Combined continuous flow isotope ratio mass spectrometry techniques for tracing the metabolism of 13C-labelled fatty acids

Brookes, S. T.; Craig, Kerr S.; Cunnane, Stephen C.

doi:10.1042/bst022164s

Cited by 4 publications

(1 citation statement)

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“…Brossard et al studied the incorporation of polyunsaturated fatty acids into rat lipoproteins and red cells after ingestion of 13 C‐labelled triglycerides 72. Similarly, the incorporation of fatty acids in rat brain has been described by Brookes et al 73 Since fatty acids are usually analysed as their methyl ester derivatives, methods to take into account the isotopic value of the added methyl group have been described 74,. 75 In order to measure triacylglycerol synthesis rate in humans, Scrimgeour et al used GC‐Py‐IRMS to measure the incorporation of D 2 O into plasma fatty acids 76…”

Section: Biomedicalmentioning

confidence: 93%

Compound-specific isotope analysis. Application to archaelogy, biomedical sciences, biosynthesis, environment, extraterrestrial chemistry, food science, forensic science, humic substances, microbiology, organic geochemistry, soil science and sport

Lichtfouse

2000

Rapid Commun. Mass Spectrom.

122

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The isotopic composition, for example, 14C/12C, 13C/12C, 2H/1H, 15N/14N and 18O/16O, of the elements of matter is heterogeneous. It is ruled by physical, chemical and biological mechanisms. Isotopes can be employed to follow the fate of mineral and organic compounds during biogeochemical transformations. The determination of the isotopic composition of organic substances occurring at trace level in very complex mixtures such as sediments, soils and blood, has been made possible during the last 20 years due to the rapid development of molecular level isotopic techniques. After a brief glance at pioneering studies revealing isotopic breakthroughs at the molecular and intramolecular levels, this paper reviews selected applications of compound‐specific isotope analysis in various scientific fields. Copyright © 2000 John Wiley & Sons, Ltd.

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