Combined delivery of curcumin and the heme oxygenase-1 gene using cholesterol-conjugated polyamidoamine for anti-inflammatory therapy in acute lung injury

Kim, Gyeungyun; Piao, Chunxian; Oh, Jungju; Lee, Minhyung

doi:10.1016/j.phymed.2018.09.240

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…Treatment with curcumin remarkably improved the histopathological parameters in BaP-induced lung injury and lung tissue damage was statically less or mild. The results were in agreement with previous reports that showed curcumin, and its analogs have a protective effect on pulmonary injury in different acute as well as chronic lung injury models [22,28,29]. Lipid peroxidation is one of the leading mechanisms of reactive oxygen species-induced cell damage.…”

Section: Discussionsupporting

confidence: 93%

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats

et al. 2020

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Benzo(a)pyrene (BaP) is a well-known carcinogen and enhances oxidative stress and apoptosis and also alters several molecular pathways. Curcumin is an active ingredient of Curcuma longa, and it has potent anti-inflammatory, antioxidant activity that defends cells from oxidative stress and cell death. The objectives of the present study were to explore the protective effects of curcumin against long-term administration of BaP induced disturbances in lungs of rats. Male rats were randomly divided into four groups: saline control, BaP only, BaP + curcumin, and curcumin only. Lung histopathology, electron microscopy, inflammatory cytokine release, antioxidant levels, apoptosis, and cell cycle were examined. Instillation of BaP significantly increased infiltration of inflammatory cells in alveolar space and inflammatory cytokine in blood. BaP induced lung tissue alterations including mild bronchitis, scant chronic inflammatory cell infiltrate in the wall of the respiratory bronchiole, and mild intra-alveolar haemorrhage. However, these alterations were found to be significantly less as mild inflammatory cell infiltrate in curcumin plus BaP treated group. Furthermore, electron microscopy results also showed necrotic changes and broken cell membrane of Type-II epithelial cell of alveoli in BaP group, which was reduced after adding curcumin treatment. In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum. Moreover, the levels of tunnel staining and p53 expression were significantly increased by BaP, whereas these changes were noticeably modulated after curcumin treatment. BaP also interferes in normal cell cycle, which was significantly improved with curcumin treatment. Overall, our findings suggest that curcumin attenuates BaP -induced lung injury, probably through inhibiting inflammation, oxidative stress and apoptosis in lung epithelial cells, and improving cell proliferation and antioxidants level. Thus, curcumin may be an alternative therapy for improving the outcomes of Benzo(a)pyrene-induced lung injury.

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Section: Discussionsupporting

confidence: 93%

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats

et al. 2020

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“…CALMI gene plays an important role in the intracellular Calcium signaling pathway [43]. As a marker of adipose tissue dysfunction induced by iron excess, HMOX1 gene can affect the glucose uptake and respiratory ability of human adipocytes [44]. The JUN gene plays an important role in immune anti-inflammation [45,46].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension

Liu

Chen

et al. 2020

Med Sci Monit

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“…Synthetic polymers are usually coated with polyethylene glycol (PEG) to reduce their toxicity and increase their solubility. Their high drug-loading capacity makes them favorable carriers for in vivo therapies; 102 they deliver drugs 19,23,[28][29][30]34,[70][71][72] and genes 31,33,53,[62][63][64][65][68][69][70][71][72][73] to the targeted site or act as therapeutic agents by themselves 52,67 for ALI treatment (Table 3).…”

Section: Polymeric Nanomedicinementioning

confidence: 99%

“…2 To target the endothelium and epithelium, intercellular adhesion molecule-1 (ICAM-1), 87 plateletendothelial cell adhesion molecule (PECAM-1) 88 and surfactant protein (SP) 89 can be bio-conjugated by corresponding antibodies for active targeting nanotherapy. [20][21][22]24,28,35,56,60,63 Nanomedicine can restore barrier integrity and prevent cell death by influencing inflammatory pathways 20,21,44,60,63,65,[70][71][72] and alleviating oxidative stress. 28,35,36,42,54,56 The influence of nanomedicine on cellular architecture can be assessed by a pragmatic optimized air-liquid interface system, which showed comparable results as those in an in vivo study.…”

mentioning

confidence: 99%

“…69 Cholesterol-conjugated polyamidoamine micelles could deliver pHO-1 (heme-oxygenase -1 plasmid) along with RSV or Cur, in which pHO-1 induced HO-1 expression to decrease pro-inflammatory cytokines, and RSV or Cur inhibited the inflammatory reactions synergically. 70,71 The phosphorus dendrimers have been shown to have more efficiency in the cellular delivery of siRNA 108 and exhibited anti-inflammatory properties simultaneously. 109 Compared with morpholinium-containing dendriplexes, pyrrolidinium-decorating dendriplexes demonstrated a stronger siRNA complexation, and the higher cellular uptake enabled an enhanced silencing efficiency of TNF-α 73 (Figure 3G).…”

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confidence: 99%

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Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Bian¹,

Cai²,

Cui³

et al. 2021

IJN

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Acute lung injury (ALI) or its aggravated stage acute respiratory distress syndrome (ARDS) may lead to a life-threatening form of respiratory failure, resulting in high mortality of up to 30-40% in most studies. Although there have been decades of research since ALI was first described in 1967, the clinical therapeutic alternatives for ALI are still in a state of limited availability. Supportive treatment and mechanical ventilation still have priority. Despite some preclinical studies demonstrating the benefit of pharmacological interventions, none of these has been proved completely effective to date. Recent advances in nanotechnology may shed new light on the pharmacotherapy of ALI. Nanomedicine possesses targeting and synergistic therapeutic capability, thus boosting pharmaceutical efficacy and mitigating the side effects. Currently, a variety of nanomedicine with diverse frameworks and functional groups have been elaborately developed, in accordance with their lung targeting ability and the pathophysiology of ALI. The in-depth review of the current literature reveals that liposomes, polymers, inorganic materials, cell membranes, platelets, and other nanomedicine approaches have conferred attractive therapeutic benefits for ALI treatment. In this review, we explore the recent progress in the study of the nanomedicinebased therapy of ALI, presenting various nanomedical approaches, drug choices, therapeutic strategies, and outcomes, thereby providing insight into the trends.

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Combined delivery of curcumin and the heme oxygenase-1 gene using cholesterol-conjugated polyamidoamine for anti-inflammatory therapy in acute lung injury

Cited by 22 publications

References 29 publications

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats

Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

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