Combined effects of dexmedetomidine and vatinoxan infusions on minimum alveolar concentration and cardiopulmonary function in sevoflurane-anesthetized dogs

Hector, Rachel C.; Rezende, Marlis L.; Mama, Khursheed R.; Steffey, Eugene; Raekallio, Marja; Vainio, Outi

doi:10.1016/j.vaa.2020.12.007

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Doppler has been shown to underestimate systolic blood pressure in anesthetized cats ( 34 ), therefore, SBP reported in this study may not represent its true systolic blood pressure. Based on study timeline, the equilibration time before the first noxious stimulation was longer than in other similar studies ( 21 , 23 ). Owing to fewer adjustments of isoflurane concentration in the placebo treatment, the duration of anesthesia and the time from gabapentin/placebo administration to the first and second MAC determination were less in the placebo treatment than in the gabapentin treatment.…”

Section: Discussionmentioning

confidence: 72%

“…Stimulation ceased if cats showed movements or no movements for a minute of tail clamping. Movements were defined as twisting, jerking of the head, running, or clawing movements of the limbs; while coughing, swallowing, or chewing were not considered positive responses ( 2 , 23 – 27 ). The determination of whether there was a positive reaction or not was always made by an investigator who was blinded to treatment.…”

Section: Methodsmentioning

confidence: 99%

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Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Chen

Yang²,

Li³

et al. 2023

Front. Vet. Sci.

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ObjectiveTo determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats.Study designProspective, randomized, blinded, crossover, and experimental study.AnimalsA total of six healthy adult cats (three male, three female) aged 18–42 months, weighing 3.31 ± 0.26 kg.MethodsCats were randomly given oral gabapentin (100 mg cat−1) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A paired t-test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set at p < 0.05. Data are mean ± standard deviation.ResultsIsoflurane MAC in the gabapentin treatment was 1.02 ± 0.11%, which was significantly lower than that in the placebo treatment (1.49 ± 0.12%; p < 0.001), decreasing by 31.58 ± 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments.Conclusion and clinical relevanceOral administration of gabapentin 2 h before starting MAC determination had a significant isoflurane MAC-sparing effect in cats with no observed hemodynamic benefit.

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Section: Discussionmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Chen

Yang²,

Li³

et al. 2023

Front. Vet. Sci.

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show abstract

“…However, in cats, dexmedetomidine worsened cardiac output (CO) compared with a higher, equipotent concentration of isoflurane administered alone (Pypendop et al 2011). The decrease in CO is the result of decreased heart rate (HR) and elevated systemic vascular resistance Hector et al 2021). These effects are mediated, at least in part, outside of the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine

Kobluk

Pypendop

2022

Veterinary Anaesthesia and Analgesia

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Nicardipine constant rate infusion alleviates the cardiovascular effects of dexmedetomidine infusions without affecting the minimal alveolar concentration in sevoflurane-anesthetized dogs

Akashi,

Murahata,

Tsuno

et al. 2024

Research in Veterinary Science

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Combined effects of dexmedetomidine and vatinoxan infusions on minimum alveolar concentration and cardiopulmonary function in sevoflurane-anesthetized dogs

Cited by 4 publications

References 27 publications

Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine

Nicardipine constant rate infusion alleviates the cardiovascular effects of dexmedetomidine infusions without affecting the minimal alveolar concentration in sevoflurane-anesthetized dogs

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