B virus infection and elevated alanine aminotransferase levels on dyslipidemia

Cited by 40 publications

References 27 publications

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Long-term day-and-night rotating shift work poses a barrier to the normalization of alanine transaminase

Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers

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