Combined Effects of Blood Serum as a Source of Endogenous β-Adrenoceptor-Sensitizing Agent and Its Analogues Histidine, Tryptophan, Tyrosine, Mildronat, and Preductal

Abstract

Human blood serum exhibiting β-adrenoceptor-sensitizing activity does not prevent manifestation of similar activity of histidine, tryptophan, tyrosine, mildronat, and preductal. This opens prospects for the use of analogues of endogenous β-adrenoceptor-sensitizing agent in clinical practice.

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

“…Tryptophan also affects hemodynamic parameters. With tyrosine and histidine, tryptophan belongs to a group of sensitizers of β-adrenergic receptors (ESBAR) [110]. Additionally, tryptophan increases the contractility of human myocardial cells, demonstrating an inotropic property [111].…”

Endogenous sensitizer of Beta-Adrenergic receptors (Esbar) and its analogs (Review)

“…Furthermore, ESBAR-activity showed nitroglycerin (10-5 g/mL) and ethanol in high concentrations (9,6 х 10-3 g/mL) [68,69]. Data on the ability of the histidine, tryptophan, tyrosine, mildronat and preductal improve ef iciency activate of beta 2 -AR were obtained in experiments with the LS NPRUH, including background spontaneous CA and under tone caused by high potassium (60 mM KCl) Krebs solution ( Figure 3) and against the background of an arti icial reduction of the ef iciency of the activation of beta 2 -AR by ozonated (5х10-8 g/mL) Krebs solution [51][52][53], lysophosphatidylcholine [71] or non-selective beta-blocker propranolol [56,58,59]. When this has been shown Horizontal lines under the mechanogram refl ect the time of exposure to substances, including trimetazidine, 10-7 g / ml (TPM-7) and adrenaline, 10-7 g/ mL (АДР-7).…”

“…However, regardless of the mechanism of histidine antidesenstization effect, we can talk about the possibility of using ESBAR and its analogs (tryptophan, tyrosine, mildronat, preductal) in clinical practice in order to improve the ef iciency of activation of beta 2 -AR of cells [58]. In this aspect is important data on the interaction of blood serum (as a source of ESBAR) with analog of ESBAR [59]. They were obtained in experiments with LS NPRUH, which evaluated the effect of a unique ESBAR (histidine, tryptophan, tyrosine, mildronat and preductal) on the inhibitory effect of adrenaline (10-8 g /mL), including the presence in the environment 100-fold dilution of serum of nonpregnant women study was conducted on the background tone, caused by high potassium (60 mM KCl) Krebs solution.…”

“…During these years, efforts have been made to clarify the physiological role of ESBAR, in particular, the ability of ESBAR to improve the ef iciency of activation of beta 2 -AR of smooth muscle from pig coronary artery [20,21], the arteries and veins of human umbilical cord [22][23][24], cow renal artery [25][26][27][28], cow trachea [21,[29][30][31], rat stomach [32,33], and also myocardium of frog [34][35][36][37], rats [36][37][38][39][40][41][42] and humans [43][44][45] and human erythrocytes [46]. In addition, our efforts were made to ind analogs of ESBAR [21,27-29, 35-37,39-43,45-60], to study the mechanism of action of ESBAR and its analogs [36,[38][39][40][41][42][43][56][57][58][59][60][61], on the role of ESBAR in the pathogenesis of somatic diseases -coronary heart disease [62]…”