Combined Effectiveness of β-Cyclodextrin Nanoparticles in Photodynamic Antimicrobial Chemotherapy on In Vitro Oral Biofilms

Vasconcelos, Maria Elisa Oliveira Costa; Cardoso, Andréia Alves; Silva, Josianne Neres da; Alexandrino, Francisca Jamila Ricarte; Stipp, Rafael Nóbrega; Nobre‐dos‐Santos, Marinês; Rodrigues, Lidiany Karla Azevedo; Steiner‐Oliveira, Carolina

doi:10.1089/photob.2019.4669

Cited by 9 publications

(1 citation statement)

References 38 publications

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“…Microorganisms present in the biofilm exhibit a multi-matrix structure, and high resistance to antibacterial agents and the host immune system [7]. In addition, thick biofilms can limit the penetration of photosensitizers and restrict the light transmission [8]. Therefore, bacteria present in the biofilm possess relatively lower sensitivity to PDT compared to bacteria in the planktonic state.…”

Section: Introductionmentioning

confidence: 99%

Effect of Potassium Iodide on Erythrosine-Mediated Photodynamic Therapy on Streptococcus Mutans Biofilms

Kim¹,

Park²,

Lee³

et al. 2022

J Korean Acad Pediatr Dent

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The aim of this in-vitro study is to evaluate the effect of potassium iodide (KI) on erythrosine-mediated photodynamic therapy (PDT) against Streptococcus mutans biofilms. S. mutans ATCC 25175 was cultured to form a biofilm on a hydroxyapatite disk. After diluting erythrosine to 20 μM and KI to 10, 50, and 100 mM, respectively, PDT was performed. The number of surviving bacteria was calculated as colony forming units (CFU)/mL and the statistical significance of the difference between groups was confirmed by Bonferroni post-hoc analysis. Cell viability was visually evaluated using confocal laser scanning microscopy (CLSM). As a result of the experiment, a significant decrease (p < 0.05) in CFU was observed in the experimental groups in which PDT was performed after applying KI regardless of the concentration of KI. In addition, a significant reduction (p < 0.05) in CFU was observed in the experimental group to which 100 mM KI was applied compared to 10 mM KI. The same results were confirmed when observing CLSM. KI significantly improved the efficacy of erythrosine-mediated PDT on S. mutans biofilms at all concentrations. This may compensate for the low sensitivity of PDT to biofilm-state bacteria strains, but it is necessary to establish an optimal clinical protocol through further research.

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Section: Introductionmentioning

confidence: 99%

Effect of Potassium Iodide on Erythrosine-Mediated Photodynamic Therapy on Streptococcus Mutans Biofilms

Kim¹,

Park²,

Lee³

et al. 2022

J Korean Acad Pediatr Dent

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Advances in Antimicrobial Organic and Inorganic Nanocompounds in Biomedicine

Wang

Makvandi

Zare

et al. 2020

Advanced Therapeutics

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Bacterial resistance to antibiotics is an important issue in contemporary society. To date, infection‐related problems persist despite intensive research efforts by chemists and biologists. Much effort has been devoted over the last decade to the development of organic/nonmetallic inorganic nanocompounds with antimicrobial activities for overcoming human infections and illnesses produced by antibiotic‐resistant pathogens. Both organic nanomaterials such as chitosan nanoparticles and conductive‐based polymer nanocompounds, as well as nonmetallic inorganic nanomaterials such as carbon‐based nanocompounds and modified nanoceramics, have been manufactured and employed in medicine for treating multidrug‐resistant infections. This review describes the most recent advances in the biomedical applications of antibacterial organic/nonmetallic inorganic nanocompounds.

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Inhibition of S. mutans after nanoparticle mediated photodynamic antimicrobial chemotherapy on oral biofilm flow-cell system using laser or LED

et al. 2021

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Combined Effectiveness of β-Cyclodextrin Nanoparticles in Photodynamic Antimicrobial Chemotherapy on In Vitro Oral Biofilms

Cited by 9 publications

References 38 publications

Effect of Potassium Iodide on Erythrosine-Mediated Photodynamic Therapy on Streptococcus Mutans Biofilms

Effect of Potassium Iodide on Erythrosine-Mediated Photodynamic Therapy on Streptococcus Mutans Biofilms

Advances in Antimicrobial Organic and Inorganic Nanocompounds in Biomedicine

Inhibition of S. mutans after nanoparticle mediated photodynamic antimicrobial chemotherapy on oral biofilm flow-cell system using laser or LED

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