Combined effect of fluid and pressure on middle ear function

Dai, Chenkai; Wood, Mark W.; Gan, Rong Z.

doi:10.1016/j.heares.2007.11.005

Cited by 23 publications

(20 citation statements)

References 14 publications

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“…The significant reduction of middle ear compliance observed in this study differed from the recent findings in temporal bones by Dai et al (2008). In their human temporal bone study, the injection of 0.3 ml fluid plus air pressure in the middle ear did not cause a significant change of the middle ear compliance because the 0.3 ml fluid injected in the middle ear cavity is a small fraction of the air volume in human temporal bone.…”

Section: Guinea Pig Ome Modelcontrasting

confidence: 99%

“…The combination of effusion and negative pressure reduced the TM vibration at both low and high frequencies. The effect of middle ear effusion or pressure has been investigated in various studies in human temporal bones and animal models (Dirckx and Decraemer, 1992;von Unge et al, 1995;Murakami et al, 1997;Lee and Rosowski, 2001;Rosowski and Lee, 2002;Ravicz et al, 2004;Gan et al, 2006;Dai et al, 2007aDai et al, , 2008. At low frequencies (f < 400 Hz), the stiffness of the middle ear ossicular chain dominates the regulation of the TM movement while the mass affects TM vibration at high frequencies.…”

Section: Possible Mechanisms Of Middle Ear Movement Reduction In Omementioning

confidence: 99%

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Change of middle ear transfer function in otitis media with effusion model of guinea pigs

Dai

Gan

2008

Hearing Research

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Otitis media with effusion (OME) is an inflammatory disease of the middle ear that causes most cases of conductive hearing loss observed in the pediatric population. With the long term goal of evaluating middle ear function with OME, the aim of the current study was to create an animal model of OME in which middle ear transfer functions could be measured. In guinea pigs, OME was created by injecting lipopolysaccharide (LPS) into the middle ear. Evidence of OME was assessed by otoscopy, tympanometry, histology, and by measuring the volume of fluid in the middle ear. Vibrations of the umbo and round window membrane were measured with a laser Doppler vibrometer at frequency range of 200-40 kHz in three groups of 3, 7, and 14 days after injection of LPS. Changes in displacement of the umbo and round window membrane in response to 80 dB SPL sound in the ear canal were measured across the frequency range. Displacement of both the umbo and round window membrane was reduced at all time points following LPS injections. Further, the change of the displacement transmission ratio (DTR) from the tympanic membrane to the round window occurred mainly in chronic (e.g. 14 days post-LPS injection) OME ears. This study provides useful data for analyzing the change of middle ear transfer function in OME ears.

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Section: Guinea Pig Ome Modelcontrasting

confidence: 99%

Section: Possible Mechanisms Of Middle Ear Movement Reduction In Omementioning

confidence: 99%

Change of middle ear transfer function in otitis media with effusion model of guinea pigs

Dai

Gan

2008

Hearing Research

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“…In the literature, the middle ear transfer function is generally measured at the umbo, and has been studied using a single beam LDV (Gan et al 2004a;2006a, b;Dai et al 2007Dai et al , 2008. Gan et al (2006a, b) studied the umbo vibration in the normal ear and the ear with various liquid levels from 0.1 to 0.6 ml.…”

Section: Comparison With Published Measurementsmentioning

confidence: 99%

“…Sound-induced TM vibration has been measured at the umbo using laser Doppler vibrometry (LDV) (Goode 1994;Whittemore et al 2004;Gan et al 2004a;2006b;Dai et al 2007Dai et al , 2008Rosowski et al 2003Rosowski et al , 2008 and analyzed using finite element (FE) models of the ear (Funnell et al 1987;Puria and Allen 1998;Koike et al 2002;Sun et al 2002;Gan et al 2004bWang et al 2007;Zhang and Gan 2011). However, single-point measurements cannot provide information about complex TM surface motion and the properties of sound wave propagation across the TM.…”

Section: Introductionmentioning

confidence: 99%

Experimental and Modeling Study of Human Tympanic Membrane Motion in the Presence of Middle Ear Liquid

Zhang

Guan

Nakmali

et al. 2014

JARO

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Vibration of the tympanic membrane (TM) has been measured at the umbo using laser Doppler vibrometry and analyzed with finite element (FE) models of the human ear. Recently, full-field TM surface motion has been reported using scanning laser Doppler vibrometry, holographic interferometry, and optical coherence tomography. Technologies for imaging human TM motion have the potential to lead to using a dedicated clinical diagnosis tool for identification of middle ear diseases. However, the effect of middle ear fluid (liquid) on TM surface motion is still not clear. In this study, a scanning laser Doppler vibrometer was used to measure the full-field surface motion of the TM from four human temporal bones. TM displacements were measured under normal and diseasemimicking conditions with different middle ear liquid levels over frequencies ranging from 0.2 to 8 kHz. An FE model of the human ear, including the ear canal, middle ear, and spiral cochlea was used to simulate the motion of the TM in normal and diseasemimicking conditions. The results from both experiments and FE model show that a simple deflection shape with one or two major displacement peak regions of the TM in normal ear was observed at low frequencies (1 kHz and below) while complicated ring-like pattern of the deflection shapes appeared at higher frequencies (4 kHz and above). The liquid in middle ear mainly affected TM deflection shapes at the frequencies higher than 1 kHz.

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“…These authors have shown that distortion product of the otoacoustic emissions (DPOAE) generated around 1 kHz respond to pressurerelated stapes impedance changes with change in phase relative to the generator tones, and provide a noninvasive means of assessing intralabyrinthine pressure changes [23]. They also demonstrated from their protocol the absence of any significant confounding middle-ear [24] effect to intracranial pressure ICP. They were described [25] as the relationship between intralabyrinthine and cerebrospinal fluid pressure from the otoacoustic emissions (OAEs) techniques.…”

Section: Introductionmentioning

confidence: 99%

The Estimation of the Time Constant of the Human Inner Ear Pressure Change by Noninvasive Technique

Traboulsi

Poumarat

Chazal

et al. 2009

Modelling and Simulation in Engineering

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We propose a noninvasive method to estimate the time constant. The calculation of this factor permits us to understand the pressure variations of the inner ear and also predict the behavior of the flow resistance of the cochlear aqueduct. A set of mathematical relationships incorporating the intralabyrinthine pressure, the intracranial pressure, and the time constant was applied. The modeling process describes the hydrodynamic effects of the cerebrospinal fluid in the intralabyrinthine fluid space, where the input and output of the created model are, respectively, the sinusoidal variation of the respiration signal and the distortion product of otoacoustic emissions. The obtained results were compared with those obtained by different invasive techniques. A long time constant was detected each time when the intracranial pressure increased; this phenomenon is related to the role of the cochlear aqueduct described elsewhere. The interpretation of this model has revealed the ability of these predictions to provide a greater precision for hydrodynamic variation of the inner ear, consequently the variation of the dynamic process of the cerebrospinal fluid.

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Combined effect of fluid and pressure on middle ear function

Cited by 23 publications

References 14 publications

Change of middle ear transfer function in otitis media with effusion model of guinea pigs

Change of middle ear transfer function in otitis media with effusion model of guinea pigs

Experimental and Modeling Study of Human Tympanic Membrane Motion in the Presence of Middle Ear Liquid

The Estimation of the Time Constant of the Human Inner Ear Pressure Change by Noninvasive Technique

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