Combined damage produced by multiple mild cerebral insults assessed using MRI in neonatal rats

Tuor, Ursula I.; Sule, Manasi; Qiao, Min

doi:10.1016/j.neulet.2016.09.057

Cited by 1 publication

(1 citation statement)

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“…Such enhancement extended to an adjacent lesion region in an adjacent MR slice when there was an acute but not chronic recovery time between insults. Heterogeneous increases in T 2 within the vicinity of a PT, generally consistent with those of the present study, have also been observed in neonatal rats subjected to a minor PT followed 2 days later by unilateral cerebral hypoxia–ischemia [16]. …”

Section: Discussionsupporting

confidence: 90%

Magnetic resonance imaging detection of multiple ischemic injury produced in an adult rat model of minor stroke followed by mild transient cerebral ischemia

Tuor

Qiao

2016

Magn Reson Mater Phy

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ObjectivesTo determine whether cumulative brain damage produced adjacent to a minor stroke that is followed by a mild transient ischemia is detectable with MRI and histology, and whether acute or chronic recovery between insults influences this damage.Materials and methodsA minor photothrombotic (PT) stroke was followed acutely (1–2 days) or chronically (7 days) by a mild transient middle cerebral artery occlusion (tMCAO). MRI was performed after each insult, followed by final histology.ResultsThe initial PT produced small hyperintense T2 and DW infarct lesions and peri-lesion regions of scattered necrosis and modestly increased T2. Following tMCAO, in a slice and a region adjacent to the PT, a region of T2 augmentation was observed when recovery between insults was acute but not chronic. Within the PT slice, a modest region of exacerbated T2 change proximate to the PT was also observed in the chronic group. Corresponding histological changes within regions of augmented T2 included increased vacuolation and cell death.ConclusionWithin regions adjacent to an experimental minor stroke, a recurrence of a mild transient cerebral ischemia augmented T2 above increases produced by tMCAO alone, reflecting increased damage in this region. Exacerbation appeared broader with acute versus chronic recovery between insults.Electronic supplementary materialThe online version of this article (doi:10.1007/s10334-016-0597-5) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%