Combined Effect of Atovaquone and Pyrrolidine Dithiocarbamate in the Treatment of Acute Murine Toxoplasmosis

Djurković–Djaković, Olgica; Nikolić, Aleksandra; Bobić, Branko; Klun, Ivana

doi:10.1159/000077891

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The 95% confidence intervals were used to determine significant differences between ED 50 of antifungals. The survival time between the control group, L-AMB treatment groups and VRC treatment group was compared using the log-rank test [21,22] . Student's t test and Dunnett's test for multiple comparisons were used to assess significant differences in the fungal burden.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on the Efficacy of Liposomal Amphotericin B and Voriconazole in a Murine Pulmonary Aspergillosis Model

Koji

Yamamoto²,

Ueda³

et al. 2009

Chemotherapy

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Background:No clinical studies have compared the efficacy of liposomal formulation AMB (L-AMB) and voriconazole (VRC) in the treatment of pulmonary aspergillosis. The aim of this study was to compare the efficacy of L-AMB and VRC in murine pulmonary aspergillosis.Methods: Leucopenic mice were infected intratracheally with Aspergillus fumigatus and treated intravenously with L-AMB (once a day) or VRC (twice a day). Results: L-AMB and VRC at a dose of ≥5 and ≥20 mg/kg, respectively, significantly prolonged the survival time of infected mice and reduced the pulmonary fungal burden in comparison with the control group. At the maximum recommended dose for clinical use, 5 mg/kg of L-AMB exhibited greater efficacy than 10 mg/kg of VRC, which achieved an area under the concentration-time curve level equivalent to that of 6 mg/kg (loading dose) in humans, in terms of increasing survival and reducing the fungal burden. Conclusion: The in vivo efficacy of L-AMB was superior to that of VRC at the maximum recommended dose in a murine pulmonary aspergillosis model.

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Section: Discussionmentioning

confidence: 99%

Comparative Study on the Efficacy of Liposomal Amphotericin B and Voriconazole in a Murine Pulmonary Aspergillosis Model

Koji

Yamamoto²,

Ueda³

et al. 2009

Chemotherapy

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show abstract

“…Também são aplicados com potentes inibidores da protease do HIV-1 [17][18][19] assim como agentes coadjuvantes no tratamento de infecções oportunistas em pacientes com síndrome da imunodeficiência adquirida [20]. Além de serem ótimos indutores de apoptose em diversos tipos de células cancerígenas [21][22], como câncer renal e de mama [23][24].…”

Section: Os Ditiocarbamatosunclassified

Estudo estrutural e estereoquímico de derivados de ditiocarbamatos: supramolecularidade

Landgraff¹

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Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate

Djurković–Djaković¹,

Nikolić²,

Bobić³

et al. 2005

Microbes and Infection

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Combined Effect of Atovaquone and Pyrrolidine Dithiocarbamate in the Treatment of Acute Murine Toxoplasmosis

Cited by 4 publications

References 16 publications

Comparative Study on the Efficacy of Liposomal Amphotericin B and Voriconazole in a Murine Pulmonary Aspergillosis Model

Comparative Study on the Efficacy of Liposomal Amphotericin B and Voriconazole in a Murine Pulmonary Aspergillosis Model

Estudo estrutural e estereoquímico de derivados de ditiocarbamatos: supramolecularidade

Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate

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