Combined effect of vanadium and nickel on lipid peroxidation and selected parameters of antioxidant system in liver and kidney of male rat

Mahmoud, Kamal; Shalahmetova, T.; Deraz, Shaban; Umbayev, Bauyrzhan

doi:10.5897/ajb11.2949

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…In our environment, heavy metals are prevalent in air, soil and water. Virtually, they exist everywhere [1]. Among the heavy metals, copper (Cu) is an essential trace mineral which becomes harmful when the safe dose is surpassed [2].…”

Section: Introductionmentioning

confidence: 99%

Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats

et al. 2020

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Environmental and occupational exposures to copper (Cu) play a pivotal role in the etiology of some neurological diseases and reduced cognitive functions. However, the precise mechanisms of its effects on cognitive function have not been yet thoroughly established. In our study, we aimed to investigate the behavior and neurochemical alterations in hippocampus of male and female rats, chronically exposed to copper chloride (CuCl 2 ) and the possible involvement of oxidative stress. Twenty-four rats, for each gender, were divided into control and three test groups (n = 6), and were injected intraperitoneally with saline (0.9% NaCl) or CuCl 2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After the treatment period, Y-maze test was used for the evaluation of spatial working memory and the Morris Water Maze (MWM) to test the spatial learning and memory. Biochemical determination of oxidative stress levels in hippocampus was performed. The main results of the present work are working memory impairment in spatial Y-maze which induced by higher Cu intake (1 mg/kg) in male and female rats. Also, In the MWM test, the spatial learning and memory were significantly impaired in rats treated with Cu at dose of 1 mg/kg. Additionally, markers of oxidative stress such as catalase, superoxide dismutase, lipid peroxidation products and nitric oxide levels were significantly altered following Cu treatments. These data propose that compromised behavior following Cu exposure is associated with increase in oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats

et al. 2020

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“…The toxicity of these metals is primarily related to the body's responses to oxidative stress without the enzymatic systems within the body, which causes the neurotoxicity, hepatotoxicity, and nephrotoxicity in humans and animals [8,9]. Lead (Pb) exclusion has a dose-response relationship with the changes in antioxidant enzyme activities including Superoxide Dismutase (SOD) and Glutathione-S-Transferase (GST) [10].…”

Section: Introductionmentioning

confidence: 99%

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

Hosseini

Amani

Moshrefi

et al. 2020

IJT

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Background: Zinc Oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were divided into eight experimental, control and sham groups. They received ZnO nanoparticles at 4, 8, 25, 50, 100, or 200 mg/kg, or normal saline intraperitoneally for 30 days twice a week. Then, the blood samples of the rats were collected by heart puncture for biochemical analyses, and then sacrificed. Finally, the liver and pancreas tissues were harvested for histopathological examinations. Results: Significant amounts of nanoparticles were accumulated in the liver and pancreas of the rats, causing tissue and cellular damages. The ZnO nanoparticles reduced the levels of serum triglyceride, glucose, cholesterol, albumin, and increased the bilirubin and liver enzymes, such as ALT, AST, ALP, amylase and lipase at high doses. In addition, the evidence of histopathological lesions, hyperemia, inflammatory cell infiltration, and necrosis were noted in the liver and pancreas tissue slides upon microscopic examinations. Finally, the body and liver weights decreased in the rat groups receiving ZnO nanoparticle dose dependently. Conclusion: ZnO nanoparticles had toxic effects on the liver and pancreas, leading to destructive tissue and cellular changes in the rats.

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The effect of vanadium on rat hypercholesterolemia in the presence and absence of statins

Nasr¹,

Saber²,

Hussam³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Vanadium may or may not be a cholesterol-lowering agent. It could potentially be used as an additional therapy or alone in therapies for treatment of dyslipidemia. This study aimed to investigate the effect of vanadium on hypercholesterolemia in the presence and absence of statins. Sixty rats were divided into five groups. The first group was kept on a normal diet and the second group was kept on a high fat diet. The three remaining groups of rats were prepared for the treatment; one group received simvastatin, one was given vanadium, and the third group was tested with both. Blood samples from all groups were investigated. Body functions were considered a tool in expressing efficacy and toxicity for the three types of treatment and were compared with the control groups. Vanadium alone causes marked increases in cholesterol levels. When added to statins, all lipid values were negatively affected as compared to the statins-only treated group. Rats with high fat diets showed significant (P≤ 0.05) elevation in the levels of serum triglycerides (TG), total cholesterol (TC), low density lipoprotein concentration (LDL-C) and very low density lipoprotein concentration (VLDL-C) as compared to the control group. All generated data proved that vanadium is impracticable for treating dyslipidemia. Vanadium is not safe or efficient in therapies for lowering cholesterol and other lipid levels.

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Combined effect of vanadium and nickel on lipid peroxidation and selected parameters of antioxidant system in liver and kidney of male rat

Cited by 4 publications

References 45 publications

Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats

Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

The effect of vanadium on rat hypercholesterolemia in the presence and absence of statins

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