Combined Effects of Caffeine and Prostaglandin E₂ on the Proliferation of Osteoblast‐Like Cells (UMR106‐01)

Abstract

The present data for the first time demonstrate the possible implication of routine caffeine intake in the acceleration of pathological conditions of periodontitis. Thus, we propose that chronic caffeine intake is one of the possible risk factors in the advancement of pathology in the periodontitis patient. Further research in this area is warranted.

Effects of Coffee Intake and Intraperitoneal Caffeine on Bone Repair Process - A Histologic and Histometric Study

“…Possibly in CAF group there was greater plasma concentration of caffeine compared to the CO group, consequently higher bioavailability during the healing process after tooth extraction. This increased supply in the repair site possibly led to changes in intracellular mediators and thus to a lower viability and activity of osteoblasts to synthesize bone matrix, as evidenced in several studies (8,20,21), and also higher osteoclastic activity (19), which may have provided low maturity of bone trabeculae with the use of pure caffeine (Figs. 1F, I).…”

“…Studies have suggested that caffeine, a major constituent of coffee, is associated with a significantly increased risk of fractures, osteoporosis, periodontal disease and poor osseointegration of bone grafts (8,9,12). …”

“…While some studies have suggested that the effects of coffee/caffeine on bone metabolism are still controversial (6), others have reported that caffeine, a major constituent of coffee, is associated with a significant increase of periodontal diseases (7), fracture of osteoporotic bones (8), increase in urinary calcium and decrease of bone mineral density (6), as well as delay in bone repair process (9). Also, caffeine has an additional deleterious effect when administrated to animals with osteoporotic bones (10).…”

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells

“…However, a significant effect of caffeine on alkaline phosphatase activity was observed at 1 mM dose. Earlier studies on caffeine on osteoblast growth [19,23] have used caffeine doses in the range of 0.1-0.4 mM; while studies of caffeine on the release of intracellular calcium have used much higher concentrations of caffeine (4 and 10 mM) [24,25].…”

Coffee and Fitness. Coffee Suppresses Lipopolysaccharide-induced Liver Injury in Rats.

“…Accordingly, coffee must be a useful beverage for health. In contrast, some inves tigators have reported that caffeine and/or heavy coffee intake may serve as risk factors for lifestyle-related dis eases including heart disease and osteoporosis as well as periodontal diseases (3,4), which are intimately as sociated with nutrition, exercise, alcohol, smoking, and several other lifestyle factors. In the present study, we investigated a relationship between coffee and fitness; namely, the effects of coffee intake on body weight gain and serum cholesterol, cytokine and activities of GOT or GPT levels in lipopolysaccharide (LPS)-injected rats.…”