Combined Effects of Green Tea Extracts, Green Tea Polyphenols or Epigallocatechin Gallate with Acarbose on Inhibition against α-Amylase and α-Glucosidase in Vitro

Gao, Junjie; Xu, Ping; Wang, Yuefei; Wang, Yiqi; Hochstetter, Danielle

doi:10.3390/molecules180911614

Cited by 94 publications

(77 citation statements)

References 16 publications

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“…Therefore, plant based α-amylase and α-glucosidase inhibitors are likely to be useful in regulating blood-glucose level (Gao et al, 2013). Hypoglycemic effect of Artemisia herba alba may be due to α-amylase and α-glucosidase inhibitory potential.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Jemaa¹,

Sarra²,

Hmed³

et al. 2015

International J. of Pharmacology

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A B S T R A C TArtemisia herba alba was widely used in traditional medicine for the treatment of diabetes. The objective of this study was to evaluate the antidiabetic, antihyperlipidemic and antioxidant effects of Artemisia herba alba extract on high fat diet and diabetic models. Wistar albinos male rats were divided into four groups, the first was fed with high fat diet, the second was mimetic diabetes type II with high fat diet combined with double low dose of streptozotocin , the third was a model of type I diabetes with high dose of streptozotocin and the fourth was a control group. The ethanolic extract of Artemisia herba alba was given orally (2 g kgG 1 b.wt.) and daily for a period of 8 weeks. Our results showed that Artemisia herba alba treatment reduces the blood glucose level significantly in type II diabetic group (17.50±2.34 g LG 1 vs., 10.93±3.19 g LG 1 ). The plasma lipoproteins HDL, LDL-cholesterol and the triglyceride levels were altered by high fat diet and also by streptozotocin injection. These levels were also reverted back to near normalcy by treatment. Lipid peroxidation was decreased significantly by Artemisia herba alba supplementation in high fat diet and diabetic groups (p<0.05). Treatment with investigational drug increases antioxidant enzymes activities (superoxide dismutase and catalase in liver and kidneys) for type I and type II diabetic groups. In conclusion, this study suggests that the Artemisia herba alba has a beneficial effect in controlling diabetes by reducing lipid peroxidation and increasing antioxidant enzymes activities, which reduces the risk of developing diabetes complications.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Jemaa¹,

Sarra²,

Hmed³

et al. 2015

International J. of Pharmacology

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“…However, the use of these drugs may cause side effects such as abdominal discomfort, flatulence, meteorism and diarrhea [21][22][23][24] . The use of natural products as alternate approaches for existing medications for the treatment of diabetes mellitus is growing worldwide.…”

Section: Discussionmentioning

confidence: 99%

Anticaries and Alfa-Amylase Inhibitory Activity of Jasminum Arborescens Roxb. (Oleaceae) Leaves Extract

K.Bhagath¹,

T.R²,

N³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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The aim of the present study was to determine anti caries and α-amylase inhibitory activity of leaf extract of Jasminum arborescens Roxb. (Oleaceae). Anti caries activity was determined by Agar well diffusion assay against seven clinical isolates of Streptococcus mutans (Sm-01 to Sm-07) recovered from dental caries subjects. Enzyme inhibitory activity was tested against α-amylase by spectrophometric method using starch as substrate. The extract exhibited dose dependent inhibition against cariogenic isolates. Among seven isolates, isolate Sm-04 and Sm-06 were inhibited to higher and least extent respectively. The extract was found to cause inhibition of α-amylase activity in a dose dependent manner and its IC50 value was found to be 17.45 mg/ml. The inhibitory activity could be attributed to the presence of secondary metabolites. The plant may be a potential source for development of agents which are active against dental caries pathogens and for diabetes mellitus.

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“…The large quantity of Polyphenols plants exhibited high antioxidant and α-glucosidase activity. 4 Some antioxidant mechanism has been found to have a good relationship with the α glucosidase inhibitory activity of medicinal plants, especially for DPPH scavenging activity and inhibiting lipid peroxidation. A research has been proof that the high DPPH and hydroxyl radical scavenging activity of Murraya koenigii leaf extracts resulted the high of their α-glucosidase inhibitory properties.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antidiabetes Capacity of Hexane, Ethylacetate and Ethanol Extracts of Durio zibethinus Murr. Root

Evary¹,

Nur²

2018

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Introduction:Active natural products from medicinal plants are good sources for the antioxidant and antidiabetic agent. Natural antioxidants protect human health against oxidative stress and free radicals which cause degenerative disease such as diabetes. Objectives: This study was conduct to try one approach to treat diabetes that is to reduce gastrointestinal glucose absorption through the inhibition of the α-glucosidase enzyme. Methods: We make three different root extracts from Durio zibethinus Murr. The extracts were examined for their DPPH radical scavenging activity, antioxidant activity using β-carotene-linoleic acid assay, and their α-glucosidase inhibitory activity by a standard method. Additionally, we have also determined their total polyphenols and total flavonoids quantitatively using spectrophotometer UV-Vis. Results: The root extracts Durio zibethinus Murr. were effectively scavenged DPPH radicals in varied rate. The hexane (EHD), ethyl acetate (EEAD), and ethanol (EED) extracts revealed DPPH radical scavenging activity with IC 50 of 541.28, 83.95 and 11.24 µg/ml respectively and their β-carotene-linoleic acid assay showed activity with IC 50 of 273.58, 139.53, and 166.83 µg/ml, respectively. In vitro assay of the α-glucosidase inhibitory activity of the EHD, EEAD, and EED extracts showed an IC 50 of 119.84, 23.69, and 3.35 µg/ml, respectively. Conclution: In this present study, we found that ethanol extract revealed the most active antioxidant activity and the highest inhibitory activity against α-glucosidase enzyme. The total phenolics and total flavonoids contents of the extracts were studied, where the ethanol extracts were found to have the highest than that of other extracts. This study proofs the medicinal potencies of Durio zibethinus Murr. root extracts.

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Combined Effects of Green Tea Extracts, Green Tea Polyphenols or Epigallocatechin Gallate with Acarbose on Inhibition against α-Amylase and α-Glucosidase in Vitro

Cited by 94 publications

References 16 publications

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of Artemisia herba alba Extract on Experimental Diabetes

Anticaries and Alfa-Amylase Inhibitory Activity of Jasminum Arborescens Roxb. (Oleaceae) Leaves Extract

Antioxidant and Antidiabetes Capacity of Hexane, Ethylacetate and Ethanol Extracts of Durio zibethinus Murr. Root

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