Combined Effect of Maternal Separation and Early-Life Immune Activation on Brain and Behaviour of Rat Offspring
Bharti Biswas,
Valsamma Eapen,
Margaret J. Morris
et al.
Abstract:Adversity during early life, a critical period for brain development, increases vulnerability and can have a lasting impact on the brain and behaviour of a child. However, the long-term effects of cumulative early-life stressors on brain and behaviour are not well known. We studied a 2-hit rat model of early-life adversity using maternal separation (MS) and immune activation (lipopolysaccharide (LPS)). Rat pups underwent MS for 15 (control) or 180 (MS) minutes per day from postnatal day (P)2–14 and were admini… Show more
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