Combined effect of microplastic, salinomycin and heating on Unio tumidus

Мартынюк, В.; Khoma, Vira; Matskiv, Tetyana; Yunko, Kateryna; Gnatyshyna, Lesya; Stoliar, Оksana; Faggio, Caterina

doi:10.1016/j.etap.2023.104068

Cited by 43 publications

(8 citation statements)

References 91 publications

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“…Importantly, we almost did not observe signs of oxidative stress in the same exposures (Martyniuk et al 2023) and in this study due to the low total antioxidant capacity. Similarly, the chronic exposure of two marine bivalves, Mercenaria mercenaria and Crassostrea virginica, to temperatures elevated by 5°C separately or under hypercapnia also minimally affected the cellular oxidative stress responses indicated by protein carbonyls, MDA-protein conjugates, and total antioxidant capacity, despite the physiological disturbances (Matoo et al 2013).…”

supporting

confidence: 45%

“…Both low-weight cellular thiols, GSH and metallothioneins, and both nicotinamide coenzyme forms were depleted in this exposure only, which impaired their functions. Under the heating, the activation of the biotransformation enzymes and catalase, unlike in the Mix-group, was also abolished (Martyniuk et al 2023). The differences between the responses of molluscs to mixtures under two temperatures were re ected by the discriminant analysis (Fig.…”

Section: Particular Responses To Microplastics and Salinomycin And Th...mentioning

confidence: 99%

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Reductive stress and apoptotic activities in bivalve mollusc Unio tumidus exposed to the combination of microplastics, antibiotic salinomycin and heating

Мартынюк

Matskiv

Yunko

et al. 2023

Preprint

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Multistress effects lead to unpredicted consequences in aquatic ecotoxicology and are extremely concerning. The goal of this study was to trace how specific effects of the antibiotic salynomycin (Sal) and microplastics (MP) on the bivalve molluscs are manifested in the combined environmentally relevant exposures. Unio tumidus specimens were treated with Sal (0.6 µg L− 1), MPs (1 mg L− 1, 2 µm size), and both at 18°C (Mix) and 25°C (MixT) for 14 days. The redox stress and apoptotic enzyme responses and the balance of Zn/Cu in the digestive gland were analyzed. The shared signs of stress included a decrease in NAD+/NADH and Zn/Cu ratios and lysosomal integrity, and an increase in Zn-metallothioneins and cholinesterase levels. MP caused a decrease in the glutathione (GSH) concentration and redox state, total antioxidant capacity, and Zn levels. MP and Mix induced coordinated apoptotic/autophagy activities, increasing caspase-3 and cathepsin D (CtD) total and extralysosomal levels. Sal activated caspase-3 only and increased by five times Cu level in tissue. Due to the discriminant analysis, the cumulative effect was evident in the combined exposure at 18°C. However, under heating, the levels of NAD+, NADH, GSH, GSH/GSSG and metallothionein-related thiols were decreased, and coordination of the cytosolic and lysosomal death stimuli was distorted, confirming that heating and pollution could exert unexpected synergistic effects on aquatic life.

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supporting

confidence: 45%

Section: Particular Responses To Microplastics and Salinomycin And Th...mentioning

confidence: 99%

Reductive stress and apoptotic activities in bivalve mollusc Unio tumidus exposed to the combination of microplastics, antibiotic salinomycin and heating

Мартынюк

Matskiv

Yunko

et al. 2023

Preprint

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“…Exposure to MPs and nanoparticles is reported to be associated with the production of reactive oxygen species (ROS) [45][46][47]. ROS are regularly produced as part of metabolism but are counterbalanced by an effective antioxidant system present in the organism [13,48,49]. If the level of ROS increases in the body, it can lead to conditions such as oxidative stress, inflammation, and cellular damage.…”

Section: Discussionmentioning

confidence: 99%

Individual and Combined Toxic Effects of Nano-ZnO and Polyethylene Microplastics on Mosquito Fish (Gambusia holbrooki)

