Abstract:By regulating recognition, signaling and physiology of neurons, gangliosides are essential to CNS function. The composition of gangliosides in the brain changes during development and aging being regulated by neuraminidases presumably, which cleave their terminal sialic acid residues. Two mammalian neuraminidases, Neu3 and Neu4 are major candidates for processing brain gangliosides, however, the corresponding knockout mice showed no changes in brain ganglioside metabolism or deficits in brain function.To eluci… Show more
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