Combined Dietary Anthocyanins, Flavonols, and Stilbenoids Alleviate Inflammatory Bowel Disease Symptoms in Mice

Scarano, Aurelia; Butelli, Eugenio; Santis, Stefania De; Cavalcanti, Elisabetta; Hill, Lionel; Angelis, Maria De; Giovinazzo, Giovanna; Chieppa, Marcello; Martin, Cathie; Santino, Angelo

doi:10.3389/fnut.2017.00075

Cited by 92 publications

(120 citation statements)

References 38 publications

(43 reference statements)

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“…All these compounds have been associated to the health-promoting properties of fruits and vegetables [19,22]. Our results are in agreement with other studies, which reported a higher content of these phytochemicals in the cortex of different purple carrot varieties [5].…”

Section: Discussionsupporting

confidence: 93%

“…On these bases, their consumption might have positive effects on human health. Other studies indicate that diets rich in anthocyanins and phenolic acids have protective effects against oxidative stress, involved in the onset of aging processes and several human pathologies [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…The supernatants were combined and dried with a rotary evaporator. Samples were resuspended in 1 ml of ethyl acetate and analyzed by RP-HPLC DAD as previously described [22].…”

Section: Carotenoid Contentmentioning

confidence: 99%

“…In plants, anthocyanins are synthetized by the flavonoid biosynthetic pathway, which leads also to the production of phenolic acids and other classes of polyphenols with healthy benefits [20][21][22]. In this study, we carried out the chemical profiling of antioxidant compounds and characterized the main classes of polyphenols, carotenoids, sugars, and organic acids, which can contribute to the quality and nutritional value of Tiggiano carrots and to the valorization of this local landrace.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Analysis and Antioxidant Properties in Colored Tiggiano Carrots

et al. 2018

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Abstract:The carrot (Daucus carota L.) is an important vegetable source of bioactive compounds in the human diet. In the Apulia region (Southern Italy), local farmers have domesticated colored landraces of carrots over the years, strictly related to local cults and traditions. Amongst these, an important landrace is the carrot of Saint Ippazio or the Tiggiano carrot. In the present study, we evaluated the content of carotenoids, anthocyanins, phenolic acids, sugars, organic acids, and antioxidant activity in Tiggiano carrots. Our results indicated that yellow-purple carrots have the highest levels of bioactive compounds, together with the highest antioxidant capacity compared to the yellow and cultivated orange varieties. These data point out the nutritional value of purple Tiggiano carrots and may contribute to the valorization of this typical landrace.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…The supernatants were combined and dried with a rotary evaporator. Samples were resuspended in 1 ml of ethyl acetate and analyzed by RP-HPLC DAD as previously described [22].…”

Section: Carotenoid Contentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical Analysis and Antioxidant Properties in Colored Tiggiano Carrots

et al. 2018

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“…Extracts were centrifuged, evaporated using a rotary evaporator, and collected in 1 mL of ethyl acetate. Analyses were performed using RP‐HPLC DAD (Agilent 1100 HPLC system) according to the method previously described …”

Section: Methodsmentioning

confidence: 99%

Selection of tomato landraces with high fruit yield and nutritional quality under elevated temperatures

et al. 2020

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BACKGROUND Global warming and extreme or adverse events induced by climatic fluctuations are an important threat for plants growth and agricultural production. Adaptability to environmental changes prevalently derives from a large set of genetic traits affecting physiological and agronomic parameters. Therefore, the identification of genotypes that are good yield performer at high temperatures is becoming increasingly necessary for future breeding programs. Here, we analyzed the performances of different tomato landraces grown under elevated temperatures in terms of yield and nutritional quality of the fruit. Finally, we evaluated the antioxidant and anti‐inflammatory activities of fruit extracts from the tomato landraces selected. RESULTS The tomato landraces analyzed here in a hot climate differed in terms of yield performance, physicochemical parameters of fruit (pH, titratable acidity, degrees Brix, firmness), bioactive compounds (ascorbic acid, carotenoids, and polyphenols), and anti‐inflammatory potential. Three of these landraces (named E30, E94, and PDVIT) showed higher fruit quality and nutritional value. An estimated evaluation index allowed identification of PDVIT as the best performer in terms of yield and fruit quality under high temperatures. CONCLUSION The analyses performed here highlight the possibility to identify new landraces that can combine good yield performances and fruit nutritional quality at high temperatures, information that is useful for future breeding programs. © 2020 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases

Liu,

He,

Fang

et al. 2023

Advanced NanoBiomed Research

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Intestinal diseases like inflammatory bowel disease (IBD) and colorectal cancer originate from inflammation and disruption of mucosal barriers. Polyphenols can mitigate intestinal inflammation through antioxidant, anti‐inflammatory, and microbiome modulation effects. However, the poor solubility and stability of polyphenols restrict therapeutic delivery. Self‐assembly provides a nanoscale platform to overcome these limitations. Polyphenol‐based nanoparticles (PNPs) are formed via coordination of polyphenols with metals like iron, copper, and zinc based on the catechol/galloyl groups. Templeted assembly with amphiphilic block copolymers can also direct polyphenol self‐assembly into nanostructures. PNPs prepared by these mild, aqueous methods exhibit enhanced stability, pH‐responsive disassembly, high cargo‐loading capacity, and targeted accumulation in inflamed intestinal tissues. PNPs can load with hydrophobic polyphenols, drugs, genes, proteins, or probiotics and demonstrate therapeutic potential in preclinical IBD, colorectal cancer, and microbiome disorder models. Ongoing challenges include augmenting prebiotic effects, multidrug encapsulation, and engineering PNPs as biotherapeutics. Future directions involve tailored polyphenol–polymer covalent assemblies and investigating PNPs interactions with enterocytes, immune cells, and microbiota. Overall, PNPs prepared by facile self‐assembly combine the bioactivities of polyphenols with advanced delivery functionality, presenting new opportunities for combination and microbiota‐based therapies for complex intestinal diseases.

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Combined Dietary Anthocyanins, Flavonols, and Stilbenoids Alleviate Inflammatory Bowel Disease Symptoms in Mice

Cited by 92 publications

References 38 publications

Phytochemical Analysis and Antioxidant Properties in Colored Tiggiano Carrots

Phytochemical Analysis and Antioxidant Properties in Colored Tiggiano Carrots

Selection of tomato landraces with high fruit yield and nutritional quality under elevated temperatures

Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases

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