Banaee¹,

Zeidi²,

Sinha

et al. 2023

Water

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The omnipresence of microplastics and nanoparticles has led to their entry into the fresh and marine aquatic systems and affected the biota. The present study aims to evaluate the impact of the interaction of polyethylene microplastic (PE-MPs) and zinc oxide nanoparticles (ZnO-NPs) in mosquito fish, Gambusia holbrooki. For this, fish were exposed to 100 µg L−1 PE-MPs (group 2), 200 µg L−1 PE-MPs (group 3), 50 µg L−1 ZnO-NPs (group 4), 50 µg L−1 ZnO-NPs combined with 100 µg L−1 PE-MPs (group 5), and 200 µg L−1 PE-MPs (group 6) and control (group 1) for 14 days. The assessment was made through accumulation studies (MPs and Zn) and antioxidant assay. Significant elevation in the activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase levels was observed in ZnO-NPs alone and in combination with PE-MPs (100 and 200 µg L−1) groups only. High malondialdehyde levels were observed in all the exposed groups. Concordantly total antioxidant (TAN) levels displayed a significant reduction in all treated groups compared to control. Accumulation study on microplastic suggested liver-targeted accumulation of PE-MPs, while for ZnO-NPs, observed PE-MPs assisted accumulation. The study affirms the induction of oxidative stress and ZnO-NPs-induced toxicity facilitated by PE-MPs in fish.

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“…Marine and freshwater organisms can ingest and accumulate microplastics (Abbasi et al, 2018). A big challenge is the possibility of transferring these compounds to the edible part of fish and mollusks, which has caused concern about the quality and safety of these food compounds (Asmonaite et al, 2018; Martyniuk et al, 2023). Neurotoxicity is the main toxic effect of PS‐MPs reported in various aquatic organisms (Xiong et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)

Ahmadifar,

Shohreh,

Kalhor

et al. 2024

J World Aquaculture Soc

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This trial was performed in order to investigate the response of zebrafish (Danio rerio) to dietary exposure to polystyrene nanoplastics (PS‐NPs) under laboratory conditions on fish growth and health. Healthy zebrafish (n=240) were divided into 12 tanks and fed with diets including 0 (T0), 100 (T1), 500 (T2), and 1000 (T3) mg kg−1 synthesized polystyrenes nanoplastics (PS‐NPs) for 30 days. At the end of trial, fish fed the PS‐NPs supplementation showed weight gain percentages of 79.45%, 70.35%, and 61.88% for T1, T2, and T3 groups, respectively, compared with 87.39% in the control fish. The SOD, GPX and MDA activities and cortisol levels increased by 47%, 32% and 35% and 46%, respectively, especially at high‐dose administration (p < 0.05). The expression of GPX (T2‐81% and T3‐82%) and SOD (T2‐101% and T3‐187%) were remarkably upregulated in T2 and T3 groups. Moreover, the relative gene expression of HSP70, interleukin‐1 (IL1), Interferon γ (IFN‐γ) and tumor necrosis factor‐α (TNF‐α) increased by 178%, 202%, 154% and 307%, respectively, especially at high‐dose administration (p < 0.05). The results of the present study demonstrated that exposure to PS‐NPs especially at high concentrations (500 and 1000 mg kg−1 of diet) negatively influenced growth, health status‐, antioxidant‐, and immunity‐related gene expression responses of zebrafish.

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Combined effect of microplastic, salinomycin and heating on Unio tumidus

Cited by 43 publications

References 91 publications

Reductive stress and apoptotic activities in bivalve mollusc Unio tumidus exposed to the combination of microplastics, antibiotic salinomycin and heating

Reductive stress and apoptotic activities in bivalve mollusc Unio tumidus exposed to the combination of microplastics, antibiotic salinomycin and heating

Individual and Combined Toxic Effects of Nano-ZnO and Polyethylene Microplastics on Mosquito Fish (Gambusia holbrooki)

Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)

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