2020
DOI: 10.1016/j.ejphar.2020.173031
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Combined effects of berberine and evodiamine on colorectal cancer cells and cardiomyocytes in vitro

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Cited by 34 publications
(15 citation statements)
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“…Studies have demonstrated that berberine possessed various pharmacological actions including anti-hypertensive, anti-arrhythmic, anti-bacterial and anti-cancer effects (Imenshahidi and Hosseinzadeh, 2016;Wang et al, 2017). Furthermore, studies found that berberine attenuated the radioresistance of colon cancer cells via repressing P-gp expression (Guan et al, 2020). Gao et al, found that berberine could sensitize breast cancer cells to different chemotherapeutic drugs (Gao et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Studies have demonstrated that berberine possessed various pharmacological actions including anti-hypertensive, anti-arrhythmic, anti-bacterial and anti-cancer effects (Imenshahidi and Hosseinzadeh, 2016;Wang et al, 2017). Furthermore, studies found that berberine attenuated the radioresistance of colon cancer cells via repressing P-gp expression (Guan et al, 2020). Gao et al, found that berberine could sensitize breast cancer cells to different chemotherapeutic drugs (Gao et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, in other types of cancer cells that are P-gp-positive, namely breast cancer or ovarian cancer cells, this combination also shows synergistic inhibitory effect. Berberine did not enhance the cytotoxicity of evodiamine in normal cells (Guan et al, 2020). In a different study, although evodiamine displayed antiproliferative and antimigratory activities in human gastric cancer (AGS) cells, it promoted metastasis by the concomitant increase in IL-8 secretion and mRNA expression of vascular cell adhesion protein.…”
Section: Combinations With Other Botanical Drugsmentioning
confidence: 92%
“…Current treatment for this disease, regardless of its capability of slightly improving the health status of patients, was found to easily trigger nonspecific cell death [20]. The cytotoxic effects of EVO against many cancers including colorectal cancer and non-small cell lung cancer have been reported, which were associated with the regulation of signaling pathway [21][22][23]. In initial experiments, the effects of different concentrations of EVO were investigated in the in vitro model and cell proliferation was found to be suppressed in a dosedependent manner.…”
Section: Discussionmentioning
confidence: 99%