Combined cystic teratoma and hepatoblastoma of the liver: Probable divergent differentiation of an uncommitted hepatic precursor cell

Abstract

Background. Hepatic cystic teratoma is an extremely rare tumor and hepatoblastoma a relatively rare tumor of childhood. Their occurrence as a combined tumor has not been previously reported. Methods. The relevant clinical, radiologic, and pathologic findings are presented. Results. A 17‐month‐old boy presented with an abdominal mass. Imaging studies suggested an intrahepatic teratoma, but serum alpha‐fetoprotein levels were extremely elevated. The resected tumor comprised adjoining benign cystic teratoma and epithelial hepatoblastoma. The child remains alive and well 37 months after complete resection of the tumor. Conclusions. The tumor was considered most likely to originate from divergent differentiation of a single uncommitted liver precursor cell.

Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challenge

“…In summary, we report on the diagnosis and clinical management of to our knowledge the second case of a mixed hepatoblastoma and teratoma in a young boy [10]. Clearly, this represents a rare facet of embryonic tumors within the liver.…”

Natural history and long-term follow-up of antenatally detected liver cysts

“…The differential diagnosis of non-bile-containing intrahepatic cysts as described in this article includes mesenchymal hamartoma [7][8][9] and, rarely, embryonal sarcoma [10,11] as well as cystic teratoma [12]. Other developmental liver diseases characterized by a more multicystic appearance (eg, Caroli's disease [13] and polycystic disease of the liver) have also been detected antenatally and shown to regress [14].…”

Huge immature teratoma of the liver in an adult: a case report and review of the literature

“…Most of the reported cases were intraperitoneal or retroperitoneal teratomas with secondary invasion to the liver, so true hepatic teratomas are extremely rare [5][6][7][8]. Out of 25 cases, 10 were liver teratoma in adults [1,[3][4][5][6][9][10][11].…”