Combined effects of arsenic and 2,2-dichloroacetamide on different cell populations of zebrafish liver

Ling, Chen; Su, Bei; Yu, Jing; Wang, Jinfeng; Hu, Haidong; Ren, Hongqiang; Wu, Bing

doi:10.1016/j.scitotenv.2022.152961

Cited by 7 publications

(1 citation statement)

References 45 publications

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“…The Liver of zebrafish is an especially valuable model for drug-induced injuries [72]. We found a subset of six experiments with IIS cells of the liver: GSE130487 [49], GSE150751 [73], GSE181987 [74], GSE192740 [75], GSE217839 [76], GSE228806 [66]. All of these experiments contain clusters of macrophages; other clusters of IIS cells include B cells (4/6), neutrophils (2/6), NK-like cells (2/6), dendritic cells (2/6), HSPCs (1/6), and T cells (4/6).…”

Section: Cranial Neural Crest (1) E-curd-123mentioning

confidence: 99%

Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei

Bobrovskikh,

Zubairova,

Doroshkov

2023

Biology

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The innate immune system is the first line of defense in multicellular organisms. Danio rerio is widely considered a promising model for IIS-related research, with the most amount of scRNAseq data available among Teleostei. We summarized the scRNAseq and spatial transcriptomics experiments related to the IIS for zebrafish and other Teleostei from the GEO NCBI and the Single-Cell Expression Atlas. We found a considerable number of scRNAseq experiments at different stages of zebrafish development in organs such as the kidney, liver, stomach, heart, and brain. These datasets could be further used to conduct large-scale meta-analyses and to compare the IIS of zebrafish with the mammalian one. However, only a small number of scRNAseq datasets are available for other fish (turbot, salmon, cavefish, and dark sleeper). Since fish biology is very diverse, it would be a major mistake to use zebrafish alone in fish immunology studies. In particular, there is a special need for new scRNAseq experiments involving nonmodel Teleostei, e.g., long-lived species, cancer-resistant fish, and various fish ecotypes.

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