Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability

Borim, Flávia Silva Arbex; Alexandre, Tiago da Silva; Néri, Anita Liberalesso; Máximo, Roberta de Oliveira; Silva, Marcela Fernandes; Oliveira, César de

doi:10.1016/j.jamda.2018.06.006

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…Vitamin D receptor (VDR) is expressed in different human tissues, which strengthens the hypothesis that VitD acts beyond its classical function of bone metabolism and calcium homeostasis, playing an important role in various systems [5]. In the central nervous system, for example, vitD seems to be associated…”

Section: Introductionsupporting

confidence: 54%

A Review of Clinical Trials about Vitamin D Supplementation's Effect on Physical Performance of Community Dwelling Oldest-Olds

Paixão¹,

Santos²,

Amarante³

et al. 2022

J Geriatr Med Gerontol

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Background: Although observational studies with community dwelling older adults demonstrate that low serum 25(OH)D (vitD) negatively impacts on the health, the effects of its supplementation are still controversial. The aim of this study is to review clinical trials that evaluated the effect of vitD supplementation on physical performance in community dwelling oldest old.Methods: A comprehensive search on electronic databases, including Pubmed, Medline, LILACS and Scielo was conducted. Eligible studies were clinical trials published between January 2015 and June 2021 in Portuguese, English and Spanish. The selected articles should meet the following inclusion criteria: Included elderlies aged 80 and over, independent, community-dwelling and of both sexes. Experimental studies with dependent elderly, institutionalized, hospitalized, diagnosed with dementia, acute and/or severe diseases were excluded.Results: Out of the 11533 articles from the literature search, 21 studies met the inclusion criteria. The results suggest that vitD supplementation alone in most studies does not improve physical performance, even in populations at higher risk (elderly people with insufficiency or deficiency of this vitamin, pre-frailty and frailty, functional impairment and advanced age). When combined with resistance exercise and with other nutrients that are also important for muscle health, there seems to be an improvement in physical tests. However, the heterogeneity of the studies carried out so far contribute to still contradictory results. Conclusion:Although vitD supplementation corresponds to a potential therapy to prevent physical decline in the elderly, studies with the Brazilian population will be needed to better clarify these effects in community dwelling oldest old.

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Section: Introductionsupporting

confidence: 54%

A Review of Clinical Trials about Vitamin D Supplementation's Effect on Physical Performance of Community Dwelling Oldest-Olds

Paixão¹,

Santos²,

Amarante³

et al. 2022

J Geriatr Med Gerontol

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“…The variations in prevalence depend on the cut-off value, age, geographic location, and ethnicity of the population under study. 30,31 The prevalence of dynapenia in our study population was observed to be 31.3%, so it is within the middle range. In the present study, age and adiposity were significantly associated with a higher risk of dynapenia and interestingly, we found that women with a higher femoral neck T-score were less likely to have dynapenia.…”

Section: Dynapenia In Postmenopausal Womenmentioning

confidence: 57%

Handgrip strength, dynapenia, and related factors in postmenopausal women

et al. 2021

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Objective: This study aimed to evaluate the prevalence of dynapenia and factors related to low dominant handgrip strength (HGS) in postmenopausal women.Methods: A cross-sectional study was performed on 249 postmenopausal women aged 50 to 84 years. The following variables were recorded: age, age at menopause, smoking status, and the HGS measured with a digital dynamometer, body mass index, and adiposity assessed by bioelectric impedance. The physical activity level was evaluated by using the International Physical Activity Questionnaire. Bone mineral density was reported as T-scores, and blood biochemical parameters (calcium, phosphorus, vitamin D, and parathormone levels) were measured.Results: 31.3% of women had dynapenia, and those aged !65 years had lower HGS (P < 0.001). Age at menopause was also associated with HGS, with those with menopause < 51 showing lower HGS (P ¼ 0.005). Likewise, fat content ! 40%, and osteopenia/osteoporosis were also related to lower strength (P < 0.001). There was no statistically significant difference among HGS with respect to body mass index, smoking status, and plasma levels of vitamin D. A logistic regression model with lower Akaine Information Criterion showed that for every year in age and for each 1% of adiposity, women were more likely to have dynapenia with odd ratio (OR): 1.09; 95% and confidence interval (CI): 1.04 to 1.14 and OR: 1.06; 95% CI: 1.00 to 1.13, respectively. Conversely, women with higher femoral neck T-score were less likely to have dynapenia (OR: 0.53; 95% CI: 0.35-0.78).Conclusions: HGS was associated with age at menopause, bone mineral density, and adiposity adjusted by age. The age and adiposity were significantly associated with a higher risk of dynapenia, whereas women with higher femoral neck T-score were less likely to have dynapenia.

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“…The season of the year in which blood was collected for the determination of serum 25(OH)D was recorded and used as a control variable: spring (March–May), summer (June–August), autumn (September–November), and winter (December–February) ( 38 ). Vitamin D supplementation and the use of carbamazepine [an anticonvulsant medication with the potential to reduce serum 25(OH)D concentrations] were also used as control variables ( 39 ).…”

Section: Methodsmentioning

confidence: 99%

Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age

Luiz

Máximo

Oliveira

et al. 2020

The Journal of Nutrition

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Background Vitamin D deficiency compromises muscle function and is related to the etiology of several clinical conditions that can contribute to the development of disability. However, there are few epidemiological studies investigating the association between vitamin D deficiency and the incidence of disability. Objectives We aimed to assess whether vitamin D deficiency is associated with the incidence of disability in basic activities of daily living (BADL) and to verify whether there are sex differences in this association. Methods A 4-y follow-up study was conducted involving individuals aged 50 y or older who participated in ELSA (English Longitudinal Study of Ageing). The sample consisted of 4814 participants free of disability at baseline according to the modified Katz Index. Vitamin D was assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations and the participants were classified as sufficient (>50 nmol/L), insufficient (>30 to ≤50 nmol/L), or deficient (≤30 nmol/L). Sociodemographic, behavioral, and clinical characteristics were also investigated. BADL were re-evaluated after 2 and 4 y of follow-up. The report of any difficulty to perform ≥1 BADL was considered as an incident case of disability. Poisson models stratified by sex and controlled for sociodemographic, behavioral, and clinical characteristics were carried out. Results After 4-y follow-up, deficient serum 25(OH)D was a risk factor for the incidence of BADL disability in both women (IRR: 1.53; 95% CI: 1.16, 2.03) and men (IRR: 1.44; 95% CI: 1.02, 2.02). However, insufficient serum 25(OH)D was not a risk factor for the incidence of BADL disability in either men or women. Conclusions Independently of sex, deficient serum 25(OH)D concentrations were associated with increased risk of incidence of BADL disability in adults >50 y old and should be an additional target of clinical strategies to prevent disability in these populations.

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Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability

Abstract: Dynapenia only and dynapenia combined with low 25 (OH) D serum levels were important risk factors for ADL disability in middle-aged individuals and older adults in 2 years of follow-up.

Cited by 12 publications

References 33 publications

A Review of Clinical Trials about Vitamin D Supplementation's Effect on Physical Performance of Community Dwelling Oldest-Olds

A Review of Clinical Trials about Vitamin D Supplementation's Effect on Physical Performance of Community Dwelling Oldest-Olds

Handgrip strength, dynapenia, and related factors in postmenopausal women

Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age

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