Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study

Abstract

BackgroundPrevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees.MethodsA total of 394 male subjects aged 29–76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m2) was conducted.ResultsFor Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR.ConclusionThe present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.

Is Alcohol Drinking Associated with Renal Impairment in the General Population of South Korea?

“…Some studies in the general population have reported that alcohol consumption is inversely associated with the renal dysfunction or the incidence of chronic renal disease [10,11,12,13,14], whereas others have reported that alcohol consumption is positively related to renal impairment [15,16], or that there is no relationship between alcohol consumption and renal function [14,17,18]. Furthermore, there were no studies on alcohol consumption and renal function in Korean population, and the results of previous studies in other populations may be difficult to generalise to Korean populations due to ethnic differences[10,15,16,17,18,19,20] or dissimilar population subgroups [11,12,18]. The lack of evidence about the influence of alcohol drinking on renal function has limited the use of controls on alcohol drinking as a method for preventing and monitoring the progression of renal insufficiency.…”

Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery

“…Further, mtDNA haplogroups J and V have been associated with reduced susceptibility to chronic renal allograft dysfunction in comparison to haplogroup H 31 which has also been associated with a higher risk of the development of post-renal transplant diabetes 32 . Finally, a gene-environment interaction study suggested an association between the longevity-associated mt5178A genotype, regular alcohol consumption and better renal function in non-diabetic Japanese men 33 .…”

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies effect of aging on renal function in male Japanese health checkup examinees: an exploratory cross-sectional study

“…Green tea consumption was classified based on the number of cups of green tea per day (≤ 1 cup per day, 2–3 cups per day, 4–5 cups per day, and ≥ 6 cups per day). Selection of these lifestyle habits was based on previous research [15, 16, 21].…”

“…Multiple logistic regression analysis was conducted to calculate odds ratios (ORs) for the risk of reduced eGFR. Reduced eGFR was defined as < 90 mL/min/1.73 m 2 [15, 16, 24–26] or < 75 mL/min/1.73 m 2 [27]. For simple and multiple linear regression analyses, age (< 50 years = 1, 50–59 years = 2, ≥ 60 years = 3), habitual smoking (never- or ex-smokers = 0, 1–20 cigarettes smoked per day = 1, ≥ 21 cigarettes smoked per day = 2), alcohol consumption (non- or ex-drinkers = 0, occasional drinkers = 1, daily drinkers = 2), green tea consumption (≤ 1 cup per day = 1, 2–3 cups per day = 2, 4–5 cups per day = 3, ≥ 6 cups per day = 4), and antihypertensive treatment (not receiving antihypertensive treatment = 0, receiving antihypertensive treatment = 1) were numerically coded.…”

“…Several clinical epidemiological studies reported that Japanese individuals with Mt5178A genotype are more resistant to adult-onset diseases than those with Mt5178C genotype [10–14]. Moreover, our previous research reported that Mt5178 C/A polymorphism modulates the effect of alcohol consumption [15] or green tea consumption [16] on renal function, evaluated by estimated GFR (eGFR). Although an association between Mt5178 C/A polymorphism and physiological aging effect on pulmonary function was reported [17], an association between Mt5178 C/A polymorphism and effect of physiological aging on kidney function has not yet been reported.…”